Singularly Perturbed Monotone Systems and an Application to Double Phosphorylation Cycles

The theory of monotone dynamical systems has been found very useful in the modeling of some gene, protein, and signaling networks. In monotone systems, every net feedback loop is positive. On the other hand, negative feedback loops are important features of many systems, since they are required for adaptation and precision. This paper shows that, provided that these negative loops act at a comparatively fast time scale, the main dynamical property of (strongly) monotone systems, convergence to steady states, is still valid. An application is worked out to a double-phosphorylation ``futile cycle'' motif which plays a central role in eukaryotic cell signaling.Comment: 21 pages, 3 figures, corrected typos, references remove

Chronic lymphocytic leukaemia Australasian consensus practice statement

Chronic lymphocytic leukaemia (CLL) is the most common haematological malignancy in Australia and New Zealand (ANZ). Considerable changes to diagnostic and management algorithms have occurred within the last decade. The availability of next-generation sequencing and measurable residual disease assessment by flow cytometry allow for advanced prognostication and response assessments. Novel therapies, including inhibitors of Bruton's tyrosine kinase (BTKi) and B-cell lymphoma 2 (BCL2) inhibitors, have transformed the treatment landscape for both treatment-naïve and relapsed/refractory disease, particularly for patients with high-risk genetic aberrations. Recommendations regarding appropriate supportive management continue to evolve, and special considerations are required for patients with CLL with respect to the global SARS-CoV-2 pandemic. The unique funding and treatment environments in Australasia highlight the need for specific local guidance with respect to the investigation and management of CLL. This consensus practice statement was developed by a broadly representative group of ANZ experts in CLL with endorsement by peak haematology bodies, with a view to providing this standardised guidance

Evaluation of soft tissue profile following intraoral ramus osteotomy in Chinese adults with mandibular prognathism.

The International journal of adult orthodontics and orthognathic surgery53189-19

Command and Data Handling in your Palm

The shift in emphasis to smaller, better, and cheaper spacecraft, resulting from the NASA New Millennium Program (NMP) and similar initiatives in DoD-sponsored programs, demands highly innovative designs that standard electronic packaging cannot meet. Current technology primarily uses conventional packaging with surface mounted or through hole components. This approach increases the board size and the overall system weight owing to the larger sizes of the board and the components mounted on it. Chip-on-Board (COB) technology, where active dice are directly mounted onto a substrate without the need for an intermediate package, provides the basic vehicle to miniaturize electronic hardware. This technology allows the use of both bare dice and packaged components when parts availability, cost and schedule become major factors influencing design decisions. In a cooperative effort between The Johns Hopkins University Applied Physics Laboratory (JHU/APL) Space Department and the Goddard Space Flight Center Code 310 Assurance Technologies Division, a family of miniaturized, stackable electronics modules is under development. These modules can implement anything from a standalone Instrument Processor, to a Command & Data Handling system, or the entire electronics needed by a spacecraft. The small size of these modules makes them ideal for use in small satellites