Assessing the motivational effects of ethanol in mice using a discrete-trial current-intensity intracranial self-stimulation procedure.

BackgroundAlcohol (ethanol) produces both rewarding and aversive effects, and sensitivity to these effects is associated with risk for an alcohol use disorder (AUD). Measurement of these motivational effects in animal models is an important but challenging aspect of preclinical research into the neurobiology of AUD. Here, we evaluated whether a discrete-trial current-intensity intracranial self-stimulation (ICSS) procedure can be used to assess both reward-enhancing and aversive responses to ethanol in mice.MethodsMale and female C57BL/6J mice were surgically implanted with bipolar stimulating electrodes targeting the medial forebrain bundle and trained on a discrete-trial current-intensity ICSS procedure. Mice were tested for changes in response thresholds after various doses of ethanol (0.5 g/kg-1.75 g/kg; n = 5-7 per dose), using a Latin square design.ResultsA 1 g/kg dose of ethanol produced a significant reward-enhancement (i.e., lowered response thresholds), whereas a 1.75 g/kg dose produced an aversive effect (elevated response thresholds). Ethanol doses from 1 to 1.75 g/kg increased response latencies as compared to saline treatment.ConclusionsThe discrete-trial current-intensity ICSS procedure is an effective assay for measuring both reward-enhancing responses to ethanol as well as aversive responses in the same animal. This should prove to be a useful tool for assessing the effects of experimental manipulations on the motivational effects of ethanol in mice

Radial distribution of gas and dust in spiral galaxies: The case of M 99 (NGC 4254) and M 100 (NGC 4321)

By combining Herschel-SPIRE data with archival Spitzer, H i , and CO maps, we investigate the spatial distribution of gas and dust in the two famous grand-design spirals M 99 and M 100 in the Virgo cluster. Thanks to the unique resolution and sensitivity of the Herschel-SPIRE photometer, we are for the first time able to measure the distribution and extent of cool, submillimetre (submm)-emitting dust inside and beyond the optical radius. We compare this with the radial variation in both the gas mass and the metallicity. Although we adopt a model-independent, phenomenological approach, our analysis provides important insights. We find the dust extending to at least the optical radius of the galaxy and showing breaks in its radial profiles at similar positions as the stellar distribution. The colour indices f350/f500 and f250/f350 decrease radially consistent with the temperature decreasing with radius. We also find evidence of an increasing gas to dust ratio with radius in the outer regions of both galaxies

Communication Enhancement Through Quantum Coherent Control of NN Channels in an Indefinite Causal-order Scenario

In quantum Shannon theory, transmission of information is enhanced by quantum features. Up to very recently, the trajectories of transmission remained fully classical. Recently, a new paradigm was proposed by playing quantum tricks on two completely depolarizing quantum channels i.e. using coherent control in space or time of the two quantum channels. We extend here this control to the transmission of information through a network of an arbitrary number $N$ of channels with arbitrary individual capacity i.e. information preservation characteristics in the case of indefinite causal order. We propose a formalism to assess information transmission in the most general case of $N$ channels in an indefinite causal order scenario yielding the output of such transmission. Then we explicitly derive the quantum switch output and the associated Holevo limit of the information transmission for $N=2$, $N=3$ as a function of all involved parameters. We find in the case $N=3$ that the transmission of information for three channels is twice of transmission of the two channel case when a full superposition of all possible causal orders is used

My Little Rose Of Romany

https://digitalcommons.library.umaine.edu/mmb-vp/2205/thumbnail.jp

Mapping the interstellar medium in galaxies with Herschel/SPIRE

The standard method of mapping the interstellar medium in a galaxy, by observing the molecular gas in the CO 1-0 line and the atomic gas in the 21-cm line, is largely limited with current telescopes to galaxies in the nearby universe. In this letter, we use SPIRE observations of the galaxies M99 and M100 to explore the alternative approach of mapping the interstellar medium using the continuum emission from the dust. We have compared the methods by measuring the relationship between the star-formation rate and the surface density of gas in the galaxies using both methods. We find the two methods give relationships with a similar dispersion, confirming that observing the continuum emission from the dust is a promising method of mapping the interstellar medium in galaxies