Language and Totalitarianism

The diploma thesis Language and totalitarianism deals with the relation between these two phenomena. On the basis of key thinkers dealing with totalitarianism it formulates its own definition of totalitarianism. It presents the communication theory of Karl Wolfgang Deutsch, on which basis it points to the close relation between communication and political systems, concretely between language and totalitarianism. Language is analysed mainly on the thoughts of Ferdinand de Saussure and Ludwig Wittgenstein. Totalitarian language is explained using mainly Orwell's totalitarian language newspeak in 1984. A practical analysis of a sample of Rudé právo form the era of the communist regime in Czechoslovakia in the years 1948-1989 shows its manifestations in real use. At the end of the thesis political correctness is introduced as an example of totalitarian tendencies in liberal democracies

Primers for real time gene expression analysis.

<p>Primers for real time gene expression analysis.</p

The effect of DMSO in PMN and CD45⁺ cells in the wrist and ankle joints of KBxN-injected mice.

<p>Naïve mice serve as control mice not injected with KBxN serum (n = 3–4).</p

The effect of DMSO on the (A) IL-6, (B) PGE₂ and (C) 15 cytokine/chemokine secreted in a whole human blood assay in response to <i>E. coli</i> or (D) HSV stimulation.

<p>* denotes significant difference (P < 0.05) from non-DMSO treated, <i>E. coli</i> challenged or HSV-stimulated blood.</p

Plasma DMSO levels in mice following different routes of administration.

<p>Plasma DMSO levels in mice following different routes of administration.</p

The effect of DMSO on the gene expression of pro-inflammatory cytokines in the joints of KBxN-induced arthritic mice.

<p>*denotes significant (P<0.05) difference between DMSO and water-treated joints. ^# denotes a significant (P<0.05) difference between the fore and hind paws of water-treated mice.</p

The effect of DMSO in naïve and K/BxN-injected mice on A) blood cell composition and B) white blood cell subtypes.

<p>* denotes significant (P<0.05) difference between water and DMSO-treated mice in either naïve, or K/BxN-injected mice (n = 5).</p

Additional file 1: of Comprehensive whole genome sequence analyses yields novel genetic and structural insights for Intellectual Disability

Supplementary Methods - Additional details on methods presented succinctly in main text. (DOCX 53 kb

Additional file 4: Table S3. of Comprehensive whole genome sequence analyses yields novel genetic and structural insights for Intellectual Disability

UK10K study cohorts that comprise the positive control cohort – Table giving descriptions of the study cohorts from the UK10K project that comprised the positive control cohorts and conditions for use. (XLSX 13 kb

Additional file 5: Supplementary Figures. of Comprehensive whole genome sequence analyses yields novel genetic and structural insights for Intellectual Disability

Figure S1. IGV image and Sanger verification trace files for indel in ARID1B and missense variation in UPF1. Figure S2. UK10K mutation load – counts as per variant annotation type on one patient. Figure S3. Histogram of mutation burden per patient in the UK10K cohort. Figure S4. Pathway interactions showing convergence onto UPP pathway. Figure S5. Plots for CNV distribution for two chromosomes as called by CNAseq. (DOCX 1972 kb