Apollo experience report: Certification test program

A review of the Apollo spacecraft certification (qualification) test program is presented. The approach to devising the spectrum of dynamic and climatic environments, the formulation of test durations, and the relative significance of the formal certification test program compared with development testing and acceptance testing are reviewed. Management controls for the formulation of test requirements, test techniques, data review, and acceptance of test results are considered. Significant experience gained from the Apollo spacecraft certification test program which may be applicable to future manned spacecraft is presented

Exact renormalization-group analysis of first order phase transitions in clock models

We analyze the exact behavior of the renormalization group flow in one-dimensional clock-models which undergo first order phase transitions by the presence of complex interactions. The flow, defined by decimation, is shown to be single-valued and continuous throughout its domain of definition, which contains the transition points. This fact is in disagreement with a recently proposed scenario for first order phase transitions claiming the existence of discontinuities of the renormalization group. The results are in partial agreement with the standard scenario. However in the vicinity of some fixed points of the critical surface the renormalized measure does not correspond to a renormalized Hamiltonian for some choices of renormalization blocks. These pathologies although similar to Griffiths-Pearce pathologies have a different physical origin: the complex character of the interactions. We elucidate the dynamical reason for such a pathological behavior: entire regions of coupling constants blow up under the renormalization group transformation. The flows provide non-perturbative patterns for the renormalization group behavior of electric conductivities in the quantum Hall effect.Comment: 13 pages + 3 ps figures not included, TeX, DFTUZ 91.3

The structure of lightning flashes HF-UHF: 12 September 1975, Atlanta, Georgia

Simultaneous measurement of sferics at 3, 30, 139, and 295 MHz were made during thunderstorms. Wideband electronics and an analogue tape recorder continuously recorded the radiation from lightning with about 300 kHz of bandwidth. The data were obtained during the passage of a cold front. Flashing rate, burst rate and the structure of individual flashes were recorded. The record of a typical flash begins with a sudden burst of closely spaced pulses whose temporal structure is typical of the stepped leader, and ends in a large pulse suggestive of a first return stroke. The remainder of the flash consists of a sequence of pulses of varying amplitude separated by quiet periods of the order of milliseconds. The shape of these pulses and the temporal structure suggest that the first few large pulses are return strokes. Other discharges begin with widely spaced discrete pulses and resemble the preceding discharge less the leader and return stroke phase. The radiation exhibits a similar structure, at each of the frequencies monitored

The spectroscopy of dimers

Far infrared and Raman spectra of gaseous dimers calculated for many models and reported as functions of reduced temperature

Polyphasic feedback enables tunable cellular timers

Cellular ‘timers’ provide an important function in living cells [1]. Timers help cells defer their responses to stimuli, often for time intervals extending over multiple cell cycles (Figure 1A, left). For example, mammalian oligodendrocyte precursors typically proliferate for ∼7 divisions before differentiating during neural development [2]. The bacterium Bacillus subtilis can respond to sudden nutrient limitation by transforming into a dormant spore after ∼5 cell cycles [3]. Timers can balance proliferation with differentiation to control the sizes of various cell populations. Some timers appear to operate in a largely cell-autonomous fashion, but the underlying genetic circuit mechanisms that enable this remain poorly understood. Protein dilution poses stringent challenges to timer circuits by continually diluting out timer components in proliferating cells ( Figure 1A, right). Recent work suggests that pulsatile or oscillatory dynamics can facilitate timer functions 3 and 4. Here, we show how polyphasic positive feedback — a pulsed architecture that breaks a feedback signal into temporally distinct phases — counteracts protein dilution to facilitate timer behavior

Regulatory activity revealed by dynamic correlations in gene expression noise

Gene regulatory interactions are context dependent, active in some cellular states but not in others. Stochastic fluctuations, or 'noise', in gene expression propagate through active, but not inactive, regulatory links^(1,2). Thus, correlations in gene expression noise could provide a noninvasive means to probe the activity states of regulatory links. However, global, 'extrinsic', noise sources generate correlations even without direct regulatory links. Here we show that single-cell time-lapse microscopy, by revealing time lags due to regulation, can discriminate between active regulatory connections and extrinsic noise. We demonstrate this principle mathematically, using stochastic modeling, and experimentally, using simple synthetic gene circuits. We then use this approach to analyze dynamic noise correlations in the galactose metabolism genes of Escherichia coli. We find that the CRP-GalS-GalE feed-forward loop is inactive in standard conditions but can become active in a GalR mutant. These results show how noise can help analyze the context dependence of regulatory interactions in endogenous gene circuits

Dynamic instabilities of fracture under biaxial strain using a phase field model

We present a phase field model of the propagation of fracture under plane strain. This model, based on simple physical considerations, is able to accurately reproduce the different behavior of cracks (the principle of local symmetry, the Griffith and Irwin criteria, and mode-I branching). In addition, we test our model against recent experimental findings showing the presence of oscillating cracks under bi-axial load. Our model again reproduces well observed supercritical Hopf bifurcation, and is therefore the first simulation which does so

A Nuclear Physics Program at the ATLAS Experiment at the CERN Large Hadron Collider

The ATLAS collaboration has significant interest in the physics of ultra-relativistic heavy ion collisions. We submitted a Letter of Intent to the United States Department of Energy in March 2002. The following document is a slightly modified version of that LOI. More details are available at: http://atlas.web.cern.ch/Atlas/GROUPS/PHYSICS/SM/ionsComment: Letter of Intent submitted to the United States Department of Energy Nuclear Physics Division in March 2002 (revised version

Functional Roles of Pulsing in Genetic Circuits

A fundamental problem in biology is to understand how genetic circuits implement core cellular functions. Time-lapse microscopy techniques are beginning to provide a direct view of circuit dynamics in individual living cells. Unexpectedly, we are discovering that key transcription and regulatory factors pulse on and off repeatedly, and often stochastically, even when cells are maintained in constant conditions. This type of spontaneous dynamic behavior is pervasive, appearing in diverse cell types from microbes to mammalian cells. Here, we review recent work showing how pulsing is generated and controlled by underlying regulatory circuits and how it provides critical capabilities to cells in stress response, signaling, and development. A major theme is the ability of pulsing to enable time-based regulation analogous to strategies used in engineered systems. Thus, pulsatile dynamics is emerging as a central, and still largely unexplored, layer of temporal organization in the cell