23,085 research outputs found
Hydrogen and fuel cell technologies for heating: A review
The debate on low-carbon heat in Europe has become focused on a narrow range of technological options and has largely neglected hydrogen and fuel cell technologies, despite these receiving strong support towards commercialisation in Asia. This review examines the potential benefits of these technologies across different markets, particularly the current state of development and performance of fuel cell micro-CHP. Fuel cells offer some important benefits over other low-carbon heating technologies, and steady cost reductions through innovation are bringing fuel cells close to commercialisation in several countries. Moreover, fuel cells offer wider energy system benefits for high-latitude countries with peak electricity demands in winter. Hydrogen is a zero-carbon alternative to natural gas, which could be particularly valuable for those countries with extensive natural gas distribution networks, but many national energy system models examine neither hydrogen nor fuel cells for heating. There is a need to include hydrogen and fuel cell heating technologies in future scenario analyses, and for policymakers to take into account the full value of the potential contribution of hydrogen and fuel cells to low-carbon energy systems
Predicting FVIII Activity in Patients Who Use Recombinant FVIII Fc Fusion Protein for Prophylaxis and Treatment of Bleeding Episodes
High frequency diffraction of an electromagnetic plane wave by an imperfectly conducting rectangular cylinder
Copyright @ 2011 IEEEWe shall consider the the problem of determining the scattered far wave field produced when a plane E-polarized wave is incident on an imperfectly conducting rectangular cylinder. By using the the uniform asymptotic solution for the problem of the diffraction of a plane wave by a right-angled impedance wedge, in conjunction with Keller's method, the a high frequency far field solution to the problem is given
Modeling the optical constants of AlxGa1-xAs alloys
Extension of Adachi's model with a Gaussian-like broadening function instead of a Lorentzian one is used to model the optical dielectric function of the alloy AlxGa1-xAs. Gaussian-like broadening is accomplished by replacing the damping constant in the Lorentzian line shape with a frequency dependent expression. In such a manner, the comparative simplicity of analytic formulae of the model is preserved, while the accuracy becomes comparable to more intricate models, and/or models with a significantly greater number of parameters. The employed model describes accurately the optical dielectric function in the spectral range from 1.5 to 6.0 eV in the entire alloy composition range. Relative rms error obtained for the refractive index is below 2.2% for all compositionspublished_or_final_versio
Keratin 6a marks mammary bipotential progenitor cells that can give rise to a unique tumor model resembling human normal-like breast cancer.
Progenitor cells are considered an important cell of origin of human malignancies. However, there has not been any single gene that can define mammary bipotential progenitor cells, and as such it has not been possible to use genetic methods to introduce oncogenic alterations into these cells in vivo to study tumorigenesis from them. Keratin 6a is expressed in a subset of mammary luminal epithelial cells and body cells of terminal end buds. By generating transgenic mice using the Keratin 6a (K6a) gene promoter to express tumor virus A (tva), which encodes the receptor for avian leukosis virus subgroup A (ALV/A), we provide direct evidence that K6a(+) cells are bipotential progenitor cells, and the first demonstration of a non-basal location for some biopotential progenitor cells. These K6a(+) cells were readily induced to form mammary tumors by intraductal injection of RCAS (an ALV/A-derived vector) carrying the gene encoding the polyoma middle T antigen. Tumors in this K6a-tva line were papillary and resembled the normal breast-like subtype of human breast cancer. This is the first model of this subtype of human tumors and thus may be useful for preclinical testing of targeted therapy for patients with normal-like breast cancer. These observations also provide direct in vivo evidence for the hypothesis that the cell of origin affects mammary tumor phenotypes
Dimensionally and compositionally controlled growth of calcium phosphate nanowires for bone tissue regeneration
Nanostructured biomaterials with controlled morphology and composition are of high interest for bone tissue regeneration. As resorbable and biocompatible materials for bone tissue engineering, calcium phosphate nanowires and nanoneedles with different aspect ratios and compositions have been first synthesized without the use of any toxic surfactants via an energy efficient microwave assisted process. Correlation between solvent composition, mixing methodology and reagent stoichiometric ratios was investigated with the aim of producing orientated growth and varied biphasic composition, resulting in dimensionally controlled growth of materials containing varying hydroxyapatite (HA)/monetite quantities. It was observed that the HA/monetite content and dimensionality could be manipulated by changing the initial ethanol (EtOH) volume in the H2O/EtOH solvent mixture. Three dimensional particles with minute amounts of HA were produced when a H2O/EtOH volumetric ratio of 20/80 was used. Conversely, high aspect ratio (ca. 54) nanowires containing ca. 38 wt% HA were obtained with a 60/40 H2O/EtOH volumetric ratio. Importantly, the quantity of HA in the high aspect ratio nanowires/needles was controlled by varying the stoichiometric ratio of the reactants, demonstrating that one-dimensional materials with close to 100% HA can be achieved when the Ca/P ratio is increased to 1.67. Additionally, significant correlation between the extent of orientated growth of the materials and the point of EtOH addition during the mixing method was observed. The findings highlight that solvent composition, reactant stoichiometric ratio and mixing procedure can be used in tandem to tailor the morphology and composition of calcium phosphate materials, which are of very high importance in developing excellent materials suitable for bone tissue regeneration
Estimation of Spectroscopic Uncertainty and Correlation in Terahertz Time Domain Spectroscopy
We present a method of calculating the measurement variance-covariance matrix of a spectroscopic sample’s complex refractive index from time-domain statistics in order to estimate uncertainty of a measurement. We compare this method to a numerical analysis and previously derived methodology, and show that our time-based estimate is both accurate and adaptable to complex extraction models
Multilayer Extraction of Complex Refractive Index in Broadband Transmission Terahertz Time-Domain Spectroscopy
In terahertz spectroscopy, multi-layered samples often need to be measured, for instance in a liquid flow cell, and this complicates the extraction of material parameters. We present a spectroscopic parameter extraction algorithm for multilayer samples that can also be used to extract the thickness of an unknown sample laye
G protein-coupled receptor GPR37-like 1 regulates adult oligodendrocyte generation
Oligodendrocytes (OLs) continue to be generated from OL precursors (OPs) in the adult mammalian brain. Adult-born OLs are believed to contribute to neural plasticity, learning and memory through a process of “adaptive myelination”, but how adult OL generation and adaptive myelination are regulated remains unclear. Here, we report that the glia-specific G protein-coupled receptor 37-like 1 (GPR37L1) is expressed in subsets of OPs and newly-formed immature OLs in adult mouse brain. We found that OP proliferation and differentiation are inhibited in the corpus callosum of adult Gpr37l1 knockout mice, leading to a reduction in the number of adult-born OLs. Our data raise the possibility that GPR37L1 is mechanistically involved in adult OL generation and adaptive myelination, and suggest that GPR37L1 might be a useful functional marker of OPs that are committed to OL differentiation
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