Macular edema in multiple evanescent white dot syndrome

Eletroretinographic findings show that the transient decreased vision seen in patients with the multiple evanescent white dot syndrome (MEWDS) is related to metabolic disturbances at the level of the retinal pigment epithelium and photoreceptor complex. In this paper, we present a patient with a typical picture of MEWDS associated to macular edema, which could also be a factor to reduce vision in this disorder. Case report of a 53-year-old woman complaining about unilateral decreased vision of 7 days' duration was sent to our retina clinic. A complete ophthalmic examination was performed as well as fluorescein angiography, indocyanine green angiography, Goldmann visual fields and optical coherence tomography (OCT). Best-corrected visual acuity was 20/40 and 20/20, in the right and left eye respectively. Ophthalmoscopy of the affected eye revealed multiple focal outer retinal gray lesions in the perimacular and peripapillary region. There were several orange puntate lesions in the foveolar region. Fluorescein angiography disclosed faint multiple foci of staining in the perimacular and peripapillary area, and some staining of the optic disc. A discrete hyperfluorescence was also observed in the foveal region. OCT disclosed an increase in foveal thickness (231 µm), approximately 25% thicker than the opposite normal eye (186 µm). Within 3 months her visual acuity had returned to 20/20 and the foveal thickness returned to a normal value (189 ìm). Although the mechanism of transitory blurred vision is not completely elucidated in cases of MEWDS, we suggest that macular edema may play a role

Immunohistochemical analysis of pdgfr-alpha, pdgfr-beta and c-abl in retinoblastoma: potential therapeutic targets

Background: Our laboratory previously reported that imatinib mesylate (IM) has an inhibitory effect on two retinoblastoma (Rb) cell lines in vitro. Aims: The purpose of this project was to determine the immunoexpression of platelet-derived growth factor receptor (PDGFR)-alpha, PDGFR-beta and c-Abl in 61 human samples of Rb to determine if IM-sensitive receptors are present. Additionally, this paper seeks to establish a correlation between the expression of PDGFR, c-Abl and the histopathological prognosis. Methods: Sixty-one paraffin-embedded Rbs were collected from the Henry C. Witelson Ocular Pathology Registry. PDGFR-alpha, PDGFR-beta and c-Abl immunostaining was performed according to the protocol provided by Ventana Medical System Inc. Immunoreactivity was correlated with the presence or absence of invasion into the choroid and optic nerve. Results: Overall, c-Abl expression was identified in 50 out of 61 specimens (81.97%), PDGFR-alpha was identified in 20 out of 60 specimens (33.33%) and PDGFR-beta expression was identified in 57 out of 61 specimens (93.44%). Histopathological prognosis was not correlated with immunoreactivity except in the case of PDGFR-beta. Conclusions: Rb is a cancer that expresses PDGFR-alpha, PDGFR-beta and c-Abl, which are known targets of IM. These markers may be responsible for the documented therapeutic effect of IM on Rb cell lines. (C) 2016 S. Karger AG, BaselDepartment of Ophthalmology and Pathology, The McGill University Health Center and Henry C. Witelson Ocular Pathology Laboratory, Montreal, Que., CanadaInstituto Brasileiro de Oftalmologia, Rio de JaneiroDepartment of Ophthalmology, Federal University of São Paulo - UNIFESP/EPM, São Paulo, BrazilDepartment of Ophthalmology, Federal University of São Paulo - UNIFESP/EPM, São Paulo, BrazilWeb of Scienc