Assessing the effectiveness of pen-based input queries

In this poster, we describe an experiment exploring the effectiveness of a pen based text input device for use in query construction. Standard TREC queries were written, recognised, and subsequently retrieved upon. Comparisons between retrieval effectiveness based on the recognised writing and a typed text baseline were made. On average, effectiveness was 75% of the baseline. Other statistics on the quality and nature of recognition are also reported

Which User Interaction for Cross-Language Information Retrieval? Design Issues and Reflections

A novel and complex form of information access is cross-language information retrieval: searching for texts written in foreign languages based on native language queries. Although the underlying technology for achieving such a search is relatively well understood, the appropriate interface design is not. This paper presents three user evaluations undertaken during the iterative design of Clarity, a cross-language retrieval system for rare languages, and shows how the user interaction design evolved depending on the results of usability tests. The first test was instrumental to identify weaknesses in both functionalities and interface; the second was run to determine if query translation should be shown or not; the final was a global assessment and focussed on user satisfaction criteria. Lessons were learned at every stage of the process leading to a much more informed view of what a cross-language retrieval system should offer to users

Blind Normalization of Speech From Different Channels

We show how to construct a channel-independent representation of speech that has propagated through a noisy reverberant channel. This is done by blindly rescaling the cepstral time series by a non-linear function, with the form of this scale function being determined by previously encountered cepstra from that channel. The rescaled form of the time series is an invariant property of it in the following sense: it is unaffected if the time series is transformed by any time-independent invertible distortion. Because a linear channel with stationary noise and impulse response transforms cepstra in this way, the new technique can be used to remove the channel dependence of a cepstral time series. In experiments, the method achieved greater channel-independence than cepstral mean normalization, and it was comparable to the combination of cepstral mean normalization and spectral subtraction, despite the fact that no measurements of channel noise or reverberations were required (unlike spectral subtraction).Comment: 25 pages, 7 figure

Initial experiments concerning quantum information processing in rare-earth-ion doped crystals

In this paper initial experiments towards constructing simple quantum gates in a solid state material are presented. Instead of using specially tailored materials, the aim is to select a subset of randomly distributed ions in the material, which have the interaction necessary to control each other and therefore can be used to do quantum logic operations. The experimental results demonstrate that part of an inhomogeneously broadened absorption line can be selected as a qubit and that a subset of ions in the material can control the resonance frequency of other ions. This opens the way for the construction of quantum gates in rare-earth-ion doped crystals.Comment: 24 pages, including 12 figure

Pro-Secretory Activity and Pharmacology in Rabbits of an Aminophenyl-1,3,5-Triazine CFTR Activator for Dry Eye Disorders.

PurposePharmacological activation of ocular surface cystic fibrosis transmembrane conductance regulator (CFTR) chloride channels is a potential pro-secretory approach to treat dry eye disorders. We previously reported the discovery of aminophenyl-1,3,5-triazines, one of which, N-methyl-N-phenyl-6-(2,2,3,3-tetrafluoropropoxy)-1,3,5-triazine-2,4-diamine (herein called CFTRact-K267), fully activated human wildtype CFTR with EC50 ∼ 30 nM and increased tear volume for 8 hours in mice. Here, functional and pharmacological studies of CFTRact-K267 were done in adult New Zealand white rabbits.MethodsCFTR chloride conductance was measured in vivo by ocular surface potential differences and in ex vivo conjunctiva by short-circuit current. Tear volume was measured by the Schirmer tear test II and CFTRact-K267 pharmacokinetics and tissue distribution by liquid chromatography/mass spectrometry. Toxicity profile was studied for 28 days with twice-daily topical administration.ResultsElectrophysiological measurements in vivo and in ex vivo conjunctiva demonstrated CFTR activation by CFTRact-K267. A single topical dose of 3 nmol CFTRact-K267 increased tear production by >5 mm for 9 hours by the Schirmer tear test, with predicted therapeutic concentrations maintained in tear fluid. No tachyphylaxis was seen following 28-day twice-daily administration, and changes were not observed in corneal surface integrity or thickness, intraocular pressure, or ocular histology. At day 28, CFTRact-K267 was concentrated in the cornea and conjunctiva and was not detectable in blood or peripheral organs.ConclusionsThese studies support the development of CFTRact-K267 as a pro-secretory therapy for dry eye disorders

Kinetostatic Analysis and Solution Classification of a Planar Tensegrity Mechanism

Tensegrity mechanisms have several interesting properties that make them suitable for a number of applications. Their analysis is generally challenging because the static equilibrium conditions often result in complex equations. A class of planar one-degree-of-freedom (dof) tensegrity mechanisms with three linear springs is analyzed in detail in this paper. The kinetostatic equations are derived and solved under several loading and geometric conditions. It is shown that these mechanisms exhibit up to six equilibrium configurations, of which one or two are stable. Discriminant varieties and cylindrical algebraic decomposition combined with Groebner base elimination are used to classify solutions as function of the input parameters.Comment: 7th IFToMM International Workshop on Computational Kinematics, May 2017, Poitiers, France. 201