928 research outputs found
Manipulating expectation of pain inhibition elicits differential effects on cortical and spinal level nociceptive processing
Antibacterial nanocomposites based on Ag NPs and HMDSO deposited by atmospheric pressure plasma
The development of new multifunctional coatings with antimicrobial properties has a special interest in several applications for pharmaceutical and medical products. This work reports on the deposition of antimicrobial coatings based on silver nanoparticles (Ag NPs) embedded in an organosilicon film onto woven and nonwoven textiles. The Ag nanoparticles admixed with hexamethyldisiloxane (HMDSO) vapours are introduced by means of an atomizer system in the remote discharge of an atmospheric pressure plasma source operating in argon. The chemical properties and the surface morphology of the coatings with antimicrobial potential are discussed.This work was performed within the M-ERA-NET
project PlasmaTex, contract 31/2016/ UEFISCDI. The
financial support from the Ministry of Research and
Innovation under the Nucleus contract 4N/2016 is
gratefully acknowledged.info:eu-repo/semantics/publishedVersio
Freshwater Sponges Have Functional, Sealing Epithelia with High Transepithelial Resistance and Negative Transepithelial Potential
Epithelial tissue â the sealed and polarized layer of cells that regulates transport of ions and solutes between the environment and the internal milieu â is a defining characteristic of the Eumetazoa. Sponges, the most ancient metazoan phylum [1], [2], are generally believed to lack true epithelia [3], [4], [5], but their ability to occlude passage of ions has never been tested. Here we show that freshwater sponges (Demospongiae, Haplosclerida) have functional epithelia with high transepithelial electrical resistance (TER), a transepithelial potential (TEP), and low permeability to small-molecule diffusion. Curiously, the Amphimedon queenslandica sponge genome lacks the classical occluding genes [5] considered necessary to regulate sealing and control of ion transport. The fact that freshwater sponge epithelia can seal suggests that either occluding molecules have been lost in some sponge lineages, or demosponges use novel molecular complexes for epithelial occlusion; if the latter, it raises the possibility that mechanisms for occlusion used by sponges may exist in other metazoa. Importantly, our results imply that functional epithelia evolved either several times, or once, in the ancestor of the Metazoa
Trade unions, civil society organisations and health reforms
This article provides an analysis of resistance to neoliberalism and commodification in the public healthcare sector as seen from a trade union perspective. It uses recent research on social-movement unionism and new labour internationalism to structure a series of case studies examining resistance to different dimensions of healthcare commodification in four countries. The range of alliances trade unions are making do not fit tidily into one model, but give insights into the movement elements of trade unionism. This dimension must be strengthened, but can also be in tension with collective bargaining and other institutional processes. How to constantly reconcile these different positions is the future challenge facing trade unions
Antimicrobial efficacy of low concentration PVP-silver nanoparticles deposited on DBD plasma-treated polyamide 6,6 fabric
In this study, a low concentration (10 ÎŒg·mLâ1) of poly(N-vinylpyrrolidone) (PVP)-coated silver nanoparticles (AgNPs) were deposited by spray and exhaustion (30, 70 and 100 âŠC) methods onto untreated and dielectric barrier discharge (DBD) plasma-treated polyamide 6,6 (PA66) fabric. DBD plasma-treated samples showed higher AgNP deposition than untreated ones for all methods. After five washing cycles, only DBD plasma-treated samples displayed AgNPs on the fabric surface. The best-performing method was exhaustion at 30 âŠC, which exhibited less agglomeration and the best antibacterial efficacy against S. aureus (4 log reduction). For E. coli, the antimicrobial effect showed good results in all the exhaustion samples (5 log reduction). Considering the spray method, only the DBD plasma-treated samples showed some bacteriostatic activity for both strains, but the AgNP concentration was not enough to have a bactericidal effect. Our results suggest DBD plasma may be a low cost and chemical-free method for the preparation of antibacterial textiles, allowing for the immobilization of a very lowâbut effectiveâconcentration of AgNPs.This work was funded by European Regional Development funds (FEDER) through the Competitiveness and Internationalization Operational Program (POCI) â COMPETE and by National Funds through FundaçaÌo para a CieÌncia e Tecnologia (FCT)âunder the project POCI-01-0145-FEDER-007136 and UID/CTM/00264/2019. Isabel Ribeiro (SFRH/BD/137668/2018) acknowledges FCT, Portugal, for its doctoral grant financial support. A. Zille also acknowledges financial support of the FCT through an Investigator FCT Research contract (IF/00071/2015) and the project PTDC/CTM-TEX/28295/2017 financed by FCT, FEDER and POCI in the frame of the Portugal 2020 program
Psychopolitics: Peter Sedgwickâs legacy for mental health movements
This paper re-considers the relevance of Peter Sedgwick's Psychopolitics (1982) for a politics of mental health. Psychopolitics offered an indictment of âanti-psychiatryâ the failure of which, Sedgwick argued, lay in its deconstruction of the category of âmental illnessâ, a gesture that resulted in a politics of nihilism. âThe radical who is only a radical nihilistâ, Sedgwick observed, âis for all practical purposes the most adamant of conservativesâ. Sedgwick argued, rather, that the concept of âmental illnessâ could be a truly critical concept if it was deployed âto make demands upon the health service facilities of the society in which we liveâ. The paper contextualizes Psychopolitics within the âcrisis tendenciesâ of its time, surveying the shifting welfare landscape of the subsequent 25 years alongside Sedgwick's continuing relevance. It considers the dilemma that the discourse of âmental illnessâ â Sedgwick's critical concept â has fallen out of favour with radical mental health movements yet remains paradigmatic within psychiatry itself. Finally, the paper endorses a contemporary perspective that, while necessarily updating Psychopolitics, remains nonetheless âSedgwickianâ
Discourse or dialogue? Habermas, the Bakhtin Circle, and the question of concrete utterances
This is the author's accepted manuscript. The final publication is available at Springer via the link below.This article argues that the Bakhtin Circle presents a more realistic theory of concrete dialogue than the theory of discourse elaborated by Habermas. The Bakhtin Circle places speech within the âconcrete whole utteranceâ and by this phrase they mean that the study of everyday language should be analyzed through the mediations of historical social systems such as capitalism. These mediations are also characterized by a determinate set of contradictionsâthe capital-labor contradiction in capitalism, for exampleâthat are reproduced in unique ways in more concrete forms of life (the state, education, religion, culture, and so on). Utterances always dialectically refract these processes and as such are internal concrete moments, or concrete social forms, of them. Moreover, new and unrepeatable dialogic events arise in these concrete social forms in order to overcome and understand the constant dialectical flux of social life. But this theory of dialogue is different from that expounded by Habermas, who tends to explore speech acts by reproducing a dualism between repeatable and universal âabstractâ discursive processes (commonly known as the ideal speech situation) and empirical uses of discourse. These critical points against Habermas are developed by focusing on six main areas: sentences and utterances; the lifeworld and background language; active versus passive understandings of language; validity claims; obligation and relevance in language; and dialectical universalism
Population policies and education: exploring the contradictions of neo-liberal globalisation
The world is increasingly characterised by profound income, health and social inequalities (Appadurai, 2000). In recent decades development initiatives aimed at reducing these inequalities have been situated in a context of increasing globalisation with a dominant neo-liberal economic orthodoxy. This paper argues that neo-liberal globalisation contains inherent contradictions regarding choice and uniformity. This is illustrated in this paper through an exploration of the impact of neo-liberal globalisation on population policies and programmes. The dominant neo-liberal economic ideology that has influenced development over the last few decades has often led to alternative global visions being overlooked. Many current population and development debates are characterised by polarised arguments with strongly opposing aims and views. This raises the challenge of finding alternatives situated in more middle ground that both identify and promote the socially positive elements of neo-liberalism and state intervention, but also to limit their worst excesses within the population field and more broadly. This paper concludes with a discussion outling the positive nature of middle ground and other possible alternatives
Study on COgnition and Prognosis in the Elderly (SCOPE): baseline characteristics
Blood Press. 2000;9(2-3):146-51.
Study on COgnition and Prognosis in the Elderly (SCOPE): baseline characteristics.
Hansson L, Lithell H, Skoog I, Baro F, BĂĄnki CM, Breteler M, Castaigne A, Correia M, Degaute JP, Elmfeldt D, Engedal K, Farsang C, Ferro J, Hachinski V, Hofman A, James OF, Krisin E, Leeman M, de Leeuw PW, Leys D, Lobo A, Nordby G, Olofsson B, Opolski G, Prince M, Reischies FM.
University of Uppsala, Department of Public Health, Clinical Hypertension Research, Sweden.
Abstract
The Study on COgnition and Prognosis in the Elderly (SCOPE) is a multi-centre, prospective, randomized, double-blind, parallel-group study. The primary objective of SCOPE is to assess the effect of the angiotensin II type 1 (AT1) receptor blocker, candesartan cilexetil 8-16 mg once daily, on major cardiovascular events in elderly patients (70-89 years of age) with mild hypertension (DBP 90-99 and/or SBP 160-179 mmHg). The secondary objectives of the study are to test the hypothesis that antihypertensive therapy can prevent cognitive decline (as measured by the Mini Mental State Examination, MMSE) and dementia, and to assess the effect of therapy on total mortality, myocardial infarction (MI), stroke, renal function, and hospitalization. A total of 4964 patients from 15 participating countries were recruited during the randomization phase of SCOPE, exceeding the target population of 4000. The mean age of the patients at enrolment was 76 years, the ratio of male to female patients was approximately 1:2, and 52% of patients were already being treated with an antihypertensive agent at enrolment. The majority of patients (88%) were educated to at least primary school level. At randomization, mean sitting blood pressure values were SBP 166 mmHg and DBP 90 mmHg, and the mean MMSE score was 28. Previous cardiovascular disease in the study population included myocardial infarction (4%), stroke (4%) and atrial fibrillation (4%). Men, more often than women, had a history of previous MI, stroke and atrial fibrillation. A greater percentage of men were smokers (13% vs 6% in women) and had attended university (11% vs 3% of women). Of the randomized patients, 21% were 80 years of age. In this age group smoking was less common (4% vs 10% for 70-79-year-olds) and fewer had attended university (4% vs 7% for 70-79-year-olds). The incidence of MI was similar in both age groups. However, stroke and atrial fibrillation had occurred approximately twice as frequently in the older patients. The patients' mean age at baseline was similar in the participating countries, and most countries showed the approximate 1:2 ratio for male to female patients. There was also little inter-country variation in terms of mean SBP, DBP or MMSE score. However, there was considerable regional variation in the percentage of patients on therapy prior to enrolment.
PMID: 10855739 [PubMed - indexed for MEDLINE
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