Youth Residing in Out-of-Home Placements: Examination of Behavior and Academic Achievement

A data set from the National Survey of Child and Adolescent Well-Being II was analyzed to determine if significant relationships existed between participants’ internalizing and externalizing scores on the Child Behavior Checklist (CBCL) and their (a) scores on assessments of academic achievement and (b) behavior problems leading to suspension or expulsion. Results indicated that participants’ scores on the CBCL were not predictive of their academic achievement but were predictive of their numbers of behavior problems leading to suspension or expulsion

Considerations in Promoting Parent and Family Involvement

It has been recognized for decades that parent and family (PF) involvement is a vital component of students\u27 educational experiences. Moreover, PF involvement is identified as an important protective factor for students. Thus, school administrators and educators understanding and encouraging positive relationships between families and schools may be one way to promote academic, social, and emotional success for youth throughout their lives. The purpose of this paper is to examine the literature on PF involvement and delineate a proposed model of PF involvement to foster resilience in children and youth

Educational Experiences of Youth with And/or At-risk for Emotional and Behavioral Disorders Residing in Foster Care Settings

Research examining the academic experiences of youth with emotional and behavioral disorders (EBD) residing in foster care (FC) is scarce. Research is warranted to understand the academic strengths, weaknesses, and school disciplinary experiences of youth with EBD residing in FC. Data from the National Survey of Child and Adolescent Well-being II (NSCAW II) included data on eight participants classified as EBD. Having a limited number of participants classified as EBD in the data set, I used participants’ scores on the Child Behavior Checklist (CBCL) to classify participants who may be at-risk for EBD. Analyses were conducted to determine if significant relationships existed between participants’ internalizing and externalizing scores on the CBCL and their (a) scores on assessments of academic achievement and (b) behavior problems leading to suspension or expulsion. Results indicated that participants’ scores on the CBCL were not predictive of their academic achievement or of their numbers of behavior problems leading to suspension or expulsion

Lung cancer:intragenic ERBB2 kinase mutations in tumours

The protein-kinase family is the most frequently mutated gene family found in human cancer and faulty kinase enzymes are being investigated as promising targets for the design of antitumour therapies. We have sequenced the gene encoding the transmembrane protein tyrosine kinase ERBB2 (also known as HER2 or Neu) from 120 primary lung tumours and identified 4% that have mutations within the kinase domain; in the adenocarcinoma subtype of lung cancer, 10% of cases had mutations. ERBB2 inhibitors, which have so far proved to be ineffective in treating lung cancer, should now be clinically re-evaluated in the specific subset of patients with lung cancer whose tumours carry ERBB2 mutations

Genomic architecture of autism from comprehensive whole-genome sequence annotation

Fully understanding autism spectrum disorder (ASD) genetics requires whole-genome sequencing (WGS). We present the latest release of the Autism Speaks MSSNG resource, which includes WGS data from 5,100 individuals with ASD and 6,212 non-ASD parents and siblings (total n = 11,312). Examining a wide variety of genetic variants in MSSNG and the Simons Simplex Collection (SSC; n = 9,205), we identified ASD-associated rare variants in 718/5,100 individuals with ASD from MSSNG (14.1%) and 350/2,419 from SSC (14.5%). Considering genomic architecture, 52% were nuclear sequence-level variants, 46% were nuclear structural variants (including copy-number variants, inversions, large insertions, uniparental isodisomies, and tandem repeat expansions), and 2% were mitochondrial variants. Our study provides a guidebook for exploring genotype-phenotype correlations in families who carry ASD-associated rare variants and serves as an entry point to the expanded studies required to dissect the etiology in the ∼85% of the ASD population that remain idiopathic. [Display omitted] •New MSSNG release contains WGS from 11,312 individuals from families with ASD•Extensive variant data available, including SNVs/indels, SVs, tandem repeats, and PRS•Annotation reveals 134 ASD-associated genes, plus SVs not detectable without WGS•Rare, dominant variation has a prominent role in multiplex ASD The latest release of the Autism Speaks MSSNG resource provides an expanded sample size and facilitates the comprehensive examination of the roles of many types of genetic variation in autism spectrum disorder