Holographic Mutual Information of Two Disjoint Spheres

We study quantum corrections to holographic mutual information for two disjoint spheres at a large separation by using the operator product expansion of the twist field. In the large separation limit, the holographic mutual information is vanishing at the semiclassical order, but receive quantum corrections from the fluctuations. We show that the leading contributions from the quantum fluctuations take universal forms as suggested from the boundary CFT. We find the universal behavior for the scalar, the vector, the tensor and the fermionic fields by treating these fields as free fields propagating in the fixed background and by using the 1/n prescription. In particular, for the fields with gauge symmetries, including the massless vector boson and massless graviton, we find that the gauge parts in the propagators play indispensable role in reading the leading order corrections to the bulk mutual information.Comment: 37 pages, 1 figure; significant revisions, corrected the discussions on the computations of the mutual information in CFT, conclusions unchange

The Swr1 chromatin-remodeling complex prevents genome instability induced by replication fork progression defects.

Genome instability is associated with tumorigenesis. Here, we identify a role for the histone Htz1, which is deposited by the Swr1 chromatin-remodeling complex (SWR-C), in preventing genome instability in the absence of the replication fork/replication checkpoint proteins Mrc1, Csm3, or Tof1. When combined with deletion of SWR1 or HTZ1, deletion of MRC1, CSM3, or TOF1 or a replication-defective mrc1 mutation causes synergistic increases in gross chromosomal rearrangement (GCR) rates, accumulation of a broad spectrum of GCRs, and hypersensitivity to replication stress. The double mutants have severe replication defects and accumulate aberrant replication intermediates. None of the individual mutations cause large increases in GCR rates; however, defects in MRC1, CSM3 or TOF1 cause activation of the DNA damage checkpoint and replication defects. We propose a model in which Htz1 deposition and retention in chromatin prevents transiently stalled replication forks that occur in mrc1, tof1, or csm3 mutants from being converted to DNA double-strand breaks that trigger genome instability

A possible Macronova in the late afterglow of the `long-short' burst GRB 060614

Long-duration ($>2$ s) $\gamma$-ray bursts that are believed to originate from the death of massive stars are expected to be accompanied by supernovae. GRB 060614, that lasted 102 s, lacks a supernova-like emission down to very stringent limits and its physical origin is still debated. Here we report the discovery of near-infrared bump that is significantly above the regular decaying afterglow. This red bump is inconsistent with even the weakest known supernova. However, it can arise from a Li-Paczy\'{n}ski macronova $-$ the radioactive decay of debris following a compact binary merger. If this interpretation is correct GRB 060614 arose from a compact binary merger rather than from the death of a massive star and it was a site of a significant production of heavy r-process elements. The significant ejected mass favors a black hole-neutron star merger but a double neutron star merger cannot be ruled out.Comment: Minor revision; The version published in Nature Communication

Market Interdependence In The Pacific Basin Region: Internal Drives And External Influences

This paper examines equity market linkages in the Pacific Basin (PB) region and their relations to other mature markets and also assesses the response of these markets to major global events. Results from weekly data for market pairs and for the region as a whole consistently suggest that markets in the PB region are internally interdependent and exhibit significant external relations mainly with the US (rather than Japan). The presence of potent market linkages seems inconsistent with market efficiency provided that implied trading rules yield risk-adjusted excess returns. However, the results further indicate that PB market linkages, both internally within the region and externally with the US, have endured considerable weaknesses particularly since the September 11, 2001 terrorist attack. Such recent weakening of equity market linkages may have strengthened diversification benefits available to US investors from investing in the PB region. We also obtain evidence indicating that three main factors significantly explain the differing degrees of market linkages across countries in the PB region; namely, exchange-rate volatility, equity market volatility and money-market interlink

Optimiranje podloge za proizvodnju celulaze s pomoću mutiranog soja Trichoderma reesei WX-112 metodom odzivnih površina

The mutant strain Trichoderma reesei WX-112 with high cellulase activity was isolated by a newly invented plate. The mutant’s ability to produce cellulase increased 1.95 times after the treatment with UV and N-methyl-N’-nitro-N-nitrosoguanidine (MNNG). Also, the medium composition was optimized using response surface methodology (RSM). A fractional factorial design (26–2) was applied to elucidate the medium components that significantly affect cellulase production. The concentration of Avicel and soybean cake flour in the medium were significant factors. The steepest ascent method was used to locate the optimal domain and a central composite design was used to estimate the quadratic response surface from which the factor levels for maximum production of cellulase were determined. The composition of fermentation medium optimized with response surface methodology was (in g/L): wheat bran 30, Avicel 36.4, soybean cake flour 24.7, KH2PO4 4 and corn steep flour 5. Compared to the original medium, the cellulase activity increased from 7.2 to 10.6 IU/mL.Mutirani soj Trichoderma reesei WX-112, velike celulazne aktivnosti, izoliran je na tek izumljenoj ploši za uzgoj. Sposobnost mutiranoga soja da proizvodi celulazu povečala se 1,95 puta nakon obrade UV-zračenjem i N-metil-N’-nitro-N nitrozogvanidinom (MNNG). Sastav podloge optimiran je metodom odzivnih površina. Reducirani faktorski plan (26–2) primijenjen je kako bi se objasnio značajan utjecaj komponenata na proizvodnju celulaze, a osobito koncentracija Avicela i odmašćenog sojinog brašna u podlozi. Metodom najstrmijeg uspona utvrđeno je optimalno područje, a centralno uređenim planom određena je kvadratna odzivna površina prema kojoj se vide razine faktora za maksimalnu proizvodnju celulaze. Podloga optimirana metodom odzivnih površina sadržavala je 30 g/L pšeničnih mekinja, 36,4 g/L Avicela, 24,7 g/L odmašćenog sojinog brašna, 4 g/L KH2PO4 i 5 g/L kukuruzne mokre meljave. U usporedbi s početnom podlogom celulazna se aktivnost povećala od 7,2 na 10,6 IU/m

Identification of Selective Tubulin Inhibitors as Potential Anti-Trypanosomal Agents

The potency of a series of sulfonamide tubulin inhibitors against the growth of Trypanosoma brucei (T. brucei), as well as human cancer and primary fibroblast cells were evaluated with the aim of determining whether compounds that selectively inhibit parasite proliferation could be identified. Several compounds showed excellent selectivity against T. brucei growth, and have the potential to be used for the treatment of Human African trypanosomiasis. A T. brucei tubulin protein homology model was built based on the crystal structure of the bovine tubulin. The colchicine-binding domain, which is also the binding site of the tested sulfonamide tubulin inhibitors, showed clear differences between the tubulin structures and presumably explained the selectivity of the compounds