Trois initiatives en matière d’adaptation au changement climatique

L’article met l’accent sur trois initiatives qui se sont intéressées à la problématique du changement climatique et à l’adaptation à ses effets, au travers de l’expérimentation de terrain, de la formation des administrations et de la production de données. Le projet For Climadapt (programme MED) a développé des méthodes et des outils à destination des acteurs de terrain, au travers de visites de terrain, d’échanges d’informations et de partage d’expérience. Le projet régional GIZ a concouru à la montée en compétence des administrations, forestières et non forestières, de cinq pays méditerranéens, au travers de deux approches d’adaptation au changement climatique : une sectorielle, sur l’adaptation des forêts, et une multisectorielle, sur le rôle des forêts dans l’adaptation des territoires et des populations (adaptation fondée sur les écosystèmes forestiers). La composante 1 du projet financé par le FFEM a permis la production d’une grande quantité de données, notamment cartographiques : cartes de vulnérabilité, cartes d’évolution du couvert, simulation des conditions climatiques, base de données de la littérature sur le sujet

Three initiatives in terms of adaptation to climate change

The article focuses on three initiatives that have addressed the issue of climate change and adaptation to its effects, through field experimentation, administrations training and data production. The For Climadapt project (MED programme) has developed methods and tools for actors in the field, through field visits, exchange of information and sharing of experience. The GIZ regional project has contributed to the capacity building of forest and non-forest administrations, in five Mediterranean countries, through two approaches to adaptation to climate change: a sectorial, on the adaptation of forests, and a multisectorial on the role of forests in the adaptation of territories and populations (Forest Ecosystem-based adaptation, FEbA). The component 1 of the project financed by the FFEM has enabled the production of large amounts of data, in particular maps: vulnerability maps, evolution of forest cover and land use maps, future projections of climate conditions, database of the literature on the subject

AGFORWARD: achievments during the first two years

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AGFORWARD Third Periodic Report: July 2016 to December 2017

Project context The European Union has targets to improve the competitiveness of European agriculture and forestry, whilst improving the environment and the quality of rural life. At the same time there is a need to improve our resilience to climate change and to enhance biodiversity. During the twentieth century, large productivity advances were made by managing agriculture and forestry as separate practices, but often at a high environmental cost. In order to address landscape-scale issues such as biodiversity and water quality, we argue that farmers and society will benefit from considering landuse as a continuum including both agriculture and trees, and that there are significant opportunities for European farmers and society to benefit from a closer integration of trees with agriculture. Agroforestry is the practice of deliberately integrating woody vegetation (trees or shrubs) with crop and/or animal systems to benefit from the resulting ecological and economic interactions.AGFORWARD (Grant Agreement N° 613520) is co-funded by the European Commission, Directorate General for Research & Innovation, within the 7th Framework Programme of RTD. The views and opinions expressed in this report are purely those of the writers and may not in any circumstances be regarded as stating an official position of the European Commissio

AGFORWARD Project Final Report

Executive summary: The AGFORWARD project (Grant Agreement N° 613520) had the overall goal to promote agroforestry practices in Europe that will advance sustainable rural development. It had four objectives (described below) which address 1) the context and extent of agroforestry in Europe, 2) identifying, developing and field-testing agroforestry innovations through participatory networks, 3) evaluating innovative designs and practices at field-, farm-, and landscape-scales, and promoting agroforestry in Europe through policy development and dissemination. Agroforestry is defined as the practice of deliberately integrating woody vegetation (trees or shrubs) with crop and/or animal systems to benefit from the resulting ecological and economic interactions. Context: European agroforestry has been estimated to cover 10.6 Mha (using a literature review) and 15.4 Mha using the pan-European LUCAS dataset (i.e. 8.8% of the utilised agricultural area). Livestock agroforestry (15.1 Mha) is, by far, the dominant type of agroforestry. The LUCAS analysis provides a uniform method to compare agroforestry areas between countries and over time. Identify, develop and field-test agroforestry innovations: 40 stakeholder groups (involving about 820 stakeholders across 13 European countries) developed and field-tested agroforestry innovations which have been reported in 40 “lesson learnt” reports, and in a user-friendly format in 46 “Agroforestry innovation leaflets”. The innovations for agroforestry systems of high nature and cultural value included cheaper methods of tree protection and guidance for establishing legumes in wood pastures. Innovations for agroforestry with timber plantations, olive groves and apple orchards include the use of medicinal plants and reduction of mowing costs. Innovations for integrating trees on arable farms included assessments of yield benefits by providing wind protection. Innovations for livestock farms included using trees to enhance animal welfare, shade protection, and as a source of fodder. Peer-reviewed journal papers and conference presentations on these and other related topics were developed. Evaluation of agroforestry designs and practices at field- and landscape-scale: a range of publicly available field-scale analysis tools are available on the AGFORWARD website. These include the “CliPick” climate database, and web-applications of the Farm-SAFE and Hi-sAFe model. The results of field- and landscape-scale analysis, written up as peer-reviewed papers, highlight the benefits of agroforestry (relative to agriculture) for biodiversity enhancement and providing regulating ecosystem services, such as for climate and water regulation and purification. Policy development and dissemination: detailed reviews of existing policy and recommendations for future European agroforestry policy have been produced. The support provided is far wider than the single specified agroforestry measures. The recommendations included the collation of existing measures, and that agroforestry systems should not forfeit Pillar I payments. Opportunities for farmlevel and landscape-level measures were also identified. The project results can be found on the project website (www.agforward.eu), a Facebook account (www.facebook.com/AgforwardProject), a Twitter account (https://twitter.com/AGFORWARD_EU), and a quarterly electronic newsletter (http://www.agforward.eu/index.php/en/newsletters-1514.html). The number of national associations in Europe was extended to twelve, and a web-based training resource on agroforestry (http://train.agforward.eu/language/en/agforall/) created. AGFORWARD also supported the Third European Agroforestry Conference in Montpellier in 2016 attracting 287 delegates from 26 countries including many farmers. We also initiated another 21 national conferences or conference sessions on agroforestry, made about 240 oral presentations, 61 poster presentations, produced about 50 news articles, and supported about 87 workshop, training or field-visit activities (in addition to the stakeholder groups)

Defining the clonal dynamics leading to mouse skin tumour initiation.

The changes in cell dynamics after oncogenic mutation that lead to the development of tumours are currently unknown. Here, using skin epidermis as a model, we assessed the effect of oncogenic hedgehog signalling in distinct cell populations and their capacity to induce basal cell carcinoma, the most frequent cancer in humans. We found that only stem cells, and not progenitors, initiated tumour formation upon oncogenic hedgehog signalling. This difference was due to the hierarchical organization of tumour growth in oncogene-targeted stem cells, characterized by an increase in symmetric self-renewing divisions and a higher p53-dependent resistance to apoptosis, leading to rapid clonal expansion and progression into invasive tumours. Our work reveals that the capacity of oncogene-targeted cells to induce tumour formation is dependent not only on their long-term survival and expansion, but also on the specific clonal dynamics of the cancer cell of origin.C.B. is an investigator of WELBIO. A.S-D. and JC.L. are supported by a fellowship of the FNRS and FRIA respectively. B.D.S. and E.H. are supported by the Wellcome Trust (grant number 098357/Z/12/Z and 110326/Z/15/Z). EH is supported by a fellowship from Trinity College, Cambridge. This work was supported by the FNRS, the IUAP program, the Fondation contre le Cancer, the ULB fondation, the foundation Bettencourt Schueller, the foundation Baillet Latour, a consolidator grant of the European Research Council.This is the author accepted manuscript. The final version is available from Nature Publishing Group via http://dx.doi.org/10.1038/nature1906

Esophageal and Gastric Malignancies After Bariatric Surgery: a Retrospective Global Study

Background: Bariatric surgery can influence the presentation, diagnosis, and management of gastrointestinal cancers. Esophagogastric (EG) malignancies in patients who have had a prior bariatric procedure have not been fully characterized. Objective: To characterize EG malignancies after bariatric procedures. Setting: University Hospital, United Kingdom. Methods: We performed a retrospective, multicenter observational study of patients with EG malignancies after bariatric surgery to characterize this condition. Results: This study includes 170 patients from 75 centers in 25 countries who underwent bariatric procedures between 1985 and 2020. At the time of the bariatric procedure, the mean age was 50.2 ± 10 years, and the mean weight 128.8 ± 28.9 kg. Women composed 57.3% (n = 98) of the population. Most (n = 64) patients underwent a Roux-en-Y gastric bypass (RYGB) followed by adjustable gastric band (AGB; n = 46) and sleeve gastrectomy (SG; n = 43). Time to cancer diagnosis after bariatric surgery was 9.5 ± 7.4 years, and mean weight at diagnosis was 87.4 ± 21.9 kg. The time lag was 5.9 ± 4.1 years after SG compared to 9.4 ± 7.1 years after RYGB and 10.5 ± 5.7 years after AGB. One third of patients presented with metastatic disease. The majority of tumors were adenocarcinoma (82.9%). Approximately 1 in 5 patients underwent palliative treatment from the outset. Time from diagnosis to mortality was under 1 year for most patients who died over the intervening period. Conclusion: The Oesophago-Gastric Malignancies After Obesity/Bariatric Surgery study presents the largest series to date of patients developing EG malignancies after bariatric surgery and attempts to characterize this condition.info:eu-repo/semantics/publishedVersio