8,652 research outputs found
Quantum fluctuations in coupled dark solitons in trapped Bose-Einstein condensates
We show that the quantum fluctuations associated with the Bogoliubov
quasiparticle vacuum can be strongly concentrated inside dark solitons in a
trapped Bose Einstein condensate. We identify a finite number of anomalous
modes that are responsible for such quantum phenomena. The fluctuations in
these anomalous modes correspond to the `zero-point' oscillations in coupled
dark solitons.Comment: 4 pages, 3 figure
Perturbative Approach to the Quasinormal Modes of Dirty Black Holes
Using a recently developed perturbation theory for uasinormal modes (QNM's),
we evaluate the shifts in the real and imaginary parts of the QNM frequencies
due to a quasi-static perturbation of the black hole spacetime. We show the
perturbed QNM spectrum of a black hole can have interesting features using a
simple model based on the scalar wave equation.Comment: Published in PR
Episodic synchronization in dynamically driven neurons
We examine the response of type II excitable neurons to trains of synaptic
pulses, as a function of the pulse frequency and amplitude. We show that the
resonant behavior characteristic of type II excitability, already described for
harmonic inputs, is also present for pulsed inputs. With this in mind, we study
the response of neurons to pulsed input trains whose frequency varies
continuously in time, and observe that the receiving neuron synchronizes
episodically to the input pulses, whenever the pulse frequency lies within the
neuron's locking range. We propose this behavior as a mechanism of rate-code
detection in neuronal populations. The results are obtained both in numerical
simulations of the Morris-Lecar model and in an electronic implementation of
the FitzHugh-Nagumo system, evidencing the robustness of the phenomenon.Comment: 7 pages, 8 figure
Multi-wavelength emissions from the millisecond pulsar binary PSR J1023+0038 during an accretion active state
Recent observations strongly suggest that the millisecond pulsar binary PSR
J1023+0038 has developed an accretion disk since 2013 June. We present a
multi-wavelength analysis of PSR J1023+0038, which reveals that 1) its
gamma-rays suddenly brightened within a few days in June/July 2013 and has
remained at a high gamma-ray state for several months; 2) both UV and X-ray
fluxes have increased by roughly an order of magnitude, and 3) the spectral
energy distribution has changed significantly after the gamma-ray sudden flux
change. Time variabilities associated with UV and X-rays are on the order of
100-500 seconds and 50-100 seconds, respectively. Our model suggests that a
newly formed accretion disk due to the sudden increase of the stellar wind
could explain the changes of all these observed features. The increase of UV is
emitted from the disk, and a new component in gamma-rays is produced by inverse
Compton scattering between the new UV component and pulsar wind. The increase
of X-rays results from the enhancement of injection pulsar wind energy into the
intra-binary shock due to the increase of the stellar wind. We also predict
that the radio pulses may be blocked by the evaporated winds from the disk and
the pulsar is still powered by rotation.Comment: 8 pages, 3 figures; accepted for publication in Ap
Logarithmic perturbation theory for quasinormal modes
Logarithmic perturbation theory (LPT) is developed and applied to quasinormal
modes (QNMs) in open systems. QNMs often do not form a complete set, so LPT is
especially convenient because summation over a complete set of unperturbed
states is not required. Attention is paid to potentials with exponential tails,
and the example of a Poschl-Teller potential is briefly discussed. A numerical
method is developed that handles the exponentially large wavefunctions which
appear in dealing with QNMs.Comment: 24 pages, 4 Postscript figures, uses ioplppt.sty and epsfig.st
Electron Mass Operator in a Strong Magnetic Field and Dynamical Chiral Symmetry Breaking
The electron mass operator in a strong magnetic field is calculated. The
contribution of higher Landau levels of virtual electrons, along with the
ground Landau level, is shown to be essential in the leading log approximation.
The effect of the electron dynamical mass generation by a magnetic field is
investigated. In a model with N charged fermions, it is shown that some
critical number N_{cr} exists for any value of the electromagnetic coupling
constant alpha, such that the fermion dynamical mass is generated with a
doublet splitting for N < N_{cr}, and the dynamical mass does not arise at all
for N > N_{cr}, thus leaving the chiral symmetry unbroken.Comment: 4 pages, REVTEX4, 3 figure
Ground State Energy of the One-Component Charged Bose Gas
The model considered here is the `jellium' model in which there is a uniform,
fixed background with charge density in a large volume and in
which particles of electric charge and mass move --- the
whole system being neutral. In 1961 Foldy used Bogolubov's 1947 method to
investigate the ground state energy of this system for bosonic particles in the
large limit. He found that the energy per particle is in this limit, where .
Here we prove that this formula is correct, thereby validating, for the first
time, at least one aspect of Bogolubov's pairing theory of the Bose gasComment: 38 pages latex. Typos corrected.Lemma 6.2 change
Suppression of PD-L1 release from small extracellular vesicles promotes systemic anti-tumor immunity by targeting ORAI1 calcium channels
Blockade of immune checkpoints as a strategy of cancer cells to overcome the immune response has received ample attention in cancer research recently. In particular, expression of PD-L1 by various cancer cells has become a paradigm in this respect. Delivery of PD-L1 to its site of action occurs either by local diffusion, or else by transport via small extracellular vesicles (sEVs, commonly referred to as exosomes). Many steps of sEVs formation, their packaging with PD-L1 and their release into the extracellular space have been studied in detail. The likely dependence of release on Ca2+-signaling, however, has received little attention. This is surprising, since the intracellular Ca2+-concentration is known as a prominent regulator of many secretory processes. Here, we report on the roles of three Ca2+-dependent proteins in regulating release of PD-L1-containing sEVs, as well as on the growth of tumors in mouse models. We show that sEVs release in cancer cell lines is Ca2+-dependent and the knockdown of the gene coding the Ca2+-channel protein ORAI1 reduces Ca2+-signals and release of sEVs. Consequently, the T cell response is reinvigorated and tumor progression in mouse models is retarded. Furthermore, analysis of protein expression patterns in samples from human cancer tissue shows that the ORAI1 gene is significantly upregulated. Such upregulation is identified as an unfavorable prognostic factor for survival of patients with non-small-cell lung cancer. We show that reduced Ca2+-signaling after knockdown of ORAI1 gene also compromises the activity of melanophilin and Synaptotagmin-like protein 2, two proteins, which are important for correct localization of secretory organelles within cancer cells and their transport to sites of exocytosis. Thus, the Ca2+-channel ORAI1 and Ca2+-dependent proteins of the secretion pathway emerge as important targets for understanding and manipulating immune checkpoint blockade by PD-L1
Time series prediction via aggregation : an oracle bound including numerical cost
We address the problem of forecasting a time series meeting the Causal
Bernoulli Shift model, using a parametric set of predictors. The aggregation
technique provides a predictor with well established and quite satisfying
theoretical properties expressed by an oracle inequality for the prediction
risk. The numerical computation of the aggregated predictor usually relies on a
Markov chain Monte Carlo method whose convergence should be evaluated. In
particular, it is crucial to bound the number of simulations needed to achieve
a numerical precision of the same order as the prediction risk. In this
direction we present a fairly general result which can be seen as an oracle
inequality including the numerical cost of the predictor computation. The
numerical cost appears by letting the oracle inequality depend on the number of
simulations required in the Monte Carlo approximation. Some numerical
experiments are then carried out to support our findings
A staged approach with vincristine, adriamycin, and dexamethasone followed by bortezomib, thalidomide, and dexamethasone before autologous hematopoietic stem cell transplantation in the treatment of newly diagnosed multiple myeloma
Bortezomib-based regimens have significant activities in multiple myeloma (MM). In this study, we tested the efficacy of a total therapy with a staged approach where newly diagnosed MM patients received vincristine/adriamycin/dexamethsone (VAD). VAD-sensitive patients (â„75% paraprotein reduction) received autologous hematopoietic stem cell transplantation (auto-HSCT), whereas less VAD-sensitive patients (<75% paraprotein reduction) received bortezomib/thalidomide/dexamethasone (VTD) for further cytoreduction prior to auto-HSCT. On an intention-to-treat analysis, a progressive increase of complete remission (CR) rates was observed, with cumulative CR rates of 48% after HSCT. Seven patients progressed leading to three fatalities, of which two had central nervous system disease. The 3-year overall survival and event-free survival were 75.1% and 48.3%, respectively. Six patients developed oligoclonal reconstitution with new paraproteins. In the absence of anticoagulant prophylaxis, no patients developed deep vein thrombosis. The staged application of VAD+/âVTD/auto-HSCT resulted in an appreciable response rate and promising survivals. Our approach reduced the use of bortezomib without compromising the ultimate CR rate and is of financial significance for less affluent communities
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