Успешное протезирование при травматическом повреждении бедренных сосудов: клинический случай

Background. Injury to the main vessels is often accompanied by life-threatening bleeding, permanent disability or death. In the modern literature, only isolated cases of reconstructive surgery for major vein injury are described, their long-term results are insufficiently studied, there is little information about the introduction of telemedicine technologies into the practice of emergency angiosurgical care. The aim of the study is to demonstrate the immediate and long-term results of the joint work of trauma surgeons and angiosurgeons in helping a patient with injury to the main femoral vessels. Case presentation. The results of treatment of the patient with the diagnosis: laceration of the upper third of the right thigh with rupture of the common femoral vein and superficial femoral artery and the development of threatening ischemia of the right lower limb; severe blood loss; hemorrhagic shock IV; severity of injury: VPH SP 33; MESS 7. Treatment of the patient took place in several stages. At the first of them, hemostasis was performed, the hemorrhagic shock was resolved. Further, the patient was consulted by an angiosurgeon through telecommunication technologies, after which it was decided to include an angiosurgeon in the surgical team. The prosthetics of femoral vessels was performed: the main venous and arterial blood flow was restored in the affected limb. The patient was discharged in a satisfactory condition with no signs of thrombosis. Conclusions. Compliance with consistent actions in helping a patient with a vascular injury prevents the development of a deadly triad and a fatal outcome. The use of telemedicine consultations provides the angiosurgeon with the opportunity to remotely assess the clinical picture, the severity of the injury, discuss the sequence and volume of necessary medical care at the place of primary hospitalization. Performing reconstructive surgeries using various types of grafts allows you to restore the main blood flow through damaged vessels with good immediate and long-term results.Актуальность. Повреждение магистральных сосудов нередко сопровождается жизнеугрожающим кровотечением, стойкой утратой трудоспособности или летальным исходом. В современной литературе описаны лишь единичные случаи реконструктивных вмешательств при травме магистральных вен, недостаточно изучены их отдаленные результаты, мало информации о внедрении телемедицинских технологий в практику неотложной ангиохирургической помощи. Описание случая. Представлены результаты оказания ангиохирургической помощи пострадавшему с диагнозом: рваная рана верхней трети правого бедра с разрывом общей бедренной вены и поверхностной бедренной артерии, развитие угрожающей ишемии правой нижней конечности; кровопотеря тяжелой степени; геморрагический шок IV степени. Тяжесть травмы: ВПХ СП 33; MESS 7. Оказание помощи пострадавшему проходило в несколько этапов. На первом этапе была выполнена остановка кровотечения, пациент выведен из геморрагического шока. Затем была проведена телемедицинская консультация, после чего было принято решение о включении в бригаду ангиохирурга. Была выполнена реконструктивная операция протезирование бедренных сосудов. В пострадавшей конечности восстановлен магистральный венозный и артериальный кровоток. Пациент в удовлетворительном состоянии был выписан без признаков тромбоза. Заключение. Соблюдение последовательных действий при оказании помощи пациенту с травмой сосудов позволяет не допустить развитие смертельной триады и фатального исхода. Применение телемедицинских консультаций предоставляет ангиохирургу возможность дистанционно оценить клиническую картину, тяжесть повреждения, обсудить последовательность и объем необходимой медицинской помощи по месту первичной госпитализации. Выполнение реконструктивных операций с использованием различных видов трансплантатов позволяет восстановить магистральный кровоток по поврежденным сосудам с хорошими ближайшим и отдаленным результатами

Microwave wood chip treatment use in chemical pulp manufacturing (technical-economic assesment)

[EN] Low permeability of many wood species causes problems in the chemical pulp industry. These include: very long cooking times, high chemical consumption, large material losses, high energy consumption, and environment pollution. New microwave (MW) wood modification technology can provide an increase in wood permeability for liquids and gases that solves many of these problems. MW wood pre-treatment can increase pulp mill throughput, reduce chemical and power consumption, increase pulp quality and yield, and improve the environmental performance. Economic modelling of this new technology use in different chemical pulp mill conditions allowed to asses the effect of capital costs, electricity costs, labour costs and other cost components to specific total costs of MW chip processing. MW chip treatment costs for pulp mills with output 50,000 to 500,000 ait dry ton (ADT) per year at electricity cost range US$0.04 to US$0.24/kWh vary in the range from US$17.7 to US$60.8 per air dry ton of pulp. Electricity costs form the most significant part – 51- 69% of the total specific costs of MW chip processing at electricity costs US$0.08 to US$0.12/kWh. New technology application in different Russian conditions can provide benefits up to 7 – 22 Mil US$ per year for pulp mills with output more than 200,000 ADT/year. Ecological effect and high economic advantages of this MW technology provide good opportunity for commercialisation.Leshchinskaya, A. (2019). Microwave wood chip treatment use in chemical pulp manufacturing (technical-economic assesment). En AMPERE 2019. 17th International Conference on Microwave and High Frequency Heating. Editorial Universitat Politècnica de València. 137-143. https://doi.org/10.4995/AMPERE2019.2019.9706OCS13714

Addition to the aphid fauna of Belorussia (Homoptera: Aphidoidea) with detailed description of sexuales of Semiaphis anthrisci (Kaltenbach, 1843)

For the fi rst time, Therioaphis luteola (Börner, 1949), Aphis chloris Koch, 1854, Aphis craccae Linnaeus, 1758, Aphis galiiscabri Schrank, 1801, Aphis newtoni Theobald, 1927, Aphis thalictri Koch, 1854, Aphis (Bursaphis) epilobiaria Theobald, 1927, Brachycaudus (Appelia) tragopoginis (Kaltenbach, 1843), Brachycaudus (Brachycaudina) aconiti (Mordvilko, 1928), Dysaphis hirsutissima (Börner, 1940), Acaudinum centaureae (Koch, 1854), Hydaphias molluginis Börner, 1939, Semiaphis anthrisci (Kaltenbach, 1843), Uroleucon (Lambersius) erigeronense (Thomas, 1878) and Uroleucon (Uromelan) campanulae (Kaltenbach, 1843) are recorded from Byelorussia. The detailed description of oviparous female and male of S. anthrisci are given

Модель финансового стимулирования инновационной деятельности в промышленных отраслях: разработка и прогнозирование эффективности

The article presents the key provisions of the developed model of financial incentives for innovation activity for companies in the industrial sector. The subject of the study is economic relations formed in the process of financial incentives for innovation activity of industrial companies. The aim of the study is to present the authors’ model of financial incentives for innovation activity in the industrial sector, as well as to evaluate its effectiveness using forecasting methods. The relevance of the study is due to the existence in modern conditions of significant obstacles to financial incentives for innovation in the industrial sector: the lack of equity capital of companies, sufficiently high costs for the implementation of innovation projects, the existence of financial risk of loss of solvency by the company, as well as a lack of budget financing of innovation and state material support. The novelty of the research consists in the development of a model of financial incentives for innovation, which could be used in practice by companies operating in the industrial sector in order to increase production potential through the implementation of innovation and R&D projects. The authors apply the following methods: statistical analysis, correlation and regression analysis, forecasting, scenario analysis and construction of the trend of the GDP of the Russian Federation. Results: the authors define the structure of the modern model of financial incentives for innovation activity for industrial companies, evaluate its effectiveness using the interdependencies between the GDP of the Russian Federation and key parameters reflecting the increase in innovation activities of Russian entrepreneurship. Statistical data for forecasting the GDP of the Russian Federation were collected for the period 2010–2021. The authors conclude that the most effective scenario for the Russian innovation economy is the practical use of the developed model of financial incentives for innovation activity in highly active and mediumactive companies.В статье приведены ключевые положения разработанной модели финансового стимулирования инновационной деятельности для компаний, функционирующих в промышленных отраслях. Предмет исследования — экономические отношения, формирующиеся в процессе финансового стимулирования инновационной деятельности промышленных компаний. Цель исследования — представление авторской модели финансового стимулирования инновационной деятельности в промышленных отраслях, а также оценка ее эффективности при помощи методов прогнозирования. Актуальность исследования обусловлена существованием в современных условиях значимых препятствий финансового стимулирования инновационной деятельности в промышленных отраслях: недостатком собственного капитала у компаний, достаточно высокими издержками на осуществление инновационных проектов, существованием финансового риска потери компанией платежеспособности, а также нехваткой бюджетного финансирования инноваций и государственной материальной поддержки. Новизна исследования состоит в разработке модели финансового стимулирования инновационной деятельности, которую могли бы использовать на практике компании, функционирующие в промышленных отраслях, с целью повышения производственного потенциала за счет реализации проектов инноваций и НИОКР. Использованы методы: статистического анализа, корреляционно-регрессионного анализа, прогнозирования, сценарного анализа и построения тренда ВВП РФ. Результаты: автором определена структура современной модели финансового стимулирования инновационной деятельности для промышленных компаний, оценена ее эффективность с использованием взаимозависимостей между ВВП РФ и ключевыми параметрами, отражающими увеличение инновационной активности российского предпринимательства. Статистические данные для прогнозирования ВВП РФ были собраны за период 2010–2021 гг. Сделан вывод о том, что наиболее эффективным сценарием для российской инновационной экономики выступает практическое использование разработанной модели финансового стимулирования инновационной деятельности в высокоактивных и среднеактивных компаниях

Localization of alkaline phosphatase in bacillus intermedium Cells

Alkaline phosphatase, an enzyme secreted by Bacillus intermedius S3-19 cells to the medium, was also detected in the cell wall, membrane, and cytoplasm. The relative content of alkaline phosphatase in these cell compartments depended on the culture age and cultivation medium. The vegetative growth of B. intermedius on 0.3% lactate was characterized by increased activity of extracellular and membrane-bound phosphatases. The increase in lactate concentration to 3% did not affect the activity of membrane-bound phosphatase but led to a decrease in the activity of the extracellular enzyme. Na2UPO4 at a concentration of 0.01% diminished the activity of membrane-bound and extracellular phosphatases. CoCl2 at a concentration of 0.1 mM released membrane-bound phosphatase into the medium. By the onset of sporulation, phosphatase was predominantly localized in the medium and in the cell wall. As is evident from zymograms, the multiple molecular, forms of phosphatase varied depending on its cellular localization and growth phase

Effect of pH of medium on the dielectric properties and activity of deoxyribonucleases of Bacillus amylozyma and Serratia marcescens

It has been shown that increase in the activity of deoxyribonucleases of Bac. amylozyma, strain 9 A and Serr. marcescens strain 41 over the pH range 8·0-9·0 correlates with increase in the flexibility of the macromolecules of the enzymes. Change in the conformation of the protein macromolecules of the enzymes probably ensures the steric correspondence of the active centres of the enzymes with the molecules of the substrate, which leads to rise in their activity. © 1970

Actinomycin D Influence on Biosynthesis of Extracellular Ribonucleases by Sporulating Bacteria

The influence of actinomycin D on the synthesis of extracellular ribonucleases by "Bacillus intermedius" (binase), B.pumilus (RNAse Bp) and B.amyloliquefaciens (barnase) was studied comparatively. When added during the active synthesis of the enzymes actinomycin D stimulated the biosynthesis of binase and RNAse Bp and had no influence on the barnase biosynthesis. The response of the bacillary RNAse biosynthesis to the added actinomycin D correlated with the differences in the nucleotide sequences of the genes encoding the enzymes. The Escherichia coli SURE recombinant strains carrying the plasmids with the genes of binase, RNAse Bp and barnase under different regulatory sequences, as well as the E.coli MC4100 recombinant strains carrying the plasmids with the β-galactosidase gene under the promoters of the bacillary RNAse were isolated. However, the expression of the bacillary ribonuclease genes in the E.coli recombinant strains carrying the plasmids with the genes of the enzymes, as well as the expression of the β-galactosidase gene from the promotors of the bacillary RNAses was not stimulated by actinomycin D irrespective of the dose and addition time

Production of high-molecular-weight ribonuclease Bsn from the recombinant strain of Bacillus subtilis

Background: Ribonucleases (RNases) can be used in both basic and clinical sciences, e.g. in research on developmental processes or on antiviral and antitumor therapy. RNases have great potential as therapeutic entities. On the basis of new ribonucleases new medications can be created. Bacilli synthesize two types of secretory ribonucleases, the well-studied low-molecular-weight ribonucleases and high-molecular-weight ribonucleases. Only two RNases of the second type have so far been described: RNase Bsn from B. subtilis and binase II from B. intermedius. Materials/Methods: The activity of ribonucleases was determined from the amount of the acid-soluble products of RNA hydrolysis. The cultivation media were optimized for maximum RNase production in terms of the experimental factorial design B2 using BIOPT software. Results: Our investigation of a novel secretory ribonuclease, the Bacillus subtilis RNase Bsn expressed in the recombinant B. subtilis strain 168, showed that it is synthesized in the growth retardation phase, when inorganic phosphate is exhausted in the medium. The biosynthesis of Bsn was found to be suppressed by inorganic phosphate in the medium and activated by small amounts of the transcriptional inhibitor actinomycin D. Conclusion: Our results show that the biosynthesis of the novel secretory ribonuclease Bsn in recombinant strain Bacillus subtilis 168 is subject to negative regulation by inorganic phosphate, and is activated by small doses of actinomycin D. The stimulating effect of this antibiotic is well pronounced during the active synthesis of ribonucleases, but insignificant when ribonuclease synthesis is inhibited by Pi

“Gender” in the UN Sustainable Development Goals

Исследование посвящено анализу таких понятий, как «гендер» и «гендерная политика», определению их значения и роли в современном международном сообществе. Уделяется внимание провозглашаемому ООН принципу равенства мужчин и женщин, который находит свое отражение в Целях устойчивого развития.The study analyzes the concepts of «ender» and «gender policy», determines their significance and role in the modern international community. Attention is paid to the UN principle of equal rights for men and women, part of the Sustainable Development Goals

Investigation of the effect of bivalent metal ions and EDTA on the activity and dielectric properties of deoxyribonuclease of Bacillus amylozyma and Serratia marcescens

1. (1) Increase and reduction in the activity of deoxyribonucleases of B. amylozyma and Serratia marcescens under the influence of the ions Mg++, Mn++ Ca++ and EDTA correlate with the increase and reduction in the asymmetry of the macromolecules of the enzymes. 2. (2) The activity of the deoxyribonucleases studied was influenced by the configuration of the molecules in solution. © 1968