Sedimentary Signatures of Persistent Subglacial Meltwater Drainage From Thwaites Glacier, Antarctica

Subglacial meltwater drainage can enhance localized melting along grounding zones and beneath the ice shelves of marine-terminating glaciers. Efforts to constrain the evolution of subglacial hydrology and the resulting influence on ice stability in space and on decadal to millennial timescales are lacking. Here, we apply sedimentological, geochemical, and statistical methods to analyze sediment cores recovered offshore Thwaites Glacier, West Antarctica to reconstruct meltwater drainage activity through the pre-satellite era. We find evidence for a long-lived subglacial hydrologic system beneath Thwaites Glacier and indications that meltwater plumes are the primary mechanism of sedimentation seaward of the glacier today. Detailed core stratigraphy revealed through computed tomography scanning captures variability in drainage styles and suggests greater magnitudes of sediment-laden meltwater have been delivered to the ocean in recent centuries compared to the past several thousand years. Fundamental similarities between meltwater plume deposits offshore Thwaites Glacier and those described in association with other Antarctic glacial systems imply widespread and similar subglacial hydrologic processes that occur independently of subglacial geology. In the context of Holocene changes to the Thwaites Glacier margin, it is likely that subglacial drainage enhanced submarine melt along the grounding zone and amplified ice-shelf melt driven by oceanic processes, consistent with observations of other West Antarctic glaciers today. This study highlights the necessity of accounting for the influence of subglacial hydrology on grounding-zone and ice-shelf melt in projections of future behavior of the Thwaites Glacier ice margin and marine-based glaciers around the Antarctic continent

Dust in Supernovae and Supernova Remnants I : Formation Scenarios

Supernovae are considered as prime sources of dust in space. Observations of local supernovae over the past couple of decades have detected the presence of dust in supernova ejecta. The reddening of the high redshift quasars also indicate the presence of large masses of dust in early galaxies. Considering the top heavy IMF in the early galaxies, supernovae are assumed to be the major contributor to these large amounts of dust. However, the composition and morphology of dust grains formed in a supernova ejecta is yet to be understood with clarity. Moreover, the dust masses inferred from observations in mid-infrared and submillimeter wavelength regimes differ by two orders of magnitude or more. Therefore, the mechanism responsible for the synthesis of molecules and dust in such environments plays a crucial role in studying the evolution of cosmic dust in galaxies. This review summarises our current knowledge of dust formation in supernova ejecta and tries to quantify the role of supernovae as dust producers in a galaxy.Peer reviewe

Insights into glacial processes from micromorphology of silt-sized sediment [preprint]

Meltwater plume deposits (MPDs) from marine sediment cores have elucidated clearly connected, yet difficult to constrain, relationships between ice-marginal landform construction, grounding-zone retreat patterns, and subglacial hydrology for several glacial systems in both hemispheres. Few attempts have been made, however, to infer coveted details of subglacial hydrology, such as flow regime, drainage style, and mode(s) of sediment transport through time from grain-scale characteristics of MPDs. Using MPD, till, and ice-proximal diamicton samples collected offshore of six modern and relict glacial systems in both hemispheres, we examine whether grain-shape distributions and microtexture assemblages (collectively, grain micromorphology) of the silt fraction are the result of subglacial meltwater action, or are indistinguishable from glacial proximal and subglacial sediments from the same region. We find that of all grains imaged (n=9,400), three-quarters can be described by one-quarter of the full range of measured shape morphometrics, indicating widespread and efficient abrasive processes in subglacial environments. Microtexture analysis reveals that while grains comprising MPDs show evidence of edge rounding more often than tills, fluvial microtextures occur in modest amounts on grain surfaces. Furthermore, MPDs retain many mechanical (i.e., glacial) textures in comparable abundances to tills. Significant alteration of MPDs from till sources is observed for systems (1) for which intensive, potentially catastrophic, meltwater drainage events in the Holocene are inferred from marine geologic records, and (2) with comparatively less mature till grains and a contribution of supraglacial melt to the bed, indicating that quantifiable grain-shape alteration of MPDs may reflect a combination of young till, high-energy flow of subglacial meltwater, persistent sediment entrainment, and/or long sediment transport distances. We encourage future works to integrate grain micromorphology into site-specific marine sediment analyses, which may distinguish periods of persistent, well-connected subglacial discharge from periods of sporadic or disorganized drainage and provide context needed to estimate sediment fluxes and characterize ice response to subglacial meltwater transmission. In addition, this work demonstrates that glacial and fluvial surface textures are retained on silts in adequate abundance for microtexture analysis

Antiinflammatory therapy with canakinumab for atherosclerotic disease

BACKGROUND: Experimental and clinical data suggest that reducing inflammation without affecting lipid levels may reduce the risk of cardiovascular disease. Yet, the inflammatory hypothesis of atherothrombosis has remained unproved. METHODS: We conducted a randomized, double-blind trial of canakinumab, a therapeutic monoclonal antibody targeting interleukin-1β, involving 10,061 patients with previous myocardial infarction and a high-sensitivity C-reactive protein level of 2 mg or more per liter. The trial compared three doses of canakinumab (50 mg, 150 mg, and 300 mg, administered subcutaneously every 3 months) with placebo. The primary efficacy end point was nonfatal myocardial infarction, nonfatal stroke, or cardiovascular death. RESULTS: At 48 months, the median reduction from baseline in the high-sensitivity C-reactive protein level was 26 percentage points greater in the group that received the 50-mg dose of canakinumab, 37 percentage points greater in the 150-mg group, and 41 percentage points greater in the 300-mg group than in the placebo group. Canakinumab did not reduce lipid levels from baseline. At a median follow-up of 3.7 years, the incidence rate for the primary end point was 4.50 events per 100 person-years in the placebo group, 4.11 events per 100 person-years in the 50-mg group, 3.86 events per 100 person-years in the 150-mg group, and 3.90 events per 100 person-years in the 300-mg group. The hazard ratios as compared with placebo were as follows: in the 50-mg group, 0.93 (95% confidence interval [CI], 0.80 to 1.07; P=0.30); in the 150-mg group, 0.85 (95% CI, 0.74 to 0.98; P=0.021); and in the 300-mg group, 0.86 (95% CI, 0.75 to 0.99; P=0.031). The 150-mg dose, but not the other doses, met the prespecified multiplicity-adjusted threshold for statistical significance for the primary end point and the secondary end point that additionally included hospitalization for unstable angina that led to urgent revascularization (hazard ratio vs. placebo, 0.83; 95% CI, 0.73 to 0.95; P=0.005). Canakinumab was associated with a higher incidence of fatal infection than was placebo. There was no significant difference in all-cause mortality (hazard ratio for all canakinumab doses vs. placebo, 0.94; 95% CI, 0.83 to 1.06; P=0.31). CONCLUSIONS: Antiinflammatory therapy targeting the interleukin-1β innate immunity pathway with canakinumab at a dose of 150 mg every 3 months led to a significantly lower rate of recurrent cardiovascular events than placebo, independent of lipid-level lowering. Copyright © 2017 Massachusetts Medical Society