Spitzer Science operations: the good, the bad, and the ugly

We review the Spitzer Space Telescope Science Center operations teams and processes and their interfaces with other Project elements -- what we planned early in the development of the science center, what we had at a launch and what we have now and why. We also explore the checks and balances behind building an organizational structure that supports constructive airing of conflicts and a timely resolution that balances the inputs and provides for very efficient on-orbit operations. For example, what organizational roles are involved in reviewing observing schedules, what constituency do they represent and who has authority to approve or disapprove the schedule

LSST Science Data Quality Analysis Subsystem Design

The Large Synoptic Survey Telescope (LSST) will have a Science Data Quality Analysis (SDQA) subsystem for vetting its unprecedented volume of astronomical image data. The SDQA subsystem inhabits three basic realms: image processing, graphical-user-interface (GUI) tools, and alarms/reporting. During pipeline image processing, SDQA data are computed for the images and astronomical sources extracted from the images, and utilized to grade the images and sources. Alarms are automatically sent, if necessary, to initiate swift response to problems found. Both SDQA data and machine-determined grades are stored in a database. At the end of a data-processing interval, e.g., nightly processing or data-release reprocessing, automatic SDQA reports are generated from SDQA data and grades queried from the database. The SDQA reports summarize the science data quality and provide feedback to telescope, camera, facility, observation-scheduling and data-processing personnel. During operations, GUI tools facilitate visualization of image and SDQA data in a variety of ways that allow a small SDQA-operations team of humans to quickly and easily perform manual SDQA on a substantial fraction of LSST data products, and possibly reassign SDQA grades as a result of the visual inspection

Spitzer Science operations: the good, the bad, and the ugly

We review the Spitzer Space Telescope Science Center operations teams and processes and their interfaces with other Project elements -- what we planned early in the development of the science center, what we had at a launch and what we have now and why. We also explore the checks and balances behind building an organizational structure that supports constructive airing of conflicts and a timely resolution that balances the inputs and provides for very efficient on-orbit operations. For example, what organizational roles are involved in reviewing observing schedules, what constituency do they represent and who has authority to approve or disapprove the schedule

Science data quality assessment for the Large Synoptic Survey Telescope

LSST will have a Science Data Quality Assessment (SDQA) subsystem for the assessment of the data products that will be produced during the course of a 10 yr survey. The LSST will produce unprecedented volumes of astronomical data as it surveys the accessible sky every few nights. The SDQA subsystem will enable comparisons of the science data with expectations from prior experience and models, and with established requirements for the survey. While analogous systems have been built for previous large astronomical surveys, SDQA for LSST must meet a unique combination of challenges. Chief among them will be the extraordinary data rate and volume, which restricts the bulk of the quality computations to the automated processing stages, as revisiting the pixels for a post-facto evaluation is prohibitively expensive. The identification of appropriate scientific metrics is driven by the breadth of the expected science, the scope of the time-domain survey, the need to tap the widest possible pool of scientific expertise, and the historical tendency of new quality metrics to be crafted and refined as experience grows. Prior experience suggests that contemplative, off-line quality analyses are essential to distilling new automated quality metrics, so the SDQA architecture must support integrability with a variety of custom and community-based tools, and be flexible to embrace evolving QA demands. Finally, the time-domain nature of LSST means every exposure may be useful for some scientific purpose, so the model of quality thresholds must be sufficiently rich to reflect the quality demands of diverse science aims

Blood Pressure and Cognitive Decline Over 8 Years in Middle-Aged and Older Black and White Americans

Although the association between high blood pressure (BP), particularly in midlife, and late-life dementia is known, less is known about variations by race and sex. In a prospective national study of 22 164 blacks and whites ≥45 years without baseline cognitive impairment or stroke from the REGARDS cohort study (Reasons for Geographic and Racial Differences in Stroke), enrolled 2003 to 2007 and followed through September 2015, we measured changes in cognition associated with baseline systolic and diastolic BP (SBP and DBP), as well as pulse pressure (PP) and mean arterial pressure, and we tested whether age, race, and sex modified the effects. Outcomes were global cognition (Six-Item Screener; primary outcome), new learning (Word List Learning), verbal memory (Word List Delayed Recall), and executive function (Animal Fluency Test). Median follow-up was 8.1 years. Significantly faster declines in global cognition were associated with higher SBP, lower DBP, and higher PP with increasing age ( P<0.001 for age×SBP×follow-up-time, age×DBP×follow-up-time, and age×PP×follow-up-time interaction). Declines in global cognition were not associated with mean arterial pressure after adjusting for PP. Blacks, compared with whites, had faster declines in global cognition associated with SBP ( P=0.02) and mean arterial pressure ( P=0.04). Men, compared with women, had faster declines in new learning associated with SBP ( P=0.04). BP was not associated with decline of verbal memory and executive function, after controlling for the effect of age on cognitive trajectories. Significantly faster declines in global cognition over 8 years were associated with higher SBP, lower DBP, and higher PP with increasing age. SBP-related cognitive declines were greater in blacks and men

Recognition and management of stroke in young adults and adolescents.

Approximately 15% of all ischemic strokes (IS) occur in young adults and adolescents. To date, only limited prior public health and research efforts have specifically addressed stroke in the young. Early diagnosis remains challenging because of the lack of awareness and the relative infrequency of stroke compared with stroke mimics. Moreover, the causes of IS in the young are heterogeneous and can be relatively uncommon, resulting in uncertainties about diagnostic evaluation and cause-specific management. Emerging data have raised public health concerns about the increasing prevalence of traditional vascular risk factors in young individuals, and their potential role in increasing the risk of IS, stroke recurrence, and poststroke mortality. These issues make it important to formulate and enact strategies to increase both awareness and access to resources for young stroke patients, their caregivers and families, and health care professionals. The American Academy of Neurology recently convened an expert panel to develop a consensus document concerning the recognition, evaluation, and management of IS in young adults and adolescents. The report of the consensus panel is presented herein

The Spitzer Warm Mission Science Prospects

After exhaustion of its cryogen, the Spitzer Space telescope will still have a fully functioning two-channel mid-IR camera that will have sensitivities better than any other ground or space-based telescopes until the launch of JWST. This document provides a description of the expected capabilities of Spitzer during its warm mission phase, and provides brief descriptions of several possible very large science programs that could be conducted. This information is intended to serve as input to a wide ranging discussion of the warm mission science, leading up to the Warm Mission Workshop in June 2007

Caregiving for Older Adults with Obesity in the United States

Peer Reviewedhttps://deepblue.lib.umich.edu/bitstream/2027.42/138397/1/jgs14918_am.pdfhttps://deepblue.lib.umich.edu/bitstream/2027.42/138397/2/jgs14918.pd