Experimental studies on shock wave interactions with flexible surfaces and development of flow diagnostic tools

Nowadays, light-weight composite materials have increasingly used for high-speed flight vehicles to improve their performance and efficiency. At supersonic speed, sonic fatigue, panel flutter, severe instabilities, and even catastrophic structural failure would occur due to the shock wave impingement on several flexible components of a given structural system either internally or externally. Therefore, investigation on shock wave interaction with flexible surfaces is crucial for the safety and performance of high-speed flight vehicles. This work aims to investigate the mechanism of shock wave interaction with flexible surfaces with and without the presence of the boundary layer. The first part involves the shock wave generated by supersonic starting jets interaction with flexible surfaces and the other one focuses on shock wave and boundary layer interaction (SBLI) over flexible surfaces. A novel miniature and cost-effective shock tube driven by detonation transmission tubing was designed and manufactured to simulate the supersonic starting jet and investigate the interaction of a supersonic starting jet with flexible surfaces. To investigate the characterization of this novel type shock tube, the pressure-time measurement in the driven section and the time-resolved shadowgraph were performed. The result shows that the flow structure from the open end of the shock tube driven by detonation transmission tubing agrees with that of conventional compressed-gas driven shock tubes. Moreover, this novel type of shock tube has good repeatability of less than 3% with a Mach number range of 1.29-1.58 when the weight of the NONEL explosive mixture varies from 3.6mg to 12.6mg. An unsteady background oriented schlieren (BOS) measurement system and a sprayable Polymer-Ceramic unsteady pressure sensitive paint (PC-PSP) system were developed. The preliminary BOS result in a supersonic wind tunnel shows that the sensitivity of the BOS system is good enough to visualize weak density variations caused by expansion waves, boundary layer, and weak oblique shocks. Additionally, compared with the commercial PC-PSP from Innovative Scientific Solutions Incorporated (ISSI), the in-house developed unsteady PSP system has higher pressure sensitivity, lower temperature sensitivity, and photo-degradation rate. To identify the shock movement, distortion and unsteadiness during the processes of the supersonic starting jet impingement and shock wave boundary layer interaction (SBLI) over flexible surfaces, an image processing scheme involving background subtraction in the frequency domain, filtering, resampling, edge detection, adaptive threshold, contour detection, feature extraction, and fitting was proposed and applied to process shadowgraph and schlieren sequences automatically. A large shadowgraph data set characterized by low signal to noise ratio (SNR) and small spatial resolution (312×260-pixel), was used to validate the proposed scheme. The result proves that the aforementioned image processing scheme can detect, track, localize, and fit shock waves in a subpixel accuracy. The mechanism of the interaction between the initial shock wave from a supersonic starting jet and flexible surfaces was investigated based on a square shock tube driven by detonation transmitting tube. Compared with that of the solid plate case, flexible surfaces can delay the shock reflection process because of the flexible panel deformation generated by the pressure difference between the top and the bottom. The delay time is around 8µs in the case of 0.1mm thick flexible surface, whereas it declines to around 4µs in the case of 0.3mm thick flexible surface because of the lower flexibility and deformation magnitude. However, interestingly, the propagation velocity of the reflected shock wave is basically the same for the solid plate and flexible panels, which means the flexible surface doesn’t reduce the strength of the reflection wave, although it delays its propagation. Also, there is not an apparent difference in the velocity of the reflected shock wave in the case of different incident shock Mach numbers when Ms varying from 1.22 to 1.54. These experimental results from this study are useful for validating numerical codes that are used for understanding fluid-structure interaction processes

Hardware/software partitioning algorithm based on the combination of genetic algorithm and tabu search

To solve the hardware/software (HW/SW) partitioning problem of a single Central Processing Unit (CPU) system, a hybrid algorithm of Genetic Algorithm (GA) and Tabu Search(TS) is studied. Firstly, the concept hardware orientation is proposed and then used in creating the initial colony of GA and the mutation, which reduces the randomicity of initial colony and the blindness of search. Secondly, GA is run, the crossover and mutation probability become smaller in the process of GA, thus they not only ensure a big search space in the early stages, but also save the good solution for later browsing. Finally, the result of GA is used as initial solution of TS, and tabu length adaptive method is put forward in the process of TS, which can improve the convergence speed. From experimental statistics, the efficiency of proposed algorithm outperforms comparison algorithm by up to 25% in a large-scale problem, what is more, it can obtain a better solution. In conclusion, under specific conditions, the proposed algorithm has higher efficiency and can get better solutions

miRecords: an integrated resource for microRNA–target interactions

MicroRNAs (miRNAs) are an important class of small noncoding RNAs capable of regulating other genes’ expression. Much progress has been made in computational target prediction of miRNAs in recent years. More than 10 miRNA target prediction programs have been established, yet, the prediction of animal miRNA targets remains a challenging task. We have developed miRecords, an integrated resource for animal miRNA–target interactions. The Validated Targets component of this resource hosts a large, high-quality manually curated database of experimentally validated miRNA–target interactions with systematic documentation of experimental support for each interaction. The current release of this database includes 1135 records of validated miRNA–target interactions between 301 miRNAs and 902 target genes in seven animal species. The Predicted Targets component of miRecords stores predicted miRNA targets produced by 11 established miRNA target prediction programs. miRecords is expected to serve as a useful resource not only for experimental miRNA researchers, but also for informatics scientists developing the next-generation miRNA target prediction programs. The miRecords is available at http://miRecords.umn.edu/miRecords

Characterization of a novel open-ended shock tube facility based on detonation transmission tubing

This paper proposes and demonstrates a novel shock tube driven by commercially available detonation transmission tubing in a safe, repeatable, and controllable manner for laboratory scale experiments. A circular cross-sectional open-ended shock tube (inner-diameter D = 22 mm) driven by detonation transmission tubing was used to investigate the working principle of this novel shock tube using a dynamic pressure transducer and time-resolved shadowgraph photography. Specifically, the shock Mach number, repeatability, and flow structure generated from the tube exit were characterized. The experimental result shows that the flow structure including an initial shock wave, a vortex ring, an embedded shock, and an oblique shock pattern is similar to that of the conventional compressed-gas driven shock tubes. Furthermore, the shock tube has good repeatability of less than 2% with a shock Mach number up to 1.58. The versatile and cost-effective nature of the shock tube driven by detonation transmission tubing opens a new horizon for shock wave-assisted interdisciplinary applications

Automatic shock detection, extraction and fitting in schlieren and shadowgraph visualization

No abstract available

Population Effect Model Identifies Gene Expression Predictors of Survival Outcomes in Lung Adenocarcinoma for Both Caucasian and Asian Patients

Background: We analyzed and integrated transcriptome data from two large studies of lung adenocarcinomas on distinct populations. Our goal was to investigate the variable gene expression alterations between paired tumor-normal tissues and prospectively identify those alterations that can reliably predict lung disease related outcomes across populations. Methods: We developed a mixed model that combined the paired tumor-normal RNA-seq from two populations. Alterations in gene expression common to both populations were detected and validated in two independent DNA microarray datasets. A 10-gene prognosis signature was developed through a l1 penalized regression approach and its prognostic value was evaluated in a third independent microarray cohort. Results: Deregulation of apoptosis pathways and increased expression of cell cycle pathways were identified in tumors of both Caucasian and Asian lung adenocarcinoma patients. We demonstrate that a 10-gene biomarker panel can predict prognosis of lung adenocarcinoma in both Caucasians and Asians. Compared to low risk groups, high risk groups showed significantly shorter overall survival time (Caucasian patients data: HR = 3.63, p-value = 0.007; Asian patients data: HR = 3.25, p-value = 0.001). Conclusions: This study uses a statistical framework to detect DEGs between paired tumor and normal tissues that considers variances among patients and ethnicities, which will aid in understanding the common genes and signalling pathways with the largest effect sizes in ethnically diverse cohorts. We propose multifunctional markers for distinguishing tumor from normal tissue and prognosis for both populations studied

Hardware/software partitioning algorithm based on the combination of genetic algorithm and tabu search

To solve the hardware/software (HW/SW) partitioning problem of a single Central Processing Unit (CPU) system, a hybrid algorithm of Genetic Algorithm (GA) and Tabu Search(TS) is studied. Firstly, the concept hardware orientation is proposed and then used in creating the initial colony of GA and the mutation, which reduces the randomicity of initial colony and the blindness of search. Secondly, GA is run, the crossover and mutation probability become smaller in the process of GA, thus they not only ensure a big search space in the early stages, but also save the good solution for later browsing. Finally, the result of GA is used as initial solution of TS, and tabu length adaptive method is put forward in the process of TS, which can improve the convergence speed. From experimental statistics, the efficiency of proposed algorithm outperforms comparison algorithm by up to 25% in a large-scale problem, what is more, it can obtain a better solution. In conclusion, under specific conditions, the proposed algorithm has higher efficiency and can get better solutions

Increased extreme precipitation in Chinese deserts from 1960 to 2018

Extreme precipitation over drylands, especially deserts, has been often observed. The precipitation changes in Chinese deserts have been rarely studied. Here, we use a daily grid precipitation dataset generated via weather station data (0.25° horizontal grid spacing) to investigate the spatial and temporal changes in extreme precipitation in Chinese deserts. The extreme precipitation based on the changes in the total precipitation (PRCPTOT) and the annual‐maximum daily precipitation (Rx1day) in the Chinese desert exhibits markedly increasing trends and presents a spatial distribution of wetting in the western deserts and drying in the eastern deserts. The increase in extreme precipitation could minimize wind erosion and intensify dune stabilization in the western Chinese deserts

Development of Unsteady Background-oriented Schlieren System in an Indraft Supersonic Wind Tunnel

To visualize the flow in the test section of an indraft supersonic wind tunnel in the University of Glasgow as long as possible, a background-oriented schlieren system was built up preliminarily. A MATLAB program based on a random dot algorithm developed in this study provides a fully customizable tool to generate background patterns with different sizes and dot densities. Background patterns produced by the in-house developed program then can be printed by a common ink-jet printer. To enhance the signal-noise ratio of the measurement system, white reflective film sheets, or semi-transparent paper can be employed. The correlation algorithm base on fast Fourier transform that is also applicable for PIV was chosen to process background oriented schlieren images. A validation test was performed to visualize the flow structure around a Pitot tube at M = 2.0. The experimental result proves that the BOS system established in this study is capable of visualizing the supersonic flow structure around the Pitot tube and sensitive enough to reveal weak density changes produced by the boundary layer, expansion waves, and weak oblique shock waves. Next, the current BOS system will be improved further by increasing the intensity of light sources to shorten the exposure time, using new cameras with better spatial resolution, and optimizing the background pattern

Choline metabolism and its implications in cancer

Choline, a quintessential quaternary ammonium compound, plays a cardinal role in several pivotal biological mechanisms, chiefly in safeguarding cell membrane integrity, orchestrating methylation reactions, and synthesizing vital neurotransmitters. This systematic review meticulously dissects the complex interplay between choline metabolism and its profound implications in oncology. The exposition is stratified into three salient dimensions: Initially, we delve into the intricacies of choline metabolism, accentuating its indispensability in cellular physiology, the enzymatic labyrinth governing its flux, and the pivotal cellular import mechanisms. Subsequently, we elucidate the contemporary comprehension of choline metabolism in the cancer paradigm, traversing its influence from inception to the intricate metamorphosis during oncogenic progression, further compounded by dysregulated enzyme activities and aberrant signaling cascades. Conclusively, we illuminate the burgeoning potential of choline-centric metabolic imaging modalities, notably magnetic resonance spectroscopy (MRS) and positron emission tomography (PET), as avant-garde tools for cancer diagnostics and therapeutic trajectory monitoring. Synoptically, the nuanced perturbations in choline metabolism in neoplastic entities unfurl critical insights, potentially heralding paradigm shifts in diagnostic and therapeutic oncological stratagems. A deeper foray into this realm is anticipated to fortify our molecular understanding and refine intervention modalities in cancer theranostics