11 research outputs found
Impact of Resistance Training on Balance and Gait in Multiple Sclerosis
Multiple sclerosis (MS) is an incurable neurodegenerative disease whose symptoms are only partially relieved by pharmaceutical intervention. Disability due to this disease process can impede activities of daily living and decrease quality of life, both for MS patients and for their care partners and families. A nonrandomized, nonblinded prospective cohort study of 45 patients with MS was undertaken to investigate the impact of an exercise program emphasizing resistance training on balance and gait. This article presents data for the first 33 participants to complete the study protocol. The exercise program consisted of twice-weekly 50-minute sessions for 6 months. At 3 months and 6 months, statistically significant improvements (P \u3c .05) from baseline were observed for the following measures: Nine-Hole Peg Test, 2- and 3-second Paced Auditory Serial Addition Test, Modified Fatigue Impact Scale, NeuroCom Balance Master (NeuroCom International, Inc, Clackamas, OR), Timed Up and Go test, and Berg Balance Scale. Three-dimensional biomechanical gait analysis showed increased knee power generation during midstance and increased hip power generation during terminal stance. To determine whether individuals with varying levels of disability responded to exercise in a similar fashion, participants were divided into two subgroups based on Expanded Disability Status Scale score: little or no disability (EDSS score 1.0–4.0) and mild-to-moderate disability (EDSS score 4.5–6.5). No statistically significant differences in results were found. The results of this study indicate that participation in a resistance training program improves MS patients\u27 ability to walk and to generate muscular forces during locomotion
Book Reviews: Handbook of Multiple Sclerosis by Khurram Bashir and John N. Whitaker. Published in 2001 by Lippincott, Williams & Wilkins, Philadelphia, 248 pages, $39.95
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Modification of type I collagenous gels by alveolar epithelial cells
Contraction of type I collagen gels is an in vitro model of tissue remodeling. In addition to fibroblasts, some epithelial cells can mediate this process. We therefore hypothesized that alveolar epithelial cells might contract extracellular matrices and have the potential to directly participate in the remodeling of the lung after alveolar injury. A549 cells were plated on top of collagen gels, and the gels were floated in culture medium. A549 cells contracted the gels in a time- and cell density–dependent manner. A549 cells, as well as human bronchial epithelial cells (HBEC) and rat alveolar epithelial cells (RalvEC) contracted collagen gels more when they were plated on top of the gel than when they were embedded inside, in contrast to human fetal lung fibroblast (HFL1), which contracted more when cast inside. The amount of hydroxyproline in the collagen gels remained unchanged throughout the contraction. Anti– β1 integrin antibody inhibited A549 cell–mediated contraction. Transforming growth factor β a..