Évaluation de l’exposition professionnelle aux cytotoxiques en milieu hospitalier

L’utilisation de médicaments cytotoxiques comme agent anticancéreux ou immunosuppresseur est aujourd’hui une pratique courante dans le traitement de nombreuses pathologies. Beaucoup sont encore administrés par voie injectable. Des services très différents sont amenés à les utiliser quotidiennement, ce qui expose les personnels travaillant à la pharmacie de l’hôpital, dans les services de soins hospitaliers ou à domicile. Le projet "CYTOPRO" visait à évaluer l’exposition aux cytotoxiques dans divers services de soins et à la pharmacie du CHU de Lille

Etude du profil des biomarqueurs d'exposition aux hydrocarbures aromatiques polycycliques en cokerie

LILLE2-BU Santé-Recherche (593502101) / SudocSudocFranceF

Etude de séroprévalence du cytomégalovirus dans une population exposée et non-exposée du CHRU de Lille

LILLE2-BU Santé-Recherche (593502101) / SudocPARIS-BIUM (751062103) / SudocSudocFranceF

Intérêt d'un questionnaire professionnel systématique chez des patients atteints de néoplasie pulmonaire ou pleurale

LILLE2-BU Santé-Recherche (593502101) / SudocPARIS-BIUM (751062103) / SudocSudocFranceF

Facteurs professionnels des cancers de vessie dans la région Nord-Pas-de-Calais (à propos de deux circuits de repérage)

LILLE2-BU Santé-Recherche (593502101) / SudocSudocFranceF

L'action du service de pathologies professionnelles du CHRU de Lille dans les avis concernant le contentieux des lésions professionnelles

LILLE2-BU Santé-Recherche (593502101) / SudocSudocFranceF

Cochlear implantation as a treatment for single-sided deafness and asymmetric hearing loss: a randomized controlled evaluation of cost-utility

Abstract Background Single-sided deafness (SSD) and asymmetric hearing loss (AHL) have recently been proposed as a new indication for cochlear implantation. There is still no recommended treatment for these hearing deficits, and most options considered rely on the transfer of sound from the poor ear to the better ear, using Contralateral Routing of the Signal (CROS) hearing aids or bone conduction (BC) devices. In contrast, cochlear implantation allows the poor ear to be stimulated and binaural hearing abilities to be partially restored. Indeed, most recently published studies have reported an improvement in the spatial localisation of an incoming sound and better speech recognition in noisy environments after cochlear implantation in SSD/AHL subjects. It also provides consistent relief of tinnitus when associated. These encouraging hearing outcomes raise the question of the cost-utility of this expensive treatment in an extended indication. Methods The final endpoint of this national multicentre study is to determine the incremental cost-utility ratio (ICUR) of cochlear implantation in comparison to the current standard of care in France through simple observation, using a randomised controlled trial. Firstly, the study comprises a prospective and descriptive part, where 150 SSD/AHL subjects try CROS hearing aids and a BC device for three weeks each. Secondly, the choice is made between CROS hearing aids, BC implanted device and cochlear implantation. Hearing outcomes and quality of life measurements are described after 6 months for the subjects who chose CROS, BC or declined any option. The subjects who opt for cochlear implantation are randomised between one group where the cochlear implant is inserted without delay and one group of simple initial observation. Hearing outcomes and quality of life measurements are compared after 6 months. Discussion The present study was designed to assess the efficiency of cochlear implantation in SSD/AHL. A favourable cost-utility ratio in this extended indication would strengthen the promising clinical results and justify a reimbursement by the health insurance. The efficiency of other options (CROS, BC) will also be described. Trial registration This research has been registered in ClinicalTrials.gov (http://www.clinicaltrials.gov/), the 29th July 2014 under the n°NCT02204618

Long-Term Effectiveness of a Lifestyle Intervention for the Primary Prevention of Type 2 Diabetes in a Low Socio-Economic Community – An Intervention Follow-Up Study on Reunion Island

Cet article est accompagné de 4 annexes publiées en ligne (Supporting Information) et disponibles au téléchargement à l'adresse suivante :doi:10.1371/journal.pone.0146095International audienceIn type 2 diabetes (T2D) prevention research, evidence for maintenance of risk factor reduction after three years of follow-up is needed. The objective of this study was to evaluate the long-term effectiveness of a combined lifestyle intervention aiming at controlling body weight (BW) and waist circumference (WC) in non-diabetic, overweight/obese adults living in a low socioeconomic community. On Reunion Island, 445 adults living in deprived areas, aged 18–40 and at high-risk for T2D, were included in an intervention versus control trial for primary prevention (2001–2002). The intervention promoted a healthy diet and moderate regular physical activity, through actions strengthening individuals or community and improving living conditions. The control group received a one-shot medical information and nutritional advices. After the end of the trial (2003), 259 of the subjects participated in a follow-up study (2010– 2011). The outcomes were the nine-year changes from baseline in BW, body mass index (BMI) and WC measurements, separately. Statistical analyses were performed on an intention to treat basis, using available and imputed datasets. At inclusion, T2D risk factors were prevalent: family history of diabetes in first-degree relatives (42%), women with a personal history of gestational diabetes (11%), total obesity (43%, median BMI 29.1 kg/m²) and central obesity (71%). At follow-up, the adjusted effect on imputed dataset was significant for WC-2.4 cm (95% confidence interval:-4.7 to-0.0 cm, p = 0.046), non-significant for BW-2.2 kg (-4.6 to +0.2 kg, p = 0.073) and BMI-0.81 kg/m² (-1.69 to +0.08 kg/m², p = 0.074). A specific long-term effect was the increased likelihood of reduction in adiposity: BW loss, BMI reduction , and WC reduction were more frequent in the intervention group. In the context of low socio-economic communities, our data support the assumption of long-term effect of lifestyle interventions targeting total obesity and central obesity two major drivers of T2D

Piège diagnostique en consultation de pathologies professionnelles : à propos d’un cas

International audienc

Urinary profile of monohydroxylated metabolites of polycyclic aromatic hydrocarbons in different indsutrial activities.

International audienc