OMAE2004-51016 RISK BASED INSPECTION AND REPAIR OPTIMIZATION OF SHIP STRUCTURES CONSIDERING CORROSION EFFECTS

ABSTRACT A theoretical framework of risk based optimal inspection and repair planning is proposed for the ship structures subjected to corrosion deterioration. The planning problem is formulated as an optimization problem where the expected lifetime costs were minimized with a constraint on the minimum acceptable reliability index. The safety margins are established for the inspection events, the repair events and the failure events for ship structures. Moreover, the formulae are derived to calculate failure probabilities and repair probabilities. Based on them, a component subjected to pitting corrosion is investigated to illustrate the process of selecting the optimal inspection and repair strategy. Furthermore, some sensitivity studies were provided. The results show that the optimal inspection instants should take place before the reliability index reaches the minimum acceptable reliability index. The optimal target failure probability is . In addition, a balance can be achieved between the risk cost and total expected inspection and repair costs by using the risk based optimal inspection and repair method, which is very effective in selecting the optimal inspection and repair strategy

Structure-based Discovery of Novel Small Molecule Wnt Signaling Inhibitors by Targeting the Cysteine-rich Domain of Frizzled.

Frizzled is the earliest discovered glycosylated Wnt protein receptor and is critical for the initiation of Wnt signaling. Antagonizing Frizzled is effective in inhibiting the growth of multiple tumor types. The extracellular N terminus of Frizzled contains a conserved cysteine-rich domain that directly interacts with Wnt ligands. Structure-based virtual screening and cell-based assays were used to identify five small molecules that can inhibit canonical Wnt signaling and have low IC50 values in the micromolar range. NMR experiments confirmed that these compounds specifically bind to the Wnt binding site on the Frizzled8 cysteine-rich domain with submicromolar dissociation constants. Our study confirms the feasibility of targeting the Frizzled cysteine-rich domain as an effective way of regulating canonical Wnt signaling. These small molecules can be further optimized into more potent therapeutic agents for regulating abnormal Wnt signaling by targeting Frizzled

Evolution of palladium sulfide phases during thermal treatments and consequences for acetylene hydrogenation

We thank Diamond Light Source for beamline access B18 (SP15151-5) and are grateful to the expertise and help provided by Dr Emma Gibson (UK Catalysis Hub, Harwell) and Diego Gianolio (Beamline Scientist on B18) whilst data collecting. XPS data collection was performed at the EPSRC National Facility for XPS (‘HarwellXPS’), operated by Cardiff University and UCL, under contract No. PR16195. We would also like to thank Prof. Philip R. Davies for helpful discussions on XPS data analysis. This work was partly supported by the National Key Research and Development Program of China (2016YFB0301601), National Natural Science Foundation of China.Peer reviewedPostprin

Metal-Organic Framework-Derived Ni-S/C Catalysts for Selective Alkyne Hydrogenation

Acknowledgments This work was financially supported by the National Natural Science Foundation of China (22278017), the Fundamental Research Funds for the Central Universities (buctrc202303, JD2325), and the Young Elite Scientists Sponsorship Program by BAST (No. BYESS2023087).Peer reviewedPostprin

Palladium phosphide nanoparticles as highly selective catalysts for the selective hydrogenation of acetylene

This work was supported by the National Key Research and Development Program of China (2016YFB0301601), National Natural Science Foundation of China.Peer reviewedPostprin

Comparison of Pd and Pd4S based catalysts for partial hydrogenation of external and internal butynes

Acknowledgements This work was supported by the National Natural Science Foundation of China (21908002), project funded by China Postdoctoral Science Foundation (2019M660416) and the Fundamental Research Funds for the Central Universities (buctrc201921).Peer reviewedPostprin

Adsorbate-Induced Structural Evolution of Pd Catalyst for Selective Hydrogenation of Acetylene

ACKNOWLEDGMENT: This work was financially supported by National Natural Science Foundation of China (21908002), project funded by China Postdoctoral Science Foundation (2019M660416, 2020T130045) and the Fundamental Research Funds for the Central Universities (buctrc201921, JD2004, XK1802-6). We would like to thank the UK catalysis Hub for help collecting the XAS.Peer reviewedPostprin

Highly Selective and Stable Isolated Non-Noble Metal Atom Catalysts for Selective Hydrogenation of Acetylene

ACKNOWLEDGMENTS This work was financially supported by National Natural Science Foundation of China (21908002) and the Fundamental Research Funds for the Central Universities (buctrc201921, JD2108).Peer reviewedPostprin

Understanding the Role of Coordinatively Unsaturated Al3+ Sites on Nanoshaped Al2O3 for Creating Uniform Ni–Cu Alloys for Selective Hydrogenation of Acetylene

Acknowledgments This work was financially supported by the National Key R&D Program of China (2021YFB3801600), the National Natural Science Foundation of China (22218017), and the Fundamental Research Funds for the Central Universities (buctrc201921, JD2223). We acknowledge the Beijing Synchrotron Radiation Facility (BSRF) for providing the experimental resources for XAS experiments.Peer reviewedPostprin

Mitigating catalyst deactivation in selective hydrogenation by enhancing dispersion and utilizing reaction heat effect

ACKNOWLEDGMENT This work was financially supported by National Key R&D Program of China (2021YFB3801600), National Natural Science Foundation of China (21908002), and Fundamental Research Funds for the Central Universities (buctrc201921, JD2223).Peer reviewedPostprin