Investigating openability of rigid plastic containers with peelable lids : the link between human strength and grip and opening forces

As society ages there is a growing need to understand issues surrounding declining user capabilities. One such area has been accessibility of packaging by older people. To date much of the current research in this area has focused on measuring strength of older people and analysing the force needed to open various pack formats and has largely concentrated on accessibility of jam or sauce jars. However, a survey by 'Yours' magazine indicated that problems with thin film pack forms and peelable packaging was also an issue for older people. Hence the authors undertook a small-scale study to understand the issues surrounding accessing a rigid plastic container with a peelable lid. To that end the authors built a bespoke measuring device to measure container peeling forces, measured finger friction between pack and finger and undertook an observational analysis on 60 users accessing packaging of this type. Results indicated that the force needed to open containers of this type is lower than measured user forces including older people and it is therefore likely that the issues surrounding accessibility of this type of pack format are related to dexterity not strength. However, the authors also showed that this can be affected by context of use in that oily fingers could reduce the friction coefficient between finger and pack such that older people may not have sufficient strength to open packs of this type

Children as engineers: Paired peer mentors in primary schools final report summary July 2015

◾It’s been forecast that a further 100,000 new professionals are needed to fill the skills gap by 2020. It is becoming increasingly important that student engineers gain opportunities to practise their public engagement and education outreach skills to influence public perceptions of engineering, and connect science with society (Research Councils UK, 2010; National Coordinating Centre for Public Engagement, 2010).◾Teachers are a key audience with which to engage, as only 5% of primary school teachers have a science related degree (Department for Education, 2013). Although subject knowledge is not seen as essential for effective pedagogy, a lack of confidence and understanding can result in a style of teaching which reduces pupils’ performance, engagement and enjoyment with the subject (Ofsted, 2011).◾In this project, student engineers and pre-service teachers were paired up to mentor each other and enact hands-on challenges designed to demonstrate the Engineering Design Process to primary schoolchildren.◾The project appeared to be successful on all levels for the different participant groups. Quantitatively the student engineers showed an improvement in their perceived level of skills, with a 42% improvement in the proportion who felt they were now ‘fairly well equipped’ to undertake public engagement; over two-thirds (64%) of the engineers gave this rating following the project. Additionally, 70% of the engineers indicated that they thought they are now likely to be ‘more active’ in public engagement. Qualitatively, the student engineers indicated that that they had learnt organisational and communication skills through taking part, and felt that they had passed on some of their science and engineering subject knowledge and enthusiasm to the teachers and children.◾The paired peer partnership model was also positively reviewed by the pre-service teachers. Quantitative data indicated that the teachers showed significant increases in their science and engineering subject knowledge confidence levels as well as in teaching self-efficacy for both subjects. 80% of the pre-service teachers who participated stated that they would undertake similar work with children in the future. Many teachers asserted that the ‘expert’ knowledge gained had also benefitted and influenced the pupils in their class.◾Children who took part in the project had increased positive attitudes to the subjects of science and engineering in quantitative assessments. The project improved children’s knowledge of what an engineer does and their attitudes towards the profession through greater information about engineering and the experience of real life role models. The data also indicated a slight positive shift in children’s attitudes to science and engineering career aspirations along with gender and engineering identities

Genetic, structural, and molecular insights into the function of ras of complex proteins domains

Ras of complex proteins (ROC) domains were identified in 2003 as GTP binding modules in large multidomain proteins from Dictyostelium discoideum. Research into the function of these domains exploded with their identification in a number of proteins linked to human disease, including leucine-rich repeat kinase 2 (LRRK2) and death-associated protein kinase 1 (DAPK1) in Parkinson’s disease and cancer, respectively. This surge in research has resulted in a growing body of data revealing the role that ROC domains play in regulating protein function and signaling pathways. In this review, recent advances in the structural informa- tion available for proteins containing ROC domains, along with insights into enzymatic function and the integration of ROC domains as molecular switches in a cellular and organismal context, are explored

Draft Genome of Thermanaerothrix daxensis GNS-1, a Thermophilic Facultative Anaerobe from the Chloroflexi Class Anaerolineae

We present the draft genome of Thermanaerothrix daxensis GNS-1, a thermophilic member of the Chloroflexi phylum. This organism was initially characterized as a nonmotile, strictly anaerobic fermenter; however, genome analysis demonstrates that it encodes genes for a flagellum and multiple pathways for aerobic and anaerobic respiration

Draft Genome Sequence of Ardenticatena maritime 110S, a Thermophilic Nitrate- and Iron-Reducing Member of the Chloroflexi Class Ardenticatenia

We report here the draft genome sequence of Ardenticatena maritima 110S, the first sequenced member of class Ardenticatenia of the phylum Chloroflexi. This thermophilic organism is capable of a range of physiologies, including aerobic respiration and iron reduction. It also encodes a complete denitrification pathway with a novel nitric oxide reductase

Draft Genome Sequence of Ornatilinea apprima P3M-1, an Anaerobic Member of the Chloroflexi Class Anaerolineae

We report the draft genome sequence of Ornatilinea apprima P3M-1, a strictly anaerobic member of the Chloroflexi class Anaerolineae. This genome provides insight into the diversity of metabolism within the Anaerolineae, and the evolution of respiration within the Chloroflexi

Draft Genome Sequence of Herpetosiphon geysericola GC-42, a Nonphototrophic Member of the Chloroflexi Class Chloroflexia

We report here the draft genome sequence of Herpetosiphon geysericola GC-42, a predatory nonphototrophic member of the class Chloroflexia in the phylum Chloroflexi. This genome provides insight into the evolution of phototrophy and aerobic respiration within the Chloroflexi

Draft Genome Sequence of Levilinea saccharolytica KIBI-1, a Member of the Chloroflexi Class Anaerolineae

We report the draft genome sequence of Levilinea saccharolytica KIBI-1, a facultative anaerobic member of the Chloroflexi class Anaerolineae. While L. saccharolytica was characterized as an obligate anaerobe, genome analysis provides evidence for the presence of both aerobic respiration and partial denitrification pathways

Pre-Altitude Serum Ferritin Levels and Daily Oral Iron Supplement Dose Mediate Iron Parameter and Hemoglobin Mass Responses to Altitude Exposure

Purpose : To investigate the influence of daily oral iron supplementation on changes in hemoglobin mass (Hbmass) and iron parameters after 2–4 weeks of moderate altitude exposure.Methods :Hematological data collected from 178 athletes (98 males, 80 females) exposed to moderate altitude (1,350–3,000 m) were analysed using linear regression to determine how altitude exposure combined with oral iron supplementation influenced Hbmass, total iron incorporation (TII) and blood iron parameters [ferritin and transferrin saturation (TSAT)]. Results :Altitude exposure (mean ± s: 21 ± 3 days) increased Hbmass by 1.1% [-0.4, 2.6], 3.3% [1.7, 4.8], and 4.0% [2.0, 6.1] from pre-altitude levels in athletes who ingested nil, 105 mg and 210 mg respectively, of oral iron supplement daily. Serum ferritin levels decreased by -33.2% [-46.9, -15.9] and 13.8% [-32.2, 9.7] from pre-altitude levels in athletes who supplemented with nil and 105 mg of oral iron supplement daily, but increased by 36.8% [1.3, 84.8] in athletes supplemented with 210 mg of oral iron daily. Finally, athletes who ingested either 105 mg or 210 mg of oral iron supplement daily had a greater TII compared with non-supplemented athletes (0 versus 105 mg: effect size (d) = -1.88 [-2.56, -1.17]; 0 versus 210 mg: effect size (d) = -2.87 [-3.88, -1.66]). Conclusion :Oral iron supplementation during 2–4 weeks of moderate altitude exposure may enhance Hbmass production and assist the maintenance of iron balance in some athletes with low pre-altitude iron stores