108 research outputs found
Geometric constrains for detecting short actin filaments by cryogenic electron tomography
Polymerization of actin into filaments can push membranes forming extensions like filopodia or lamellipodia, which are important during processes such as cell motility and phagocytosis. Similarly, small organelles or pathogens can be moved by actin polymerization. Such actin filaments can be arranged in different patterns and are usually hundreds of nanometers in length as revealed by various electron microscopy approaches. Much shorter actin filaments are involved in the motility of apicomplexan parasites. However, these short filaments have to date not been visualized in intact cells. Here, we investigated Plasmodium sporozoites, the motile forms of the malaria parasite that are transmitted by the mosquito, using cryogenic electron tomography. We detected filopodia-like extensions of the plasma membrane and observed filamentous structures in the supra-alveolar space underneath the plasma membrane. However, these filaments could not be unambiguously assigned as actin filaments. In silico simulations of EM data collection and tomographic reconstruction identify the limits in revealing the filaments due to their length, concentration and orientation
Collateral flow can prevent myocardial necrosis despite persistent coronary occlusion: insights using myocardial contrast echocardiography in patients
Π’Π΅Ρ Π½ΠΎΠ³Π΅Π½Π½ΡΠ΅ ΠΌΠ΅ΡΡΠΎΡΠΎΠΆΠ΄Π΅Π½ΠΈΡ, ΡΡΠΎΡΠΌΠΈΡΠΎΠ²Π°Π²ΡΠΈΠ΅ΡΡ Π½Π° ΠΎΠ±ΡΠ΅ΠΊΡΠ°Ρ Π³ΠΎΡΠ½ΠΎΠΏΡΠΎΠΌΡΡΠ»Π΅Π½Π½ΠΎΠ³ΠΎ ΠΏΡΠΎΠΈΠ·Π²ΠΎΠ΄ΡΡΠ²Π° Π² Π₯Π°ΠΊΠ°ΡΠΈΠΈ
ΠΡ
Π°ΡΠ°ΠΊΡΠ΅ΡΠΈΠ·ΠΎΠ²Π°Π½Ρ Π½Π΅ΠΊΠΎΡΠΎΡΡΠ΅ ΡΠ΅Ρ
Π½ΠΎΠ³Π΅Π½Π½ΡΠ΅ ΠΎΠ±ΡΠ΅ΠΊΡΡ Π³ΠΎΡΠ½ΠΎΠΏΡΠΎΠΌΡΡΠ»Π΅Π½Π½ΡΡ
ΠΏΡΠ΅Π΄ΠΏΡΠΈΡΡΠΈΠΉ Π₯Π°ΠΊΠ°ΡΠΈΠΈ, ΡΠ²Π»ΡΡΡΠΈΠ΅ΡΡ ΠΈΡΡΠΎΡΠ½ΠΈΠΊΠΎΠΌ Π²ΠΎΠ·Π΄Π΅ΠΉΡΡΠ²ΠΈΡ Π½Π° ΠΎΠΊΡΡΠΆΠ°ΡΡΡΡ ΡΡΠ΅Π΄Ρ ΠΈ ΠΏΠ΅ΡΡΠΏΠ΅ΠΊΡΠΈΠ²Π½ΡΠ΅ Π΄Π»Ρ ΠΈΠ·ΡΡΠ΅Π½ΠΈΡ Π½Π° ΠΏΡΠ΅Π΄ΠΌΠ΅Ρ ΠΏΠΎΠ»ΡΡΠ΅Π½ΠΈΡ Π΄ΠΎΠΏΠΎΠ»Π½ΠΈΡΠ΅Π»ΡΠ½ΠΎΠΉ ΠΏΡΠΎΠ΄ΡΠΊΡΠΈΠΈ
ΠΠ»Π°Π½ΠΈΡΠΎΠ²Π°Π½ΠΈΠ΅ ΠΏΡΠΎΠΈΠ·Π²ΠΎΠ΄ΡΡΠ²Π΅Π½Π½ΠΎΠΉ ΠΏΡΠΎΠ³ΡΠ°ΠΌΠΌΡ Π½Π° ΠΏΡΠ΅Π΄ΠΏΡΠΈΡΡΠΈΠΈ
ΠΠΈΠΏΠ»ΠΎΠΌΠ½Π°Ρ ΡΠ°Π±ΠΎΡΠ° ΡΠΎΠ΄Π΅ΡΠΆΠΈΡ 91 ΡΡΡΠ°Π½ΠΈΡΡ,8 ΡΠΈΡΡΠ½ΠΊΠΎΠ², 28 ΡΠ°Π±Π»ΠΈΡ, 20 ΠΈΡΠΏΠΎΠ»ΡΠ·ΠΎΠ²Π°Π½Π½ΡΡ
ΠΈΡΡΠΎΡΠ½ΠΈΠΊΠΎΠ², 3 ΠΏΡΠΈΠ»ΠΎΠΆΠ΅Π½ΠΈΡ.
ΠΠ»ΡΡΠ΅Π²ΡΠ΅ ΡΠ»ΠΎΠ²Π°: ΠΏΡΠΎΠΈΠ·Π²ΠΎΠ΄ΡΡΠ²Π΅Π½Π½Π°Ρ ΠΏΡΠΎΠ³ΡΠ°ΠΌΠΌΠ°, Π²ΡΠΏΡΡΠΊ ΠΏΡΠΎΠ΄ΡΠΊΡΠΈΠΈ, Π°ΡΡΠΎΡΡΠΈΠΌΠ΅Π½Ρ, ΡΠΈΡΠΌΠΈΡΠ½ΠΎΡΡΡ ΠΏΡΠΎΠΈΠ·Π²ΠΎΠ΄ΡΡΠ²Π°, ΠΏΠΎΡΡΡΠ΅Π»Ρ Π·Π°ΠΊΠ°Π·ΠΎΠ², ΠΏΡΠΎΠΈΠ·Π²ΠΎΠ΄ΡΡΠ²Π΅Π½Π½Π°Ρ ΠΌΠΎΡΠ½ΠΎΡΡΡ.
ΠΠ±ΡΠ΅ΠΊΡΠΎΠΌ ΠΈΡΡΠ»Π΅Π΄ΠΎΠ²Π°Π½ΠΈΡ ΡΠ²Π»ΡΠ΅ΡΡΡ ΠΠΠ Β«ΠΠ΅ΠΌΠ΅ΡΠΎΠ²ΡΠΊΠΈΠΉ ΠΌΠΎΠ»ΠΎΡΠ½ΡΠΉ ΠΊΠΎΠΌΠ±ΠΈΠ½Π°ΡΒ».
Π¦Π΅Π»Ρ Π΄ΠΈΠΏΠ»ΠΎΠΌΠ½ΠΎΠΉ ΡΠ°Π±ΠΎΡΡ - ΠΏΠ»Π°Π½ΠΈΡΠΎΠ²Π°Π½ΠΈΠ΅ ΠΏΡΠΎΠΈΠ·Π²ΠΎΠ΄ΡΡΠ²Π΅Π½Π½ΠΎΠΉ ΠΏΡΠΎΠ³ΡΠ°ΠΌΠΌΡ ΠΏΡΠ΅Π΄ΠΏΡΠΈΡΡΠΈΡ Π΄Π»Ρ ΠΏΠΎΠ²ΡΡΠ΅Π½ΠΈΡ Π΅Π³ΠΎ ΡΠ΅Π½ΡΠ°Π±Π΅Π»ΡΠ½ΠΎΡΡΠΈ.
ΠΠ΅ΡΠΎΠ΄Ρ ΠΈΡΡΠ»Π΅Π΄ΠΎΠ²Π°Π½ΠΈΠΉ: Π°Π½Π°Π»ΠΈΡΠΈΡΠ΅ΡΠΊΠΈΠΉ, ΡΠ°ΡΡΠ΅ΡΠ½ΡΠΉ, Π³ΡΠ°ΡΠΈΡΠ΅ΡΠΊΠΈΠΉ.
Π ΠΏΡΠΎΡΠ΅ΡΡΠ΅ ΠΈΡΡΠ»Π΅Π΄ΠΎΠ²Π°Π½ΠΈΡ ΠΏΡΠΎΠ²ΠΎΠ΄ΠΈΠ»ΠΈΡΡ Π°Π½Π°Π»ΠΈΠ· Π²ΡΠΏΠΎΠ»Π½Π΅Π½ΠΈΡ ΠΏΠ»Π°Π½Π° ΠΏΠΎ Π²ΡΠΏΡΡΠΊΡ ΠΈ ΡΠ΅Π°Π»ΠΈΠ·Π°ΡΠΈΠΈ ΠΏΡΠΎΠ΄ΡΠΊΡΠΈΠΈ, ΡΠΈΡΠΌΠΈΡΠ½ΠΎΡΡΠΈ ΠΏΡΠΎΠΈΠ·Π²ΠΎΠ΄ΡΡΠ²Π°, ΠΊΠ°ΡΠ΅ΡΡΠ²Π° ΠΏΡΠΎΠ΄ΡΠΊΡΠΈΠΈ, ΡΡΠ΅Π΄Ρ ΠΏΡΠ΅Π΄ΠΏΡΠΈΡΡΠΈΡ, ΠΏΠΎΡΡΡΠ΅Π»Ρ Π·Π°ΠΊΠ°Π·ΠΎΠ², ΠΈΡΠΏΠΎΠ»ΡΠ·ΠΎΠ²Π°Π½ΠΈΡ ΠΏΡΠΎΠΈΠ·Π²ΠΎΠ΄ΡΡΠ²Π΅Π½Π½ΡΡ
ΠΌΠΎΡΠ½ΠΎΡΡΠ΅ΠΉ.
Π ΡΠ΅Π·ΡΠ»ΡΡΠ°ΡΠ΅ ΠΈΡΡΠ»Π΅Π΄ΠΎΠ²Π°Π½ΠΈΡ ΠΎΠΏΡΠ΅Π΄Π΅Π»Π΅Π½ ΠΏΠ»Π°Π½ Π²ΡΠΏΡΡΠΊΠ° ΠΏΡΠΎΠ΄ΡΠΊΡΠΈΠΈ Π² Π½Π°ΡΡΡΠ°Π»ΡΠ½ΠΎΠΌ ΠΈ ΡΡΠΎΠΈΠΌΠΎΡΡΠ½ΠΎΠΌ Π²The thesis contains a 91-page,8 figures, 28 tables, 20 of references, 3 appendices.
Keywords: production program, production, range, rhythm of production, the portfolio of orders, production capacity.
The object of study is OJSC "Kemerovo dairy industrial complex".
The aim of the thesis - planning the production program of the enterprise to improve its profitability.
Research methods: analytical, design, graphics.
In the process of investigation the analysis of the plan for the production and sale of products, the rhythm of production, product quality, environment, backlog of orders, capacity utilization.
The study set out a plan of issue of products in physical and value terms, reserves of improvement of capacity utilization, assessed the effectiveness of the production program.
Level o
Myocardial contrast echocardiography is superior to Tc-99m single-photon emission computed tomography for the diagnosis of coronary artery disease in patients without prior acute myocardial infarction: A multicenter study
Π Π°Π·ΡΠ°Π±ΠΎΡΠΊΠ° ΡΠ΅Ρ Π½ΠΎΠ»ΠΎΠ³ΠΈΠΈ ΠΈΠ·Π³ΠΎΡΠΎΠ²Π»Π΅Π½ΠΈΡ Π΄Π΅ΡΠ°Π»ΠΈ Β«ΠΠΎΠ»Π΅ΡΠΎ Π·ΡΠ±ΡΠ°ΡΠΎΠ΅Β»
ΠΡΠ±ΡΠ°ΡΡΠ΅ ΠΊΠΎΠ»Π΅ΡΠ° ΡΠΈΡΠΎΠΊΠΎ ΠΏΡΠΈΠΌΠ΅Π½ΡΡΡΡΡ Π² ΠΌΠ°ΡΠΈΠ½ΠΎΡΡΡΠΎΠΈΡΠ΅Π»ΡΠ½ΠΎΠΉ ΠΎΡΡΠ°ΡΠ»ΠΈ, Π±Π»Π°Π³ΠΎΠ΄Π°ΡΡ Π½ΠΈΠΌ ΠΎΡΡΡΠ΅ΡΡΠ²Π»ΡΠ΅ΡΡΡ ΠΈΠ·ΠΌΠ΅Π½Π΅Π½ΠΈΠ΅ ΡΡΠΈΠ»ΠΈΠΉ ΠΏΠ΅ΡΠ΅Π΄Π°Π²Π°Π΅ΠΌΠΎΠ΅ ΠΎΡ ΠΈΡΠΏΠΎΠ»Π½ΠΈΡΠ΅Π»ΡΠ½ΡΡ
ΠΌΠ΅Ρ
Π°Π½ΠΈΠ·ΠΌΠΎΠ². Π Π°Π·ΡΠ°Π±ΠΎΡΠΊΠ° ΡΠ΅Ρ
Π½ΠΎΠ»ΠΎΠ³ΠΈΡΠ΅ΡΠΊΠΎΠ³ΠΎ ΠΏΡΠΎΡΠ΅ΡΡΠ° ΠΈΠ·Π³ΠΎΡΠΎΠ²Π»Π΅Π½ΠΈΡ Π΄Π΅ΡΠ°Π»ΠΈ - Π²Π°ΠΆΠ½Π°Ρ ΡΠΎΡΡΠ°Π²Π»ΡΡΡΠ°Ρ ΡΠ°ΡΡΡ ΠΏΡΠΎΠΈΠ·Π²ΠΎΠ΄ΡΡΠ²Π΅Π½Π½ΠΎΠ³ΠΎ ΠΏΡΠΎΡΠ΅ΡΡΠ°.
ΠΠ±Π΅ΡΠΏΠ΅ΡΠ΅Π½ΠΈΠ΅ ΠΏΡΠΎΠΈΠ·Π²ΠΎΠ΄ΠΈΡΠ΅Π»ΡΠ½ΠΎΡΡΠΈ ΠΏΡΠΈ ΡΠ°Π·ΡΠ°Π±ΠΎΡΠΊΠ΅ ΡΠ΅Ρ
Π½ΠΎΠ»ΠΎΠ³ΠΈΠΈ Π½Π΅Π²ΠΎΠ·ΠΌΠΎΠΆΠ½ΠΎ ΠΎΡΡΡΠ΅ΡΡΠ²ΠΈΡΡ Π±Π΅Π· ΡΠ΅ΡΠ΅Π½ΠΈΡ ΡΡΠ΄Π° Π·Π°Π΄Π°Ρ, ΠΊ ΠΊΠΎΡΠΎΡΡΠΌ ΠΎΡΠ½ΠΎΡΡΡΡΡ: Π²ΡΠ±ΠΎΡ ΠΌΠ΅ΡΠΎΠ΄ΠΎΠ² ΠΎΠ±ΡΠ°Π±ΠΎΡΠΊΠΈ ΠΏΠΎΠ²Π΅ΡΡ
Π½ΠΎΡΡΠ΅ΠΉ; Π²ΡΠ±ΠΎΡ ΡΠ΅Ρ
Π½ΠΎΠ»ΠΎΠ³ΠΈΡΠ΅ΡΠΊΠΈΡ
Π±Π°Π·; ΡΠ°ΡΡΠ΅ΡΡ ΠΌΠΈΠ½ΠΈΠΌΠ°Π»ΡΠ½ΡΡ
ΠΏΡΠΈΠΏΡΡΠΊΠΎΠ², ΡΠ΅ΠΆΠΈΠΌΠΎΠ² ΡΠ΅Π·Π°Π½ΠΈΡ; Π²ΡΠ±ΠΎΡ ΠΎΠ±ΠΎΡΡΠ΄ΠΎΠ²Π°Π½ΠΈΡ ΠΈ ΡΠ΅Ρ
Π½ΠΎΠ»ΠΎΠ³ΠΈΡΠ΅ΡΠΊΠΎΠΉ ΠΎΡΠ½Π°ΡΡΠΊΠΈ, ΡΠ΅ΠΆΡΡΠ΅Π³ΠΎ ΠΈΠ½ΡΡΡΡΠΌΠ΅Π½ΡΠ° ΠΈ Π½ΠΎΡΠΌΠΈΡΠΎΠ²Π°Π½ΠΈΠ΅ ΠΎΠΏΠ΅ΡΠ°ΡΠΈΠΉ ΡΠ΅Ρ
Π½ΠΎΠ»ΠΎΠ³ΠΈΡΠ΅ΡΠΊΠΎΠ³ΠΎ ΠΏΡΠΎΡΠ΅ΡΡΠ°. Π Π΄Π°Π½Π½ΠΎΠΉ ΡΠ°Π±ΠΎΡΠ΅ ΡΠ°ΡΡΠΌΠ°ΡΡΠΈΠ²Π°ΡΡΡΡ ΠΈ ΡΠ΅ΡΠ°ΡΡΡΡ Π²ΡΠ΅ ΠΏΠΎΡΡΠ°Π²Π»Π΅Π½Π½ΡΠ΅ Π·Π°Π΄Π°ΡΠΈ.Gear wheels are widely used in the engineering industry, thanks to them, a change in the forces transmitted from the actuators is carried out. The development of a technological process for manufacturing a part is an important part of the production process.
Provision of productivity in the development of technology cannot be carried out without solving a number of problems, which include: selection of surface treatment methods; selection of technological bases; calculations of minimum allowances, cutting conditions; selection of equipment and technological equipment, cutting tools and standardization of technological process operations. In this work, all the tasks are considered and solved
Social orientation of banks
The influence of the bank's orientation on clients and the quality of the services provided on the financial efficiency of the commercial institution (sales volume, profitability, cost reduction) was studied. The development of online banking and Internet banking is considered. The relationship between the profitability of the bank and the level of customercentricity is proved. World experience has been compared and generalized, and country specificity has been singled out in different regions of the world. The dependence between the degree of customer satisfaction and their subsequent loyalty to the bank was studied. Prospective directions of expansion of the market of banking services are outlined, and also changes in the psychology of the client that took place due to scientific and technological progress are noted. The basic directions of increase of efficiency of work of the bank personnel are allocated
ΠΡΠΎΠ±Π΅Π½Π½ΠΎΡΡΠΈ ΠΈΡΠΏΠΎΠ»ΡΠ·ΠΎΠ²Π°Π½ΠΈΡ ΠΊΡΠΎΡΡ-ΠΊΡΠ»ΡΡΡΡΠ½ΠΎΠ³ΠΎ ΠΏΠΎΠ΄Ρ ΠΎΠ΄Π° Π² ΠΌΠ΅Π½Π΅Π΄ΠΆΠΌΠ΅Π½ΡΠ΅ Π½Π° ΠΏΡΠΈΠΌΠ΅ΡΠ΅ ΠΊΠΎΠΌΠΏΠ°Π½ΠΈΠΈ "ΠΠ°Π·ΠΏΡΠΎΠΌ Π½Π΅ΡΡΡ"
ΠΡΡΠ»Π΅Π΄ΠΎΠ²Π°Π½ΠΈΠ΅ ΠΌΠ΅ΡΠΎΠ΄ΠΎΠ² ΠΈΠ·ΠΌΠ΅ΡΠ΅Π½ΠΈΡ ΡΠΎΠ»ΡΠΈΠ½Ρ ΡΡΠ΅Π½ΠΊΠΈ Π»Π΅Π³ΠΊΠΎΡΠΏΠ»Π°Π²Π½ΡΡ Π±ΡΡΠΈΠ»ΡΠ½ΡΡ ΡΡΡΠ±
Π’ΠΎΠ»ΡΠΈΠ½Π° ΡΡΠ΅Π½ΠΊΠΈ Π±ΡΡΠΈΠ»ΡΠ½ΠΎΠΉ ΡΡΡΠ±Ρ ΠΈΠ· Π°Π»ΡΠΌΠΈΠ½ΠΈΠ΅Π²ΠΎΠ³ΠΎ ΡΠΏΠ»Π°Π²Π° ΠΈΠ·ΠΌΠ΅ΡΡΠ΅ΡΡΡ Π²ΠΈΡ
ΡΠ΅ΡΠΎΠΊΠΎΠ²ΡΠΌ ΠΌΠ΅ΡΠΎΠ΄ΠΎΠΌ, Π°ΠΊΡΡΡΠΈΡΠ΅ΡΠΊΠΈΠΌ ΠΌΠ΅ΡΠΎΠ΄ΠΎΠΌ, ΠΌΠ°Π³Π½ΠΈΡΠ½ΡΠΌ ΠΌΠ΅ΡΠΎΠ΄ΠΎΠΌ, Π Π°Π΄ΠΈaΡΠΈΠΎΠ½Π½ΡΠΌ ΠΌΠ΅ΡΠΎΠ΄ΠΎΠΌ ΠΈ Π²ΠΈΠ·ΡΠ°Π»ΡΠ½ΠΎ-ΠΎΠΏΡΠΈΡΠ΅ΡΠΊΠΈΠΌ ΠΌΠ΅ΡΠΎΠ΄ΠΎΠΌ. ΠΡΠΈΠ½ΡΠΈΠΏ ΡΠΎΠΎΡΠ²Π΅ΡΡΡΠ²ΡΡΡΠ΅Π³ΠΎ ΠΈΠ½ΡΡΡΡΠΌΠ΅Π½ΡΠ° ΡΠ°ΠΊΠΆΠ΅ ΠΎΠΏΠΈΡΡΠ²Π°Π΅ΡΡΡ Ρ ΠΏΠΎΠΌΠΎΡΡΡ ΠΏΡΠΈΠ½ΡΠΈΠΏΠ° Π²ΡΡΠ΅ΡΠΏΠΎΠΌΡΠ½ΡΡΠΎΠ³ΠΎ ΠΌΠ΅ΡΠΎΠ΄Π°.Through the eddy current method, acoustic method, electromagnetic method, radiation method, visual optical method, to measure the thickness of the aluminum alloy drill pipe wall. The corresponding instrument principles are also described through the principles of the above methods
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