Association of acute disseminated encephalomyelitis (ADEM) and COVID-19 in a pediatric patient

Cases of acute disseminated encephalomyelitis (ADEM) and its hyperacute form, acute hemorrhagic leukoencephalitis (AHLE), have been reported in coronavirus disease 2019 (COVID-19) patients as rare, but most severe neurological complications. However, histopathologic evaluations of ADEM/AHLE pathology in COVID patients are extremely limited, so far having only been reported in a few adult autopsy cases. Here we compare the findings with an ADEM-like pathology in a pediatric patient taken through a biopsy procedure. Understanding the neuropathology may shed informative light on the autoimmune process affecting COVID-19 patients and provide critical information to guide the clinical management

Oil Prices, Profits, and Recessions : An Inquiry Using Terrorism as an Instrumental Variable

Nearly all post-war recessions have been preceded by oil-price shocks, but is this because spikes in the price of petroleum cause economic downturns? Most research has ignored an identification problem : oil prices and the state of the world economy are endogenously determined. This paper uses terrorist incidents as an instrumental variable. In an international panel of industries, we show that after correction for simultaneity bias — though not before — the price of oil has large negative effects upon profitability. Our results seem to lend support to the claim that oil-price spikes can be a source of recessions.

The AdS3_3 Propagator and the Fate of Locality

We recently used Virasoro symmetry considerations to propose an exact formula for a bulk proto-field $\phi$ in AdS$_3$. In this paper we study the propagator $\langle \phi \phi \rangle$. We show that many techniques from the study of conformal blocks can be generalized to compute it, including the semiclassical monodromy method and both forms of the Zamolodchikov recursion relations. When the results from recursion are expanded at large central charge, they match gravitational perturbation theory for a free scalar field coupled to gravity in our chosen gauge. We find that although the propagator is finite and well-defined at long distances, its perturbative expansion in $G_N = \frac{3}{2c}$ exhibits UV/IR mixing effects. If we nevertheless interpret $\langle \phi \phi \rangle$ as a probe of bulk locality, then when $G_N m_\phi \ll 1$ locality breaks down at the new short-distance scale $\sigma_* \sim \sqrt[4]{G_N R_{AdS}^3}$. For $\phi$ with very large bulk mass, or at small central charge, bulk locality fails at the AdS length scale. In all cases, locality `breakdown' manifests as singularities or branch cuts at spacelike separation arising from non-perturbative quantum gravitational effects.Comment: 42+17 pages, 7 figure

The Bulk-to-Boundary Propagator in Black Hole Microstate Backgrounds

First-quantized propagation in quantum gravitational AdS$_3$ backgrounds can be exactly reconstructed using CFT$_2$ data and Virasoro symmetry. We develop methods to compute the bulk-to-boundary propagator in a black hole microstate, $\langle \phi_L \mathcal{O}_L \mathcal{O}_H \mathcal{O}_H\rangle$, at finite central charge. As a first application, we show that the semiclassical theory on the Euclidean BTZ solution sharply disagrees with the exact description, as expected based on the resolution of forbidden thermal singularities, though this effect may appear exponentially small for physical observers.Comment: 34+27 pages, 7 figures; v2: typos correcte

Degenerate Operators and the 1/c1/c Expansion: Lorentzian Resummations, High Order Computations, and Super-Virasoro Blocks

One can obtain exact information about Virasoro conformal blocks by analytically continuing the correlators of degenerate operators. We argued in recent work that this technique can be used to explicitly resolve information loss problems in AdS$_3$/CFT$_2$. In this paper we use the technique to perform calculations in the small $1/c \propto G_N$ expansion: (1) we prove the all-orders resummation of logarithmic factors $\propto \frac{1}{c} \log z$ in the Lorentzian regime, demonstrating that $1/c$ corrections directly shift Lyapunov exponents associated with chaos, as claimed in prior work, (2) we perform another all-orders resummation in the limit of large $c$ with fixed $cz$, interpolating between the early onset of chaos and late time behavior, (3) we explicitly compute the Virasoro vacuum block to order $1/c^2$ and $1/c^3$, corresponding to $2$ and $3$ loop calculations in AdS$_3$, and (4) we derive the heavy-light vacuum blocks in theories with $\mathcal{N}=1,2$ superconformal symmetry.Comment: 34+20 pages, 2 figure