Detector induced anisotropies on the angular distribution of gravitational wave sources and opportunities of constraining horizon scale anisotropies

The cosmological principle has been verified using electromagnetic (EM) observations. However its verification with high accuracy is challenging due to various foregrounds and selection effects, and possible violation of the cosmological principle has been reported in the literature. In contrast, gravitational wave (GW) observations are free of these foregrounds and related selection biases. This may enable future GW experiments to test the cosmological principle robustly with full sky distribution of millions of standard bright/dark sirens. However, the sensitivities of GW detectors are highly anisotropic, resulting in significant instrument induced anisotropies in the observed GW catalog. We investigate these instrumental effects for 3rd generation detector networks in term of multipoles $a_{\ell m}$ of the observed GW source distribution, using Monte Carlo simulations. (1) We find that the instrument induced anisotropy primarily exists at the $m=0$ modes on large scales ($\ell \lesssim 10$), with amplitude $\langle |a_{\ell 0}|^2 \rangle \sim 10^{-3}$ for two detectors (ET-CE) and $\sim 10^{-4}$ for three detectors (ET-2CE). This anisotropy is correlated with the sky distribution of signal-to-noise ratio (SNR) and localization accuracy. Such anisotropy sets a lower limit on the detectable cosmological $a_{\ell 0}$. (2) However, we find that the instrument induced anisotropy is efficiently canceled by rotation of the Earth in $m\neq 0$ components of $a_{\ell m}$. Therefore $a_{\ell m}$ ($m\neq 0$) are clean windows to detect cosmological anisotropies. (3) We investigate the capability of 3rd generation GW experiments to measure the cosmic dipole. Through Monte Carlo simulations, we find that cosmic dipole with an amplitude of $\sim 10^{-2}$ reported in the literature can be detected/ruled out by ET-CE and ET-2CE robustly, through the measurement of $a_{11}$.Comment: 7 pages, 6 figures, submitted to MNRA

Analysis of a New Cleaning Technology Based on Supercritical Carbon Dioxide Pre-treatment for Diesel Engine Remanufacturing

Remanufacturing is the rebuilding of a used product to at least its original performance with a warranty that is equivalent or better than that of the newly manufactured product. It is a vital means in improving manufacturing sustainability, through saving raw materials, reducing carbon emissions and conserving product commercial values. As the one of the demanding steps in remanufacturing process, cleaning is also one polluting stage because of the use of environmental detrimental cleaning agents and the large amount of energy consumptions. The specific aim of the work demonstrated in this thesis is to find an alternative cleaning agent that could achieve the effective cleaning of decommissioned engine parts, in an environmentally greener way. More generally, the study in this thesis uses supercritical carbon dioxide (SC-CO₂) as the green agent to reduce the possible environment loads induced by conventional cleaning technologies and further investigate the feasibility of this method in removing other contaminants as an application extension. Organic contaminants, containing greases, lubricating substances and carbon depositions are the most commonly observed contaminants in a decommissioned engine, and they are analysed by a series of analytical methods to validate the feasibility of SC-CO₂ cleaning in this study. Experiments on grease, lubricating oil and paint coatings cleaning are carried out on the supercritical fluid (SCF) facility with the addition of liquid blasting to remove residues after SC-CO₂ treatment. A new cleaning method combining SC-CO₂ pre-treatment and liquid blasting post-treatment processes is proposed and a comparison is conducted between this method and conventional method (thermal decomposition and shot blasting cleaning). Operation parameters for liquid blasting process are determined through single particle blasting test and the comparison demonstrates the new method has a minimal impact on the surface properties of substrate materials, while the conventional cleaning method has a significant negative impact. Ultimately, the comparative life cycle assessment between two methods demonstrates the new cleaning technology can attain a higher cleanliness with better environmental performances. It is concluded that the SC-CO₂ cleaning could provide a “cleaner production” method for remanufacturing

A Decision Tree Approach for Assessing and Mitigating Background and Identity Disclosure Risks

The Facebook/Cambridge Analytica data scandal shows a type of privacy threat where an adversary attacks on a massive number of people without prior knowledge about their background information. Existing studies typically assume that the adversary knew the background information of the target individuals. This study examines the disclosure risk issue in privacy breaches without such an assumption. We define the background disclosure risk and re-identification risk based on the notion of prior and conditional probabilities respectively, and integrate the two risk measures into a composite measure using the Minimum Description Length principle. We then develop a decision-tree pruning algorithm to find an appropriate group size considering the tradeoff between disclosure risk and data utility. Furthermore, we propose a novel tiered generalization method for anonymizing data at the group level. An experimental study has been conducted to demonstrate the effectiveness of our approach

Quantum Circuit AutoEncoder

Quantum autoencoder is a quantum neural network model for compressing information stored in quantum states. However, one needs to process information stored in quantum circuits for many tasks in the emerging quantum information technology. In this work, generalizing the ideas of classical and quantum autoencoder, we introduce the model of Quantum Circuit AutoEncoder (QCAE) to compress and encode information within quantum circuits. We provide a comprehensive protocol for QCAE and design a variational quantum algorithm, varQCAE, for its implementation. We theoretically analyze this model by deriving conditions for lossless compression and establishing both upper and lower bounds on its recovery fidelity. Finally, we apply varQCAE to three practical tasks and numerical results show that it can effectively (1) compress the information within quantum circuits, (2) detect anomalies in quantum circuits, and (3) mitigate the depolarizing noise in quantum devices. This suggests that our algorithm is potentially applicable to other information processing tasks for quantum circuits.Comment: 13 pages, 7 figure

Correlation of caecal microbiome endotoxins genes and intestinal immune cells in Eimeria tenella infection based on bioinformatics

IntroductionThe infection with Eimeria tenella (ET) can elicit expression of various intestinal immune cells, incite inflammation, disrupt intestinal homeostasis, and facilitate co-infection with diverse bacteria. However, the reciprocal interaction between intestinal immune cells and intestinal flora in the progression of ET-infection remains unclear.ObjectiveThe aim of this study was to investigate the correlation between cecal microbial endotoxin (CME)-related genes and intestinal immunity in ET-infection, with subsequent identification of hub potential biomarker and immunotherapy target.MethodsDifferential expression genes (DEGs) within ET-infection and hub genes related to CME were identified through GSE39602 dataset based on bioinformatic methods and Protein-protein interaction (PPI) network analysis. Moreover, immune infiltration was analyzed by CIBERSORT method. Subsequently, comprehensive functional enrichment analyses employing Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway analysis along with Gene Ontology (GO), gene set enrichment analysis (GSEA), and gene set variation analysis (GSVA) were performed.ResultsA total of 1089 DEGs and 25 hub genes were identified and CXCR4 was ultimately identified as a essential CME related potential biomarker and immunotherapy target in the ET-infection. Furthermore, activated natural killer cells, M0 macrophages, M2 macrophages, and T regulatory cells were identified as expressed intestinal immune cells. The functional enrichment analysis revealed that both DEGs and hub genes were significantly enriched in immune-related signaling pathways.ConclusionCXCR4 was identified as a pivotal CME-related potential biomarker and immunotherapy target for expression of intestinal immune cells during ET-infection. These findings have significant implications in elucidating the intricate interplay among ET-infection, CME, and intestinal immunity

Prevalence of inappropriateness of elemene injection for hospitalized cancer patients: a multicenter retrospective study

Background: Elemene injection could provide clinical benefit for the treatment of various cancers, but the clinical evidence is weak. Thus, its wide use in China has raised concerns about the appropriateness of its use.Methods: This was a multicenter retrospective study to evaluate the prevalence of inappropriateness of elemene injection for hospitalized cancer patients. Patients who met the inclusion criteria were retrospectively included, and demographic characteristics were extracted from the hospital information systems. The inappropriateness of elemene injection use was assessed using the preset criteria, and the prevalence was calculated. Multivariate logistic analysis was applied to identify any factors associated with inappropriate use.Results: A total of 275 patients were included in the analysis. The median age was 62 years, and 30.9% were females. The most common cancer was lung cancer (24.0%), and 68.2% of the patients were receiving chemotherapy. The overall prevalence of inappropriateness was 61.8%. The most common reason for inappropriateness was inappropriate indications, and the second was inappropriate doses. Age and oncological department were significant risk factors associated with inappropriate use, while lung cancer, liver cancer and admission to cardiothoracic surgery were associated with a low risk of inappropriate use.Conclusion: The prevalence of inappropriateness among hospitalized elemene injection users was high. More efforts, especially those to improve the appropriateness of indications, should be made to improve the rational use of elemene, as well as other complementary medicines. Physicians should take caution to avoid inappropriate use when prescribing drugs with limited clinical evidence

Soil chemistry, metabarcoding, and metabolome analyses reveal that a sugarcane—Dictyophora indusiata intercropping system can enhance soil health by reducing soil nitrogen loss

IntroductionGreater amounts of fertilizer are applied every year to meet the growing demand for food. Sugarcane is one of the important food sources for human beings.MethodsHere, we evaluated the effects of a sugarcane—Dictyophora indusiata (DI) intercropping system on soil health by conducting an experiment with three different treatments: (1) bagasse application (BAS process), (2) bagasse + DI (DIS process), and (3) the control (CK). We then analyzed soil chemistry, the diversity of soil bacteria and fungi, and the composition of metabolites to clarify the mechanism underlying the effects of this intercropping system on soil properties.Results and discussionSoil chemistry analyses revealed that the content of several soil nutrients such as nitrogen (N) and phosphorus (P) was higher in the BAS process than in the CK. In the DIS process, a large amount of soil P was consumed by DI. At the same time, the urease activity was inhibited, thus slowing down the loss of soil in the DI process, while the activity of other enzymes such as β-glucosidase and laccase was increased. It was also noticed that the content of lanthanum and calcium was higher in the BAS process than in the other treatments, and DI did not significantly alter the concentrations of these soil metal ions. Bacterial diversity was higher in the BAS process than in the other treatments, and fungal diversity was lower in the DIS process than in the other treatments. The soil metabolome analysis revealed that the abundance of carbohydrate metabolites was significantly lower in the BAS process than in the CK and the DIS process. The abundance of D(+)-talose was correlated with the content of soil nutrients. Path analysis revealed that the content of soil nutrients in the DIS process was mainly affected by fungi, bacteria, the soil metabolome, and soil enzyme activity. Our findings indicate that the sugarcane–DIS intercropping system can enhance soil health