此時彼刻文化研究 = Cultural studies still in the making

時光荏苒，MCS15年了！ 今年MCS年度研討會與過去有點不同，主題是「展演CROSSOVER：香港文化研究的變奏與另類新選擇」。在舉步維艱的社會政治泥沼中，我們如何理解和面對這境地？透過這次研討會，MCS表達對這個時代的關切，並在這關口中提出新概念，加入「表演研究」元素──不但帶來學術上的協同效應，而且使未來教育的路更闊、與大家走得更遠，發揮更大的潛質。 研討會分為兩部分。第一部分以MCSian的論文為引旨，透過對話去思考在當前處境如何尋找出路，由梁旭明主持，分別由吳紹奇主講〈作為歷史哲學家的班雅明：論歷史哲學兼評〈歷史哲學論綱〉〉，Kong Yee主講〈The Identity of Cheung Chau Kai-fong : The Cultural Disparity of The Northern and Southern Cheung Chau〉，古卓嵐主講〈Modern Educayshun 的啟示──從恐懼女性主義心理 到課室政治的省思〉，並由羅冠聰評論及與講者進行討論

Effectiveness of a denture hygiene intervention programme among institutionalized elders

Objectives: To evaluate the effectiveness of a denture hygiene intervention programme in terms of improving denture cleanliness and denture stomatitis. Methods: Residents at seven elderly care homes were invited to participate in a denture hygiene programme. Clinical assessment of denture stomatitis was undertaken and denture cleanliness assessed: (i) qualitatively by the Denture Cleanliness Index ratings and (ii) quantitatively by planimetric assessments of plaque coverage from digital images using Adobe Photoshop®. Individual denture hygiene instruction was provided and denture cleanser (Polident®) supplied. Six weeks later assessments of denture stomatitis and denture cleanliness were undertaken. Results: Fifty-six participants were recruited; most had evidence of denture stomatitis (82.1%, 46) and 62.5% (35) of dentures were classified as ‘very poorly cleaned’. The mean percentage of plaque coverage was 28.11 (SD 19.64) and 37.5% (21) had evidence of plaque covering more than a third of the denture surface. Denture cleanliness was associated with denture stomatitis (P0.05).Conclusion: A 6-week denture hygiene intervention programme was effective at improving denture stomatitis and denture cleanliness among residents of elderly care homes. However, persistence of problems in denture cleanliness and denture stomatitis existed and this warrants further consideration.published_or_final_versio

Effectiveness of a denture hygiene intervention programme among institutionalized elders

Objectives: To evaluate the effectiveness of a denture hygiene intervention programme in terms of improving denture cleanliness and denture stomatitis. Methods: Residents at seven elderly care homes were invited to participate in a denture hygiene programme. Clinical assessment of denture stomatitis was undertaken and denture cleanliness assessed: (i) qualitatively by the Denture Cleanliness Index ratings and (ii) quantitatively by planimetric assessments of plaque coverage from digital images using Adobe Photoshop®. Individual denture hygiene instruction was provided and denture cleanser (Polident®) supplied. Six weeks later assessments of denture stomatitis and denture cleanliness were undertaken. Results: Fifty-six participants were recruited; most had evidence of denture stomatitis (82.1%, 46) and 62.5% (35) of dentures were classified as ‘very poorly cleaned’. The mean percentage of plaque coverage was 28.11 (SD 19.64) and 37.5% (21) had evidence of plaque covering more than a third of the denture surface. Denture cleanliness was associated with denture stomatitis (P0.05).Conclusion: A 6-week denture hygiene intervention programme was effective at improving denture stomatitis and denture cleanliness among residents of elderly care homes. However, persistence of problems in denture cleanliness and denture stomatitis existed and this warrants further consideration.published_or_final_versio

Early exclusion of major adverse cardiac events in emergency department chest pain patients: A prospective observational study

Background The current evaluation of patients with chest pain presenting to an emergency department (ED) with suspected acute coronary syndrome (ACS) is a lengthy process involving serial measurements of troponin. Objective We aimed to validate the diagnostic accuracy of a Thrombolysis in Myocardial Infarction (TIMI) score with single high-sensitive cardiac troponin T (hs-cTnT) for early rule out of 30-day major adverse cardiac events (MACE), and to compare the TIMI score with combinations of heart-type fatty acid binding protein (H-FABP) and a modified HEART (history, electrocardiogram, age, risk factors, troponin) score. Methods We recruited 602 consecutive adult patients with chest pain and suspected ACS in the ED. Each patient had TIMI and HEART scores, and a point-of-care H-FABP test. Results MACE occurred in 42 (7.0%) patients within 30 days. A low risk for 30-day MACE was identified by a modified TIMI score of 0 in 65 (11%) patients, and by a HEART score ≤ 2 in 96 (16%) patients. No MACE occurred in these groups, giving both scores a sensitivity of 100% (95% confidence interval [CI] 91.6–100%), and specificity of 11.6% (95% CI 9.2–14.5%) and 17.1% (95% CI 14.2–20.5%), respectively. Use of combined TIMI and HEART scores improved the specificity further to 22.0% (95% CI 18.7–25.6%) without lowering sensitivity. Early H-FABP measurement > 7 μg/L had a sensitivity of 41.5% (95% CI 27.8–56.6%) and a specificity of 91.1% (95% CI 88.4–93.2%) for predicting 30-day MACE. Conclusions A modified TIMI score of 0 or a HEART score of ≤ 2, incorporating a single hs-cTnT level, will identify patients with low risk of 30-day MACE for early discharge within 2 h of ED arrival

Cyclic Nucleotide-Gated Channels Contribute to Thromboxane A2-Induced Contraction of Rat Small Mesenteric Arteries

Background: Thromboxane A 2 (TxA 2)-induced smooth muscle contraction has been implicated in cardiovascular, renal and respiratory diseases. This contraction can be partly attributed to TxA2-induced Ca 2+ influx, which resulted in vascular contraction via Ca 2+-calmodulin-MLCK pathway. This study aims to identify the channels that mediate TxA2-induced Ca 2+ influx in vascular smooth muscle cells. Methodology/Principal Findings: Application of U-46619, a thromboxane A2 mimic, resulted in a constriction in endothelium-denuded small mesenteric artery segments. The constriction relies on the presence of extracellular Ca 2+, because removal of extracellular Ca 2+ abolished the constriction. This constriction was partially inhibited by an L-type Ca 2+ channel inhibitor nifedipine (0.5–1 mM). The remaining component was inhibited by L-cis-diltiazem, a selective inhibitor for CNG channels, in a dose-dependent manner. Another CNG channel blocker LY83583 [6-(phenylamino)-5,8-quinolinedione] had similar effect. In the primary cultured smooth muscle cells derived from rat aorta, application of U46619 (100 nM) induced a rise in cytosolic Ca 2+ ([Ca 2+]i), which was inhibited by L-cis-diltiazem. Immunoblot experiments confirmed the presence of CNGA2 protein in vascular smooth muscle cells. Conclusions/Significance: These data suggest a functional role of CNG channels in U-46619-induced Ca 2+ influx and contraction of smooth muscle cells

An exploratory study of students' interests and concerns in sex education and its implication for practitioners

published_or_final_versionSocial WorkMasterMaster of Social Wor

Effect of LY83583 on U-46619-induced vasoconstriction in an endothelium-denuded small mesenteric artery segment.

<p><b>A</b>. A representative trace of the tension developed in the ring upon various treatments. <b>B</b>. A dose response curve showing the concentration dependent effect of LY83583 on contractions induced by U-46619 in the presence of L-type voltage-gated Ca²⁺ channels blocker. Mean ± SE (n = 4).</p

Effect of U46619 and L-<i>cis</i>-diltiazem on [Ca²⁺]_i in the primary cultured aortic smooth muscle cells.

<p>Cells were pretreated with 300 nM nifedipine to block L-type Ca²⁺ channels. <b>A</b>, <b>B</b>. Representative fluorescence images of cultured smooth muscle cells before (<b>A</b>) and after (<b>B</b>) 100 nM U46619. <b>C</b>. Summary of data showing the inhibitory effect of L-<i>cis</i>-diltiazem (100 nM) on U46619-induced [Ca²⁺]_i rises. Shown were the percentage of cells displaying U46619-induced [Ca²⁺]_i rises before and after U46619 challenge, Mean ± SE (n = 5). * p<0.05 as compared with the control.</p

Representative traces of the tension developed in endothelium-denuded small mesenteric arteries.

<p><b>A</b>. Addition of 1 mM BAPTA in Ca²⁺-free KHS prevented the U46619-induced contraction. <b>B</b>. Nifedipine significantly inhibited the U46619-induced contraction. <b>C</b>. 1 µM nifedipine was added to block the contraction induced by high K⁺ solution. After stabilization, U46619 was added to recontract the vessel, followed by the addition of 3 mM EGTA. Inset of C. similar to C, except that the U46619-induced contraction was followed by replacing the bath solution by a Ca²⁺-free KHS. n = 5.</p

Western blotting showing the expression of CNGA2 and CNGA3 proteins in rat aortic smooth muscle cells.

<p>Shown were representative images from 3 independent experiments.</p