Effect of cannabis smoking on lung function and respiratory symptoms: a structured literature review

As cannabis use increases, physicians need to be familiar with the effects of both cannabis and tobacco on the lungs. However, there have been very few long-term studies of cannabis smoking, mostly due to legality issues and the confounding effects of tobacco. It was previously thought that cannabis and tobacco had similar long-term effects as both cause chronic bronchitis. However, recent large studies have shown that, instead of reducing forced expiratory volume in 1 s and forced vital capacity (FVC), marijuana smoking is associated with increased FVC. The cause of this is unclear, but acute bronchodilator and anti-inflammatory effects of cannabis may be relevant. Bullous lung disease, barotrauma and cannabis smoking have been recognised in case reports and small series. More work is needed to address the effects of cannabis on lung function, imaging and histological changes

Quantum Fully Homomorphic Encryption With Verification

Fully-homomorphic encryption (FHE) enables computation on encrypted data while maintaining secrecy. Recent research has shown that such schemes exist even for quantum computation. Given the numerous applications of classical FHE (zero-knowledge proofs, secure two-party computation, obfuscation, etc.) it is reasonable to hope that quantum FHE (or QFHE) will lead to many new results in the quantum setting. However, a crucial ingredient in almost all applications of FHE is circuit verification. Classically, verification is performed by checking a transcript of the homomorphic computation. Quantumly, this strategy is impossible due to no-cloning. This leads to an important open question: can quantum computations be delegated and verified in a non-interactive manner? In this work, we answer this question in the affirmative, by constructing a scheme for QFHE with verification (vQFHE). Our scheme provides authenticated encryption, and enables arbitrary polynomial-time quantum computations without the need of interaction between client and server. Verification is almost entirely classical; for computations that start and end with classical states, it is completely classical. As a first application, we show how to construct quantum one-time programs from classical one-time programs and vQFHE.Comment: 30 page

Literature review and analysis of the application of health outcome assessment instruments in Chinese medicine

OBJECTIVE: To evaluate the application of health assessment instruments in Chinese medicine. METHODS: According to a pre-defined search strategy, a comprehensive literature search for all articles published in China National Knowledge Infrastructure databases was conducted. The resulting articles that met the defined inclusion and exclusion criteria were used for analysis. RESULTS: A total of 97 instruments for health outcome assessment in Chinese medicine have been used in fundamental and theoretical research, and 14 of these were also used in 29 clinical trials that were randomized controlled trials, or descriptive or cross-sectional studies. In 2 152 Chinese medicine-based studies that used instruments in their methodology, more than 150 questionnaires were identified. Among the identified questionnaires, 51 were used in more than 10 articles (0.5%). Most of these instruments were developed in Western countries and few studies (4%) used the instrument as the primary evidence for their conclusions. CONCLUSION: Usage of instruments for health outcome assessment in Chinese medicine is increasing rapidly; however, current limitations include selection rationale, result interpretation and standardization, which must be addressed accordingly

Cervical lymph node metastatic patterns of squamous carcinomas in the upper aerodigestive tract

The radical neck dissection specimens of 384 ethnically Chinese patients with different primary squamous carcinomas in the head and neck region were studied. Over 50 per cent of the specimens showed metastatic disease at one level in the neck. For oral cavity carcinoma, the levels of metastasis frequently involved were I, II and III while for carcinoma of the oropharynx, hypopharynx and larynx, the levels were II, III and IV. Extracapsular spread was present in 112/384 of patients (29 per cent) and this increased with advancing N-stages. Based on these findings, different selective neck dissections could be used for patients harbouring different primary head and neck carcinomas with limited neck disease.published_or_final_versio

Effect of oxygen stoichiometry on microstructural and magnetic properties of FePt/TaOx bilayer fabricated by ion-beam-bombardment deposition

published_or_final_versio

Low temperature vortex liquid in La2−xSrxCuO4\rm La_{2-x}Sr_xCuO_4

In the cuprates, the lightly-doped region is of major interest because superconductivity, antiferromagnetism, and the pseudogap state \cite{Timusk,Lee,Anderson} come together near a critical doping value $x_c$. These states are deeply influenced by phase fluctuations \cite{Emery} which lead to a vortex-liquid state that surrounds the superconducting region \cite{WangPRB01,WangPRB06}. However, many questions \cite{Doniach,Fisher,FisherLee,Tesanovic,Sachdev} related to the nature of the transition and vortex-liquid state at very low tempera- tures $T$ remain open because the diamagnetic signal is difficult to resolve in this region. Here, we report torque magnetometry results on $\rm La_{2-x}Sr_xCuO_4$ (LSCO) which show that superconductivity is lost at $x_c$ by quantum phase fluctuations. We find that, in a magnetic field $H$, the vortex solid-to-liquid transition occurs at field $H_m$ much lower than the depairing field $H_{c2}$. The vortex liquid exists in the large field interval $H_m \ll H_{c2}$, even in the limit $T\to$0. The resulting phase diagram reveals the large fraction of the $x$-$H$ plane occupied by the quantum vortex liquid.Comment: 6 pages, 4 figures, submitted to Nature Physic

Fully Automatable Two-dimensional HILIC–RP Liquid Chromatography with Online Tandem Mass Spectrometry for Shotgun Proteomics

Poster PresentationConference theme: Proteomics: Better for lifeMultidimensional liquid chromatography (MDLC) which multiples the resolution power of individual dimension with high orthogonality is a very efficient front-end separation method for analyzing the digests of complex biological samples. Among the existing two dimensional liquid chromatography (2DLC) systems, the combination of hydrophilic interaction liquid chromatography (HILIC) followed by low-pH reversed-phase (RP)LC (HILIC-RP) has very high orthogonality and is a very promising 2DLC method. Herein, a fully automatable two-dimensional (2D) liquid chromatography system was developed for shotgun proteomics analyses, which coupling the hydrophilic interaction liquid chromatography (HILIC) TSKgel Amide 80 (a non-ionic type) with the low-pH reversedphase (RP) chromatography. The performance of the 2D HILIC-RP LC platform was investigated at both pH 6.8 (neutral pH) and pH 2.7 (acidic pH) of the first dimension HILIC column by duplicate analyses of a Rat pheochromocytoma lysates.Online coupling of the neutral-pH HILIC and RP systems outperformedthe acidic HILIC–RP combination,resulting in 18.4% (1914 versus 1617 nonredundant proteins) and 41.6% (12,989 versus 9172unique peptides) increases in the number of identified proteins and peptides. To further test the established 2D HILIC-RP platform, we identified 2648 non-redundant proteins from triplicate analyses of a Saccharomyces cerevisiae lysate, with the detected protein abundances spanning from approximately41 to 106 copies per cell, which contained up to 2164 different validated protein species with a dynamic range of concentrations up to approximately 104. Herein, this studyestablished a fully automated 2D liquid chromatography platform to enable onlinecoupling of different HILIC and RP chromatography systems, thereby expanding the choice and application of multidimensional liquid chromatography for shotgun proteomics.published_or_final_versio

Physiology and cell biology of acupuncture observed in calcium signaling activated by acoustic shear wave

This article presents a novel model of acupuncture physiology based on cellular calcium activation by an acoustic shear wave (ASW) generated by the mechanical movement of the needle. An acupuncture needle was driven by a piezoelectric transducer at 100 Hz or below, and the ASW in human calf was imaged by magnetic resonance elastography. At the cell level, the ASW activated intracellular Ca 2+ transients and oscillations in fibroblasts and endothelial, ventricular myocytes and neuronal PC-12 cells along with frequency-amplitude tuning and memory capabilities. Monitoring in vivo mammalian experiments with ASW, enhancement of endorphin in blood plasma and blocking by Gd 3+ were observed; and increased Ca 2+ fluorescence in mouse hind leg muscle was imaged by two-photon microscopy. In contrast with traditional acupuncture models, the signal source is derived from the total acoustic energy. ASW signaling makes use of the anisotropy of elasticity of tissues as its waveguides for transmission and that cell activation is not based on the nervous system. © 2011 The Author(s).published_or_final_versionSpringer Open Choice, 21 Feb 201

Single shot cathode transverse momentum imaging in high brightness photoinjectors

In state of the art photoinjector electron sources, thermal emittance from photoemission dominates the final injector emittance. Therefore, low thermal emittance cathode developments and diagnostics are very important. Conventional thermal emittance measurements for the high gradient gun are time-consuming and thus thermal emittance is not measured as frequently as quantum efficiency during the lifetime of photocathodes, although both are important properties for the photoinjector optimizations. In this paper, a single shot measurement of photoemission transverse momentum, i.e., thermal emittance per rms laser spot size, is proposed for photocathode rf guns. By tuning the gun solenoid focusing, the electrons' transverse momenta at the cathode are imaged to a downstream screen, which enables a single shot measurement of both the rms value and the detailed spectra of the photoelectrons' transverse momenta. Both simulations and proof of principle experiments are reported