An assessment of the dental resection prosthesis fixation

Department of Prosthodontics, Bukovinian State Medical University, Chernivtsi, Ukraine, Private dental clinic of Dr. R. Levandovskiy, Kolomiya, UkraineThe most effective ways of fixing the resection prostheses have been found and a perfected technique of the assessment of the carrying capacity of the prosthesis fixation for a particular patient has been worked out. The fixation of the resection prosthesis due to functional sticking and adhesion can be effective not only qualitatively but also quantitatively. It has been proved that depending on the particular clinical situation, by various methods of fixing the resection prosthesis along with the numerical evaluation of their effectiveness, the desired result to hold the prosthesis in the jaw for a long time can be achieved. The experimental studies to prove the effectiveness of resection prosthesis fixation are particularly important on condition of their correct doing and the results processing. The use of modern computer technologies (MIMICS, SolidWorks, etc.) makes it possible not only to determine the contact area of the prosthesis, but also to design the prosthesis and evaluate the properties of the tissues surrounding the prosthesis. It has been proved that in order to enhance the fixation of the complete dentures the adhesive creams should be applied as additional means. For practical health care in order to improve the fixation of resection prostheses of the upper jaw in the complete absence of teeth, it is necessary to recommend the mandatory use of adhesive creams by Superfiks, Superkorega and additional modeling of buccal cavities on the vestibular surface of the denture base

Virtual screening, synthesis and biological evaluation of DNA intercalating antiviral agents

© 2017 Elsevier Ltd This paper describes computer-aided design of new anti-viral agents against Vaccinia virus (VACV) potentially acting as nucleic acid intercalators. Earlier obtained experimental data for DNA intercalation affinities and activities against Vesicular stomatitis virus (VSV) have been used to build, respectively, pharmacophore and QSAR models. These models were used for virtual screening of a database of 245 molecules generated around typical scaffolds of known DNA intercalators. This resulted in 12 hits which then were synthesized and tested for antiviral activity against VaV together with 43 compounds earlier studied against VSV. Two compounds displaying high antiviral activity against VaV and low cytotoxicity were selected for further antiviral activity investigations

Virtual screening, synthesis and biological evaluation of DNA intercalating antiviral agents

© 2017 Elsevier Ltd This paper describes computer-aided design of new anti-viral agents against Vaccinia virus (VACV) potentially acting as nucleic acid intercalators. Earlier obtained experimental data for DNA intercalation affinities and activities against Vesicular stomatitis virus (VSV) have been used to build, respectively, pharmacophore and QSAR models. These models were used for virtual screening of a database of 245 molecules generated around typical scaffolds of known DNA intercalators. This resulted in 12 hits which then were synthesized and tested for antiviral activity against VaV together with 43 compounds earlier studied against VSV. Two compounds displaying high antiviral activity against VaV and low cytotoxicity were selected for further antiviral activity investigations

Virtual screening, synthesis and biological evaluation of DNA intercalating antiviral agents

© 2017 Elsevier Ltd This paper describes computer-aided design of new anti-viral agents against Vaccinia virus (VACV) potentially acting as nucleic acid intercalators. Earlier obtained experimental data for DNA intercalation affinities and activities against Vesicular stomatitis virus (VSV) have been used to build, respectively, pharmacophore and QSAR models. These models were used for virtual screening of a database of 245 molecules generated around typical scaffolds of known DNA intercalators. This resulted in 12 hits which then were synthesized and tested for antiviral activity against VaV together with 43 compounds earlier studied against VSV. Two compounds displaying high antiviral activity against VaV and low cytotoxicity were selected for further antiviral activity investigations

Virtual screening, synthesis and biological evaluation of DNA intercalating antiviral agents

© 2017 Elsevier Ltd This paper describes computer-aided design of new anti-viral agents against Vaccinia virus (VACV) potentially acting as nucleic acid intercalators. Earlier obtained experimental data for DNA intercalation affinities and activities against Vesicular stomatitis virus (VSV) have been used to build, respectively, pharmacophore and QSAR models. These models were used for virtual screening of a database of 245 molecules generated around typical scaffolds of known DNA intercalators. This resulted in 12 hits which then were synthesized and tested for antiviral activity against VaV together with 43 compounds earlier studied against VSV. Two compounds displaying high antiviral activity against VaV and low cytotoxicity were selected for further antiviral activity investigations