G 112-29 (=NLTT 18149), a Very Wide Companion to GJ 282 AB with a Common Proper Motion, Common Parallax, Common Radial Velocity and Common Age

We have made a search for common proper motion (CPM) companions to the wide binaries in the solar vicinity. We found that the binary GJ 282AB has a very distant CPM companion (NLTT 18149) at a separation s=1.09 \arcdeg. Improved spectral types and radial velocities are obtained, and ages determined for the three components. The Hipparcos trigonometric parallaxes and the new radial velocities and ages turn out to be very similar for the three stars, and provide strong evidence that they form a physical system. At a projected separation of 55733AU from GJ 282AB, NLTT 18149 ranks among the widest physical companions known.Comment: 13 pages, 3 figures, submmited to Ap

Assessing Peracetic Acid Application Methodology and Impacts on Fluidized Sand Biofilter Performance

Nitrifying biofilters oxidize harmful ammonia excreted by fish into less toxic nitrate within recirculating aquaculture systems (RAS). Biofilter performance and resulting RAS water quality largely depend on a robust microbiome that effectively converts nitrogenous wastes; however, occasional use of water disinfectants may also be necessary to reduce or eliminate specific fish pathogens. Disinfectants and sanitizers such as peracetic acid (PAA) work by disrupting microbial activity and could unintentionally alter the microbially-driven nitrification biofiltration process if allowed to circulate within an RAS. Furthermore, the target concentration and application method of PAA may influence the level of biofilter disruption. For this study, 12 replicated experimental-scale fluidized sand biofilters were dosed with PAA to achieve target concentrations ranging from 1.0-–2.5 mg/L, a typical low-dose treatment range to reduce or eliminate opportunistic pathogens. Two application methods were compared, including (i) a single pulse of PAA added every other day for five days, and (ii) smaller doses of PAA added every five minutes over four hours. The PAA decay was monitored and predosing and postdosing water quality parameters were assessed. Regardless of the target concentration or application method, PAA addition within the tested range did not cause significant disruption to the biofilters’ nitrification processes. This research demonstrates that PAA may be a viable water sanitizer for the RAS industry, although further research to refine safe application protocols is necessary.Assessing Peracetic Acid Application Methodology and Impacts on Fluidized Sand Biofilter PerformancepublishedVersio

Isatuximab in combination with lenalidomide and dexamethasone in patients with high-risk smoldering multiple myeloma: Updated safety run-in results from the randomized phase 3 ithaca study

Background: Results from a randomized, Phase 3 study by the Spanish Myeloma Group (PETHEMA/GEM) previously showed that treatment with lenalidomide plus dexamethasone (Rd) may delay progression to active disease in patients (pts) with high-risk smoldering multiple myeloma (SMM), compared with observation. To further improve outcomes, addition of the anti-CD38 antibody isatuximab (Isa) to lenalidomide and dexamethasone (Isa-Rd) for the treatment of pts with high-risk SMM is being evaluated in the ongoing, randomized, multi-center, Phase 3 ITHACA study (NCT04270409). Initial findings from the safety run-in analysis of this trial have shown a manageable safety profile and encouraging, preliminary anti-myeloma activity. We now report updated safety and efficacy results from the safety run-in part of ITHACA at a median follow-up of 19.4 months. Methods: Pts were included in the study if they had been diagnosed within 5 years with SMM (per the International Myeloma Working Group [IMWG] criteria) and had high-risk SMM according to the Mayo '20-2-20' and/or updated PETHEMA model criteria. Pts who had received prior anti-myeloma treatment were not eligible. Enrolled pts received Isa 10 mg/kg IV on day (D) 1, 8, 15, and 22 in cycle (C) 1, D1 and D15 C2-12, D1 C13-36; plus R D1-21 (25 mg C1-9; 10 mg C10-24) and d weekly (40 mg, 20 mg for ≥75 yr-old pts C1-9; 20 mg C10-24). Cycle duration was 28 days. Safety evaluations included treatment-emergent AEs (TEAEs)/serious AEs and laboratory parameters, graded by NCI-CTCAE v5.0. Response was determined by IMWG criteria (2016). Mandatory imaging by MRI and/or low-dose whole-body CT/PET-CT, and assessments of minimal residual disease (MRD, by next-generation sequencing in pts with very good partial response [VGPR] or better), were performed at protocol-defined time points. The primary study objective for the safety run-in was to confirm the recommended dose of Isa in combination with Rd. Overall response rate (ORR) and MRD negativity rate at 10-5 sensitivity were included as secondary endpoints.Sanof

General Practitioners' opinions on their practice in mental health and their collaboration with mental health professionals

BACKGROUND: Common mental health problems are mainly treated in primary care settings and collaboration with mental health services is needed. Prior to re-organisation of the mental health care offer in a geographical area, a study was organized: 1) to evaluate GPs' opinions on their day-to-day practice with Patients with Mental Health Problems (PMHP) and on relationships with Mental Health Professionals (MHPro); 2) to identify factors associated with perceived need for collaboration with MHPro and with actual collaboration. METHODS: All GPs in the South Yvelines area in France (n = 492) were informed of the implementation of a local mental health program. GPs interested in taking part (n = 180) were invited to complete a satisfaction questionnaire on their practice in the field of Mental Health and to include prospectively all PMHP consultants over an 8-day period (n = 1519). For each PMHP, data was collected on demographic and clinical profile, and on needs (met v. unmet) for collaboration with MHPro. RESULTS: A majority of GPs rated PMHP as requiring more care (83.4%), more time (92.3%), more frequent consultations (64.0%) and as being more difficult to refer (87.7%) than other patients. A minority of GPs had a satisfactory relationship with private psychiatrists (49.5%), public psychiatrists (35%) and social workers (27.8%). 53.9% had a less satisfactory relationship with MHPro than with other physicians. Needs for collaboration with a MHPro were more often felt in caring for PMHP who were young, not in employment, with mental health problems lasting for more than one year, with a history of psychiatric hospitalization, and showing reluctance to talk of psychological problems and to consult a MHPro. Needs for collaboration were more often met among PMHP with past psychiatric consultation or hospitalization and when the patient was not reluctant to consult a MHPro. Where needs were not met, GP would opt for the classic procedure of mental health referral for only 31.3% of their PMHP. CONCLUSION: GPs need targeted collaboration with MHPro to support their management of PMHP, whom they are willing to care for without systematic referral to specialists as the major therapeutic option

Adolescent learners' awareness of first language influence on their second language knowledge

This research is a replication and expansion of Lightbown and Spada (2000) which investigated the metalinguistic awareness of 11--12 year-old francophone learners of English as second language (ESL). Their research examined whether young L2 learners were able to make explicit L1 rules influencing their L2 performance. The present research builds on Lightbown and Spada (2000) by comparing their findings to those of older and more proficient francophone ESL learners (12--16 years old) in secondary school. As observed with the younger learners in Lightbown and Spada (2000), the interlanguage of the older learners revealed a clear influence of transfer of French even though they were more accurate in their overall performance. The results also indicated that the older learners were capable of considerable metalinguistic awareness regarding the target features (question formation and adverb placement). This contrasts sharply with Lightbown and Spada's (2000) in which there was no evidence of metalinguistic awareness on the part of the younger learners

Modélisation mécanique de la cochlée (application à la conduction osseuse)

TOULOUSE3-BU Sciences (315552104) / SudocSudocFranceF

Methane and Hydrogen Sulfide Production from the Anaerobic Digestion of Fish Sludge from Recirculating Aquaculture Systems: Effect of Varying Initial Solid Concentrations

Recirculating aquaculture systems (RAS) are efficient at solid waste capture and collection but generate a concentrated waste stream. Anaerobic digestion (AD) could be one potential treatment option for RAS facilities. However, the concentration of organic matter in the sludge can significantly affect the biogas quality from AD. This study evaluated the effect of fish sludge (FS) solid concentration on biogas quality. Three FS treatments consisted of different initial total solid concentrations (1.5%, 2.5%, and 3.5%) from a mixture of sludge produced by Atlantic salmon (Salmo salar) and rainbow trout (Oncorhynchus mykiss). Methane (CH4) production was measured, quantified, and normalized on a volatile solids (VS) basis. The highest solid concentration treatment produced 23% more CH4 than the lowest solid concentration (519 mL/g VS versus 422 mL/g VS, respectively). Peak CH4 production occurred on Day 7 for the lowest FS concentration (78.2 mL/day), while the highest FS concentration peaked on Day 11 (96 mL/day). Peak hydrogen sulfide (H2S) concentrations ranged from 1803–2074 ppm across treatments, signifying the requirement of downstream unit processes for H2S removal from biogas. Overall, this study demonstrated that increasing the FS concentration can significantly enhance CH4 production without affecting the stability of the digestion process

A Meta-Analysis Of Teamwork Processes: Tests Of A Multidimensional Model And Relationships With Team Effectiveness Criteria

Drawing from Marks, Mathieu, and Zaccaro (2001), we proposed that narrowly focused teamwork processes load onto 3 higher-order teamwork process dimensions, which in turn load onto a general teamwork process factor. Results of model testing using meta-analyses of relationships among narrow teamwork processes provided support for the structure of this multidimensional theory of teamwork process. Meta-analytic results also indicated that teamwork processes have positive relationships with team performance and member satisfaction, and that the relationships are similar across the teamwork dimensions and levels of process specificity. Supplemental analyses revealed that the 3 intermediate-level teamwork processes are positively and strongly related to cohesion and potency. Results of moderator analyses suggested that relationships among teamwork processes and team performance are somewhat dependent on task interdependence and team size. © 2008 BLACKWELL PUBLISHING, INC