Effect of fiber inclination on crack bridging stress in brittle fiber reinforced brittle matrix composites

behavior of brittle matrix composites is strongly affected by the bridging of cracks by fibers. In random fiber composites, fibers can lie at an angle to the crack plane. Under such conditions, the bridging stress for a certain crack opening is governed by various micromechanisms including fiber debonding, fiber bending and rupture as well as matrix spalling. While fiber debonding has been widely investigated, the coupled fiber bending/matrix spalling mechanism has received little attention. In this paper, the fiber bending/matrix spalling mechanism is analyzed by treating the fiber as a beam bent on an elastic foundation with variable stiffness and the possibility of spalling. The foundation stiffness and spalling criterion are derived from a finite element analysis. The bridging stress due to bending alone as well as the total bridging stress are then obtained for the case with brittle fibers. Through this analysis, the effect of various microstructural parameters (such as fiber and matrix moduli, matrix spalling strain and fiber/matrix interfacial friction) on the behavior of random fiber composites can be studied. Prediction of maximum bridging stress for inclined fibers based on the present model is shown to be in good agreement with experimental results.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/29939/1/0000296.pd

Exposure to titanium dioxide and other metallic oxide nanoparticles induces cytotoxicity on human neural cells and fibroblasts

The use of titanium dioxide (TiO2) in various industrial applications (eg, production of paper, plastics, cosmetics, and paints) has been expanding thereby increasing the occupational and other environmental exposure of these nanoparticles to humans and other species. However, the health effects of exposure to TiO2 nanoparticles have not been systematically assessed even though recent studies suggest that such exposure induces inflammatory responses in lung tissue and cells. Because the effects of such nanoparticles on human neural cells are unknown, we have determined the putative cytotoxic effects of these nanoparticles on human astrocytes-like astrocytoma U87 cells and compared their effects on normal human fibroblasts. We found that TiO2 micro- and nanoparticles induced cell death on both human cell types in a concentration-related manner. We further noted that zinc oxide (ZnO) nanoparticles were the most effective, TiO2 nanoparticles the second most effective, and magnesium oxide (MgO) nanoparticles the least effective in inducing cell death in U87 cells. The cell death mechanisms underlying the effects of TiO2 micro- and nanoparticles on U87 cells include apoptosis, necrosis, and possibly apoptosis-like and necrosis-like cell death types. Thus, our findings may have toxicological and other pathophysiological implications on exposure of humans and other mammalian species to metallic oxide nanoparticles

Topoisomerase II inhibitors induce DNA damage-dependent interferon responses circumventing Ebola virus immune evasion

Ebola virus (EBOV) protein VP35 inhibits production of interferon alpha/beta (IFN) by blocking RIG-I-like receptor signaling pathways, thereby promoting virus replication and pathogenesis. A high-throughput screening assay, developed to identify compounds that either inhibit or bypass VP35 IFN-antagonist function, identified five DNA intercalators as reproducible hits from a library of bioactive compounds. Four, including doxorubicin and daunorubicin, are anthracycline antibiotics that inhibit topoisomerase II and are used clinically as chemotherapeutic drugs. These compounds were demonstrated to induce IFN responses in an ATM kinase-dependent manner and to also trigger the DNA-sensing cGAS-STING pathway of IFN induction. These compounds also suppress EBOV replication in vitro and induce IFN in the presence of IFN-antagonist proteins from multiple negative-sense RNA viruses. These findings provide new insights into signaling pathways activated by important chemotherapy drugs and identify a novel therapeutic approach for IFN induction that may be exploited to inhibit RNA virus replication

Predictions of the L[CII]_{\rm[CII]}-SFR and [CII_{\rm II}] Luminosity Function at the Epoch of Reionization

We present the first predictions for the $L_{\rm [CII]}$ - SFR relation and [CII] luminosity function (LF) in the Epoch of Reionization (EoR) based on cosmological hydrodynamics simulations using the SIMBA suite plus radiative transfer calculations via S\'IGAME. The sample consists of 11,137 galaxies covering halo mass $\log M_{\rm halo}\in$[9, 12.4] $M_\odot$, star formation rate SFR$\in$[0.01, 330] $M_\odot$ yr$^{-1}$, and metallicity $<Z_{\rm gas}>_{\rm SFR}\in$[0.1, 0.9] $Z_\odot$. The simulated $L_{\rm [CII]}$-SFR relation is consistent with the range observed, but with a spread of $\simeq$0.3 dex at the high end of SFR ($>$100 $M_\odot$ yr$^{-1}$) and $\simeq$0.6 dex at the lower end, and there is tension between our predictions and the values of $L_{\rm [CII]}$ above 10$^{8.5}$ $L_\odot$ observed in some galaxies reported in the literature. The scatter in the $L_{\rm [CII]}$-SFR relation is mostly driven by galaxy properties, such that at a given SFR, galaxies with higher molecular gas mass and metallicity have higher $L_{\rm [CII]}$. The [CII] LF predicted by SIMBA is consistent with the upper limits placed by the only existing untargeted flux-limited [CII] survey at the EoR (ASPECS) and those predicted by semi-analytic models. We compare our results with existing models and discuss differences responsible for the discrepant slopes in the $L_{\rm [CII]}$-SFR relatiion.Comment: 19 pages, 14 figures, Accepted by Ap

Total Synthesis of (±)-Phomoidride D

Described herein is a synthetic strategy for the total synthesis of (±)‐phomoidride D. This highly efficient and stereoselective approach provides rapid assembly of the carbocyclic core by way of a tandem phenolic oxidation/intramolecular Diels–Alder cycloaddition. A subsequent SmI2‐mediated cyclization cascade delivers an isotwistane intermediate poised for a Wharton fragmentation that unveils the requisite bicyclo[4.3.1]decene skeleton and sets the stage for synthesis completion

Review: optical fiber sensors for civil engineering applications

Optical fiber sensor (OFS) technologies have developed rapidly over the last few decades, and various types of OFS have found practical applications in the field of civil engineering. In this paper, which is resulting from the work of the RILEM technical committee “Optical fiber sensors for civil engineering applications”, different kinds of sensing techniques, including change of light intensity, interferometry, fiber Bragg grating, adsorption measurement and distributed sensing, are briefly reviewed to introduce the basic sensing principles. Then, the applications of OFS in highway structures, building structures, geotechnical structures, pipelines as well as cables monitoring are described, with focus on sensor design, installation technique and sensor performance. It is believed that the State-of-the-Art review is helpful to engineers considering the use of OFS in their projects, and can facilitate the wider application of OFS technologies in construction industry

Undergraduate research. Genomics Education Partnership

The Genomics Education Partnership offers an inclusive model for undergraduate research experiences incorporated into the academic year science curriculum, with students pooling their work to contribute to international data bases

On the Incommensurate Phase of Pure and Doped Spin-Peierls System CuGeO_3

Phases and phase transitions in pure and doped spin-Peierls system CuGeO_3 are considered on the basis of a Landau-theory. In particular we discuss the critical behaviour, the soliton width and the low temperature specific heat of the incommensurate phase. We show, that dilution leads always to the destruction of long range order in this phase, which is replaced by an algebraic decay of correlations if the disorder is weak.Comment: 4 pages revtex, no figure