Review of time in therapeutic range of warfarin in a tertiary centre in Malaysia

Anticoagulation management is a recognized challenge in medical care. Complications of supratherapeutic anticoagulation are hemorrhagic stroke, major bleeding, and death. There is an even greater risk of ischemic stroke in AF, worsening of VTE associated with subtherapeutic dosing

The design of computationally efficient narrowband and wideband sharp FIR filters

10.1109/ISCAS.2009.5117740Proceedings - IEEE International Symposium on Circuits and Systems281-284PICS

Addressing opposition quality in basketball performance evaluation

The aim of this research was twofold: (i) to explain the relationships between basketball indicators and opposition quality; and (ii) to utilise regression models in the evaluation of basketball team performances that account for opposition quality. Opposition quality was represented in absolute terms without considering a team’s own quality (OQ) and relative terms as the difference between the quality of a team and their opponents (RQ). Game-related indicators of all the 92 games of the Basketball World Cup 2019 were analysed. Regression analysis was used to model performance indicators in terms of OQ and RQ. Correlations between opposition quality and basketball indicators were statistically low in both terms. However, higher correlations were found between assists, two-point field goal accuracy, defensive rebounds and RQ. Two-point field goal attempts (2 PA) exhibited a negative relationship considering opposition quality. Most of the variables showed higher correlations with RQ than OQ. Offensive rebounds and personal fouls were influenced more by OQ than by RQ. Subsequently, teams over-performing or under-performing when addressing opposition quality could be recognised. This allowed trends in performance and consistency of performance to be evaluated. Evaluation scores were more consistent in absolute terms rather than relative terms

A new, efficient, and inexpensive copper(II)/salicylic acid complex catalyzed Sonogashira-type cross-coupling of haloarenes and iodoheteroarenes with terminal alkynes

A new, efficient, and inexpensive CuCl(2)/salicylic acid catalytic system has been developed to catalyze Sonogashira-type cross-coupling of haloarenes and iodoheteroarenes with terminal alkynes under mild reaction conditions to afford the corresponding coupling products in 18-95% yields. The role of salicylic acid might act as a bidentate O,O-donor ligand to activate the catalytic reactivity of copper chloride in coupling reactions was also briefly discussed. (C) 2010 Elsevier Ltd. All rights reserved

3D local structure around copper site of rabbit prion-related protein: Quantitative determination by XANES spectroscopy combined with multiple-scattering calculations

Prion-related protein (PrP), a cell-surface copper-binding glycoprotein, is considered to be responsible for a number of transmissible spongiform encephalopathies (TSEs). The structural conversion of PrP from the normal cellular isoform (PrPC) to the post-translationally modified form (PrPSc) is thought to be relevant to Cu2+ binding to histidine residues. Rabbits are one of the few mammalian species that appear to be resistant to TSEs, because of the structural characteristics of the rabbit prion protein (RaPrPC) itself. Here we determined the three-dimensional local structure around the C-terminal high-affinity copper-binding sites using X-ray absorption near-edge structure combined with ab initio calculations in the framework of the multiple-scattering (MS) theory. Result shows that two amino acid resides, Gln97 and Met108, and two histidine residues, His95 and His110, are involved in binding this copper(II) ion. It might help us understand the roles of copper in prion conformation conversions, and the molecular mechanisms of prion-involved diseases. ? 2013 Elsevier Ltd