Transient domain walls and lepton asymmetry in the Left-Right symmetric model

It is shown that the dynamics of domain walls in Left-Right symmetric models, separating respective regions of unbroken SU(2)_L and SU(2)_R in the early universe, can give rise to baryogenesis via leptogenesis. Neutrinos have a spatially varying complex mass matrix due to CP-violating scalar condensates in the domain wall. The motion of the wall through the plasma generates a flux of lepton number across the wall which is converted to a lepton asymmetry by helicity-flipping scatterings. Subsequent processing of the lepton excess by sphalerons results in the observed baryon asymmetry, for a range of parameters in Left-Right symmetric models.Comment: v2 version accepted for publication in Phys. Rev. D. Discussion in Introduction and Conclusion sharpened. Equation (12) corrected. 16 pages, 3 figure files, RevTeX4 styl

Decision analytic approach to severe head injury management.

Proceedings / AMIA . Annual Symposium. AMIA Symposium271-27

The Patient Activation through Community Empowerment/Engagement for Diabetes Management (PACE-D) protocol: A non-randomised controlled trial of personalised care and support planning for persons living with diabetes

10.1186/s12875-020-01173-2BMC Family Practice21111

Effective Antimicrobial StewaRdship StrategIES (ARIES): Cluster randomized trial of computerized decision support system and prospective review and feedback

10.1093/ofid/ofaa254Open Forum Infectious Diseases77ofaa25

Repurposed JAK1/JAK2 inhibitor reverses established autoimmune insulitis in NOD mice

Recent advances in immunotherapeutics have not yet changed the routine management of autoimmune type 1 diabetes. There is an opportunity to repurpose therapeutics used to treat other diseases to treat type 1 diabetes, especially when there is evidence for overlapping mechanisms. Janus kinase (JAK) 1/JAK2 inhibitors are in development or clinical use for indications including rheumatoid arthritis. There is good evidence for activation of the JAK1/JAK2 and signal transducer and activator of transcription (STAT) 1 pathway in human type 1 diabetes and in mouse models, especially in β-cells. We tested the hypothesis that using these drugs to block the JAK-STAT pathway would prevent autoimmune diabetes. The JAK1/JAK2 inhibitor AZD1480 blocked the effect of cytokines on mouse and human β-cells by inhibiting MHC class I upregulation. This prevented the direct interaction between CD8+ T cells and β-cells, and reduced immune cell infiltration into islets. NOD mice treated with AZD1480 were protected from autoimmune diabetes, and diabetes was reversed in newly diagnosed NOD mice. This provides mechanistic groundwork for repurposing clinically approved JAK1/JAK2 inhibitors for type 1 diabetes.</jats:p

Tetralogia de Fallot em cão Tetralogy of Fallot in dogs

A Tetralogia de Fallot é uma moléstia cardíaca congênita caracterizada pela presença de hipoxemia provocada principalmente pela estenose pulmonar e defeito septal interventricular, exteriorizada pelo animal com o quadro de cianose. Atualmente, tem-se vários métodos de diagnóstico de grande precisão, na determinação de tal afecção. Existem vários tratamentos da Tetralogia de Fallot, desde medicamentoso até a sua correção cirúrgica definitiva, com o reparo dos defeitos cardíacos. Aquele que vem sendo mais utilizado é o tratamento cirúrgico paliativo, com a criação de um desvio sistêmico-pulmonar, utilizando-se a técnica de Blalock-Taussig, que cria uma comunicação entre a aorta e a artéria pulmonar com a artéria subclávia esquerda.<br>Tetralogy of Fallot is a congenital cardiac disease characterized by the presence of hypoxemia because of the pulmonary stenosis and the ventricular septal defect. The symptom in the animal is cianosis. Actually, there are many diagnostic methods of this affection. There are many treatments for Tetralogy of Fallot, such as the medicamentosus treatment and the definitive surgical correction, reparing the cardiac defects. The most used is the palliative surgical treatment, creating systemic-pulmonar shunt. The most famous surgical method is the Blalock-Taussig surgery, when the surgeon creates a communication between the aorta and pulmonary artery, using the left subclavian artery

Members in Tourism Settings – their motivations, behaviours and roles

Membership programs are widely-used marketing tools. Many customers belong to a number of different membership programs across a variety of organizations and contexts. Memberships are based on the idea of mutual benefits of a relationship. Memberships in general offer tangible and intangible benefits such as free admission, discounts, special offers or access to special services, and a sense of belonging and identity. General organizational benefits of memberships besides customers are funding, fee revenue, legitimacy, and various kinds of member support. Memberships are used as competitive relationship marketing tools to retain customers, build relationships and encourage member participation. Many memberships have developed from merely being reward programs into an attempt to create emotional bonds based on calculative and affective commitment. Research into memberships is an emergent multidisciplinary field of interest for practitioners and scholars representing different disciplines. This thesis is delimited to study members and memberships at nonprofit organizations within tourism settings from a relationship marketing perspective. The aim is to get insight into why individuals choose to become members, why they stay on as members, and how members interact and use their memberships. The overall objective is therefore to explore motivations related to memberships and how this is reflected in different member behaviours and member roles within tourism settings. Throughout this thesis a mixed-method research approach was applied combining qualitative and quantitative research to explore the membership phenomenon. This thesis is comprised of four studies based on data from an explorative pre-study (12 respondents), a questionnaire survey (755 respondents), and a Nordic cross-case study (37 respondents). Findings showed member motivations, behaviours and roles within the tourism system. Member motivations were identified as altruistic (doing good for others), self-interest (doing good for yourself) and social (doing good with others). Findings further showed member interactions with other members (M2M), customers/visitors (M2C) and supported organizations (M2B). Member behaviours found were: returning (retention); supporting, visiting, using member information (participation); marketing, spreading WOM and recruiting new members; and volunteering (co-creation). Furthermore, significant relations were found between motivational dimensions, behaviours and member demographics (age, gender, and distance). Members performed multiple overlapping roles from being supporters and visitors to front-line co-creators