11 research outputs found

    Economic evaluation of prescribing conventional and newer oral anticoagulants in older adults.

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    INTRODUCTION: Anticoagulants refer to a variety of agents that inhibit one or more steps in the coagulation cascade. Generally, clinical conditions that require the prescribing of an oral anticoagulant increase in frequency with age. However, a major challenge of anticoagulation use among older patients is that this group of patients also experience the highest bleeding risk. To date, economic evaluation of prescribing of anticoagulants that includes the novel or newer oral anticoagulants (NOACs) in older adults has not been conducted and is warranted. Areas covered: A review of articles that evaluated the cost of prescribing conventional (e.g. vitamin K antagonists) and NOACs (e.g. direct thrombin inhibitors and direct factor Xa inhibitors) in older adults. Expert commentary: While the use of NOACs significantly increases the cost of the initial treatment for thromboembolic disorders, they are still considered cost-effective relative to warfarin since they offer reduced risk of intracranial haemorrhagic events. The optimum anticoagulation with warfarin can be achieved by providing specialised care; clinics managed by pharmacists have been shown to be cost-effective relative to usual care. There are suggestions that genotyping the CYP2C9 and VKORC1 genes is useful for determining a more appropriate initial dose and thereby increasing the effectiveness and safety of warfarin

    A 1-V24-GHz 17.5-mW phase-locked loop in a 0.18-mu m CMOS process

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    A 1-V 24-GHz 17.5-mW fully integrated phase-locked loop employing a transformer-feedback voltage-controlled oscillator and a stacked divide-by-2 frequency divider for low voltage and low power is presented. Implemented in a 0.18-mu m CMOS process and operated at 24 GHz with a IN supply, the PLL measures in-band phase noise of -106.3 dBc at a frequency offset of 100 kHz and out-of-band phase noise of -119.1 dBc/Hz at a frequency offset of 10 MHz. The PLL dissipates 17.5 mW and occupies a core area of 0.55 mm(2)

    Study of platelet-mediated neurotoxicity in rat brain.

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