A Genetic Locus Regulates the Expression of Tissue-Specific mRNAs from Multiple Transcription Units

129 GIX- mice, unlike animals of the congeneic partner strain GIX+, do not express significant amounts of the retroviral antigens gp70 and p30. Evidence is presented indicating that the GIX phenotype is specified by a distinct regulatory gene acting on multiple transcription units to control the levels of accumulation of specific mRNA species. The steady-state levels of retroviral-homologous mRNA from the tissues of GIX+ and GIX- mice were examined by blot hybridization using as probes DNA fragments from cloned murine leukemia viruses. RNA potentially encoding viral antigens was reduced or absent in GIX- mice, even though no differences in integrated viral genomes were detected between these congeneic strains by DNA blotting. Tissue-specific patterns of accumulation of these RNA species were detected in brain, epididymis, liver, spleen, and thymus, and several distinct RNA species were found to be coordinately regulated with the GIX phenotype. Measurements of RNA synthesis suggest a major role for transcriptional control in the regulation of some retroviral messages

Electrical manipulation of an electronic two-state system in Ge/Si quantum dots

We calculate that the electron states of strained self-assembled Ge/Si quantum dots provide a convenient two-state system for electrical control. An electronic state localized at the apex of the quantum dot is nearly degenerate with a state localized at the base of the quantum dot. Small electric fields shift the electronic ground state from apex-localized to base-localized, which permits sensitive tuning of the electronic, optical and magnetic properties of the dot. As one example, we describe how spin-spin coupling between two Ge/Si dots can be controlled very sensitively by shifting the individual dot's electronic ground state between apex and base

The steady state in noncollinear magnetic multilayers

There are at least two different putative steady state solutions for current across noncollinear magnetic multilayers; one has a discontinuity in the spin current at the interface the other is continuous. We compare the resistance of the two and find the solution with the continuous spin currents is lower. By using the entropic principle we can state that this solution is a better estimate of the resistance for a noncollinear magneticComment: 14 pages, 4 figures,Submitted to Physical Review

Interdisciplinary study of atmospheric processes and constituents of the mid-Atlantic coastal region.

Past research projects for the year 1974-1975 are listed along with future research programs in the area of air pollution control, remote sensor analysis of smoke plumes, the biosphere component, and field experiments. A detailed budget analysis is presented. Attachments are included on the following topics: mapping forest vegetation with ERTS-1 MSS data and automatic data processing techniques, and use of LARS system for the quantitative determination of smoke plume lateral diffusion coefficients from ERTS images of Virginia

Symmetron Cosmology

The symmetron is a scalar field associated with the dark sector whose coupling to matter depends on the ambient matter density. The symmetron is decoupled and screened in regions of high density, thereby satisfying local constraints from tests of gravity, but couples with gravitational strength in regions of low density, such as the cosmos. In this paper we derive the cosmological expansion history in the presence of a symmetron field, tracking the evolution through the inflationary, radiation- and matter-dominated epochs, using a combination of analytical approximations and numerical integration. For a broad range of initial conditions at the onset of inflation, the scalar field reaches its symmetry-breaking vacuum by the present epoch, as assumed in the local analysis of spherically-symmetric solutions and tests of gravity. For the simplest form of the potential, the energy scale is too small for the symmetron to act as dark energy, hence we must add a cosmological constant to drive late-time cosmic acceleration. We briefly discuss a class of generalized, non-renormalizable potentials that can have a greater impact on the late-time cosmology, though cosmic acceleration requires a delicate tuning of parameters in this case.Comment: 42 page

Analytical modeling of circuit aerodynamics in the new NASA Lewis wind tunnel

Rehabilitation and extention of the capability of the altitude wind tunnel (AWT) was analyzed. The analytical modeling program involves the use of advanced axisymmetric and three dimensional viscous analyses to compute the flow through the various AWT components. Results for the analytical modeling of the high speed leg aerodynamics are presented; these include: an evaluation of the flow quality at the entrance to the test section, an investigation of the effects of test section bleed for different model blockages, and an examination of three dimensional effects in the diffuser due to reentry flow and due to the change in cross sectional shape of the exhaust scoop

Different steady states for spin currents in noncollinear multilayers

We find there are at least two different steady states for transport across noncollinear magnetic multilayers. In the conventional one there is a discontinuity in the spin current across the interfaces which has been identified as the source of current induced magnetic reversal; in the one advocated herein the spin torque arises from the spin accumulation transverse to the magnetization of a magnetic layer. These two states have quite different attributes which should be discerned by current experiments.Comment: 8 pages, no figure. Accepted for publication in Journal of Physics: Condensed Matte

Instant restore after a media failure

Media failures usually leave database systems unavailable for several hours until recovery is complete, especially in applications with large devices and high transaction volume. Previous work introduced a technique called single-pass restore, which increases restore bandwidth and thus substantially decreases time to repair. Instant restore goes further as it permits read/write access to any data on a device undergoing restore--even data not yet restored--by restoring individual data segments on demand. Thus, the restore process is guided primarily by the needs of applications, and the observed mean time to repair is effectively reduced from several hours to a few seconds. This paper presents an implementation and evaluation of instant restore. The technique is incrementally implemented on a system starting with the traditional ARIES design for logging and recovery. Experiments show that the transaction latency perceived after a media failure can be cut down to less than a second and that the overhead imposed by the technique on normal processing is minimal. The net effect is that a few "nines" of availability are added to the system using simple and low-overhead software techniques