Bis(benzoato-κ2 O,O′)(1,10-phenanthroline-κ2 N,N′)lead(II) benzoic acid mono­solvate

The reaction of lead acetate, benzoic acid and 1,10-phenanthroline (phen) in aqueous solution yielded the title complex, [Pb(C7H5O2)2(C12H8N2)]·C7H6O2. In the crystal, the PbII ion is hexa­coordinated by two N atoms from one 1,10-phenanthroline ligand and four O atoms from two chelate benzoate anions. If the second benzoate ligand is treated as one coordination site, the overall coordination may be represented as a distorted pseudo-square pyramid. An inter­molecular O—H⋯O hydrogen bond links the solvent benzoic acid mol­ecule with a metal-coordinated benzoate ligand. The shortest Pb⋯Pb distance is 3.864 (4) Å, indicating a weak metal–metal inter­action. Two complex mol­ecules related by an inversion centre form dimeric units via Pb⋯O inter­actions of 3.206 (4) Å

Rapid Transfer Alignment of SINS with Measurement Packet Dropping based on a Novel Suboptimal Estimator

Transfer alignment (TA) is an important step for strapdown inertial navigation system (SINS) starting from a moving base, which utilises the information proposed from the higher accurate and well performed master inertial navigation system. But the information is often delayed or even lost in real application, which will seriously affect the accuracy of TA. This paper models the stochastic measurement packet dropping as an independent identically distributed (IID) Bernoulli random process, and introduces it into the measurement equation of rapid TA, and the influence of measurement packet dropping is analysed. Then, it presents a suboptimal estimator for the estimation of the misalignment in TA considering the random arrival of the measurement packet. Simulation has been done for the performance comparison about the suboptimal estimator, standard Kalman filter and minimum mean squared estimator. The results show that the suboptimal estimator has better performance, which can achieve the best TA accuracy

Luteoloside Inhibits Proliferation of Human Chronic Myeloid Leukemia K562 Cells by Inducing G2/M Phase Cell Cycle Arrest and Apoptosis

Purpose: To investigate the effects of luteoloside on the proliferation of human chronic myeloid leukemia K562 cells and whether luteoloside induces cell cycle arrest and apoptosis in K562 cells.Methods: Luteoloside’s cytotoxicity was assessed using a cell counting kit. Cell cycle distribution was analysed by flow cytometry after propidium iodide (PI) staining. Cell apoptosis was assayed with apoptosis detection kit and Hoechst staining followed by observation under a fluorescence microscope. The expression of cell cycle- and apoptosis-related proteins was examined by Western blot analysis.Results: Luteoloside inhibited the proliferation of K562 cells in a dose- and time- dependent manner (IC50 = 30.7 μM) with less toxicity in a normal human cell line (IC50 = 91.8 μM). Moreover, antiproliferative effect of luteoloside was accompanied with G2/M phase arrest（p ＜ 0.05 or p＜0.01） and apoptosis（p ＜ 0.01 or p ＜ 0.001）. Further studies revealed that the expression level of cyclinB1 was down-regulated by luteoloside treatment. Furthermore, luteoloside treatment also increased proapoptotic protein Bax expression and decreased anti-apoptotic protein Bcl-2 expression.Conclusion: These results suggest that the inhibitory effect of luteoloside on K562 cell proliferation is associated with inducing G2/M phase arrest and apoptosis, and that luteoloside is worth further studying for anticancer potential.Keywords: Luteoloside, Myeloid leukemia, Proliferation, Cell cycle arrest, Apoptosis, Anticance

Pulmonary alveolar type I cell population consists of two distinct subtypes that differ in cell fate.

Pulmonary alveolar type I (AT1) cells cover more than 95% of alveolar surface and are essential for the air-blood barrier function of lungs. AT1 cells have been shown to retain developmental plasticity during alveolar regeneration. However, the development and heterogeneity of AT1 cells remain largely unknown. Here, we conducted a single-cell RNA-seq analysis to characterize postnatal AT1 cell development and identified insulin-like growth factor-binding protein 2 (Igfbp2) as a genetic marker specifically expressed in postnatal AT1 cells. The portion of AT1 cells expressing Igfbp2 increases during alveologenesis and in post pneumonectomy (PNX) newly formed alveoli. We found that the adult AT1 cell population contains both Hopx+Igfbp2+ and Hopx+Igfbp2- AT1 cells, which have distinct cell fates during alveolar regeneration. Using an Igfbp2-CreER mouse model, we demonstrate that Hopx+Igfbp2+ AT1 cells represent terminally differentiated AT1 cells that are not able to transdifferentiate into AT2 cells during post-PNX alveolar regeneration. Our study provides tools and insights that will guide future investigations into the molecular and cellular mechanism or mechanisms underlying AT1 cell fate during lung development and regeneration

Light anti-nuclei production in pp collisions at s\sqrt{s}=7 and 14 TeV

A dynamically constrained coalescence model based on the phase space quantization and classical limit method was proposed to investigate the production of light nuclei (anti-nuclei) in non-single diffractive (NSD) pp collisions at $\sqrt{s}$=7 and 14 TeV. This calculation was based on the final hadronic state in the PYTHIA and PACIAE model simulations, the event sample consisted of 1.2$\times 10^8$ events in both simulations. The PACIAE model calculated $\bar D$ yield of 6.247$\times 10^{-5}$ in NSD pp collisions at $\sqrt{s}$=7 TeV is well comparing with the ALICE rough datum of 5.456$\times 10^{-5}$. It indicated the reliability of proposed method in some extent. The yield, transverse momentum distribution, and rapidity distribution of the $\bar D$, $^3{\bar{He}}$, and $_{\bar\Lambda} ^3{\bar H}$ in NSD pp collisions at $\sqrt{s}$=7 and 14 TeV were predicted by PACIAE and PYTHIA model simulations. The yield resulted from PACIAE model simulations is larger than the one from PYTHIA model. This might reflect the role played by the parton and hadron rescatterings.Comment: 5 pages, 2 figure