Mode Interferences of VLF Waves in the Presence of an Anisotropic Terrestrial Waveguide

It is known that the very low frequency (VLF) signals propagating at long distances over a terrestrial waveguide will experience a diurnal interference across the sunrise and sunset transitions. Early studies indicated that cascaded terrestrial waveguides can be applied to investigate the cycle-clip behaviors of amplitude and phase for VLF waves, with an abrupt effective height change by 20 km to represent the night and day transitions. Based on the knowledge, this chapter starts with some basic concepts on VLF wave propagation in the presence of an anisotropic terrestrial waveguide. Then, by performing the method of field matching at the discontinuous junctions, the coefficients of transmitted and scattered vectors are resulted from two derived matrix equations. Finally, the synthetic fields are calculated to simulate the VLF waves, which are subjected to an oblique geomagnetic field during long-distance propagation. The purpose of the present chapter is to illustrate the disturbing nature during sunrise and sunset for the VLF waves with periodic variations in amplitudes interfered by multimodes over long propagation paths

Genetic polymorphisms: Impact on the risk of fetal alcohol spectrum disorders

Clinical reports on monozygotic and dizygotic twins provided the initial evidence for the involvement of genetic factors in risk vulnerability for fetal alcohol spectrum disorders (FASD) including fetal alcohol syndrome (FAS). Research with selectively bred and inbred rodents, genetic crosses of these lines and strains, and embryo culture studies have further clarified the role of both maternal and fetal genetics in the development of FASD. Research to identify specific polymorphisms contributing to FASD is still at an early stage. To date, polymorphisms of only one of the genes for the alcohol dehydrogenase enzyme family, the ADH1B, have been demonstrated to contribute to FASD vulnerability. In comparison with ADH1B*1, both maternal and fetal ADH1B*2 have been shown to reduce risk for FAS in a mixed ancestry South African population. ADH1B*3 appears to afford protection for FASD outcomes in African-American populations. Other candidate genes should be examined with respect to FASD risk, including those for the enzymes of serotonin metabolism, in particular the serotonin transporter. By its very nature, alcohol teratogenesis is the expression of the interaction of genes with environment. The study of genetic factors in FASD falls within the new field of ecogenetics. Understanding of the array of genetic factors in FASD will be enhanced by future genetic investigations, including case-control, family association, and linkage studies. Birth Defects Research (Part A), 2005

The neurobiology of alcoholism in genetically selected rat models

Rats selectively bred for their tendency to drink large or small quantities of alcohol are a useful model for investigators examining the possible neurobiological processes underlying alcoholism. Studies with the alcohol-preferring (P) and alcohol-nonpreferring (NP) and the high-alcohol-drinking (HAD) and low-alcohol-drinking (LAD) pairs of rat lines developed at Indiana University have illustrated differences in several behavioral and neurobiological characteristics associated with alcohol consumption. Specifically, compared with alcohol-avoiding rats, rats with an affinity for alcohol have a greater sensitivity to the stimulatory effects of low to moderate doses and a reduced sensitivity to the negative effects of high doses. Rats that voluntarily drink large quantities of alcohol also acquire tolerance to alcohol’s aversive effects. In addition, these rats differ from their alcohol-avoiding counterparts in the levels of several chemical mediators (i.e., neurotransmitters) found in the brain, including serotonin, dopamine, gamma-aminobutyric acid (GABA), and the endogenous opioids

A Social Referral Mechanism for Job Reference Recommendation

Recently, with the popularity of various social media, this new trend of information technologies has impacted our lives, redefined the way we interact with each other, and facilitated the communication and influence cross different social groups, such as enhancing the power of social search and appraisal. _x000D_ In this research, we mainly focus on this mystery process of information exchanges existing long ago on the base of sociology and apply this power in the field of job seeking. Considering the factors of both willingness and influence, we generate the list of proper reference candidates to desired job for job seekers to provide more job-related information or to be referrals. Integrating the knowledge of human resources management, we implement this social referral application with the support of information technologies and strive to enrich the service of social media, turning the passively searching for job seeking to actively consulting for exclusively job information._x000D

Gender difference in functional activity of 4-months-old infants during sleep: A functional near-infrared spectroscopy study

Sex differences emerge early in infancy. A number of earlier studies have investigated the resting-state network of infant sleep states, and there have been many studies using functional near-infrared spectroscopy (fNIRS) to examine the effects of infant language learning on changes in oxyhemoglobin and deoxyhemoglobin levels. However, studies examining sex differences from the resting-state network of infant sleep states are scarce. This study uses an open access dataset of task-free hemodynamic activity in 4-month-old infants during sleep by fNIRS, to identify some difference between male and female infants. We used Power Spectral Density showing at which frequencies the data variation/variance is high. We have also analyzed some gender differences by analyzing the relationship between individual channels, the degree of activation, etc. The results of this study showed that female and male infants had different Power Spectral Density for oxyhemoglobin and deoxyhemoglobin at rest, showing stronger differences at frontoparietal network, somatomotor network, visual network and dorsal network. This may be due to the differences in the timing or extent of development of those networks. These differences will provide some assistance in future studies of the early education of male and female infants

The alcohol-preferring (P) and high-alcohol-drinking (HAD) rats – Animal Models of Alcoholism

The objective of this article is to review the literature on the utility of using the selectively bred alcohol-preferring (P) and high-alcohol-drinking (HAD) lines of rats in studies examining high alcohol drinking in adults and adolescents, craving-like behavior, and the co-abuse of alcohol with other drugs. The P line of rats meets all of the originally proposed criteria for a suitable animal model of alcoholism. In addition, the P rat exhibits high alcohol-seeking behavior, demonstrates an alcohol deprivation effect (ADE) under relapse drinking conditions, consumes amounts of ethanol during adolescence equivalent to those consumed in adulthood, and co-abuses ethanol and nicotine. The P line also exhibits excessive binge-like alcohol drinking, attaining blood alcohol concentrations (BACs) of 200 mg% on a daily basis. The HAD replicate lines of rats have not been as extensively studied as the P rats. The HAD1,2 rats satisfy several of the criteria for an animal model of alcoholism, e.g., these rats will voluntarily consume ethanol in a free-choice situation to produce BACs between 50–200 mg%. The HAD1,2 rats also exhibit an ADE under repeated relapse conditions, and will demonstrate similar levels of ethanol intake during adolescence as seen in adults. Overall, the P and HAD1,2 rats have characteristics attributed to an early onset alcoholic, and can be used to study various aspects of alcohol use disorders