73 research outputs found
Collisional Energy Loss of Fast Charged Particles in Relativistic Plasmas
Following an argument by Kirzhnits we rederive an exact expression for the
energy loss of a fast charged particle in a relativistic plasma using the
quantum field theoretical language. We compare this result to perturbative
calculations of the collisional energy loss of an energetic electron or muon in
an electron-positron plasma and of an energetic parton in the quark-gluon
plasma.Comment: 9 pages, LATEX, 2 PostScript figure
Nonlinear interaction of light with Bose-Einstein condensate: new methods to generate subpoissonian light
We consider -type model of the Bose-Einstein condensate of sodium
atoms interacting with the light. Coefficients of the Kerr-nonlinearity in the
condensate can achieve large and negative values providing the possibility for
effective control of group velocity and dispersion of the probe pulse. We find
a regime when the observation of the "slow" and "fast" light propagating
without absorption becomes achievable due to strong nonlinearity. An effective
two-level quantum model of the system is derived and studied based on the su(2)
polynomial deformation approach. We propose an efficient way for generation of
subpoissonian fields in the Bose-Einstein condensate at time-scales much
shorter than the characteristic decay time in the system. We show that the
quantum properties of the probe pulse can be controlled in BEC by the classical
coupling field.Comment: 13 pages, 6 figures, 1 tabl
Self-consistent solution of Kohn-Sham equations for infinitely extended systems with inhomogeneous electron gas
The density functional approach in the Kohn-Sham approximation is widely used
to study properties of many-electron systems. Due to the nonlinearity of the
Kohn-Sham equations, the general self-consistence searching method involves
iterations with alternate solving of the Poisson and Schr\"{o}dinger equations.
One of problems of such an approach is that the charge distribution renewed by
means of the Schr\"{o}dinger equation solution does not conform to boundary
conditions of Poisson equation for Coulomb potential. The resulting instability
or even divergence of iterations manifests itself most appreciably in the case
of infinitely extended systems. The published attempts to deal with this
problem are reduced in fact to abandoning the original iterative method and
replacing it with some approximate calculation scheme, which is usually
semi-empirical and does not permit to evaluate the extent of deviation from the
exact solution. In this work, we realize the iterative scheme of solving the
Kohn-Sham equations for extended systems with inhomogeneous electron gas, which
is based on eliminating the long-range character of Coulomb interaction as the
cause of tight coupling between charge distribution and boundary conditions.
The suggested algorithm is employed to calculate energy spectrum,
self-consistent potential, and electrostatic capacitance of the semi-infinite
degenerate electron gas bounded by infinitely high barrier, as well as the work
function and surface energy of simple metals in the jellium model. The
difference between self-consistent Hartree solutions and those taking into
account the exchange-correlation interaction is analyzed. The case study of the
metal-semiconductor tunnel contact shows this method being applied to an
infinitely extended system where the steady-state current can flow.Comment: 38 pages, 9 figures, to be published in ZhETF (J. Exp. Theor. Phys.
Frank-Condon principle and adjustment of optical waveguides with nonhomogeneous refractive indices
The adjustment of two different selfocs is considered using both exact
formulas for the mode-connection coefficients expressed in terms of Hermite
polynomials of several variables and a qualitative approach based on the
Frank-Condon principle. Several examples of the refractive-index dependence are
studied and illustrative plots for these examples are presented. The connection
with the tomographic approach to quantum states of a two-dimensional oscillator
and the Frank-Condon factors is established.Comment: 8 pages, 4 figures, published version (layout of figures changed,
typos corrected, references added
Molecular Mechanism of Capacitative Calcium Entry Deficits in Familial Alzheimer’s Disease
Poster PresentationPresenilin (PS) is the catalytic subunit of the gamma-secretase which is responsible for the cleavage of
amyloid precursor protein to form beta amyloid (Aβ). Mutations in PS associated with familial
Alzheimer’s disease (FAD) increase the Aβ plaques formation in the brain and cause neurodegeneration.
Apart from this, FAD-linked PS mutations have been demonstrated to disrupt intracellular calcium (Ca2+)
regulation. Accumulating evidence suggests that Ca2+ disruption may play a proximal role in the AD
pathogenesis. Mutant PS exaggerated Ca2+ release from the endoplasmic reticulum (ER). It also attenuated
Ca2+ entry through the capacitative Ca2+ entry (CCE) pathway, yet, the mechanism is not fully understood.
Using a human neuroblast cell line SH-SY5Y and Ca2+ imaging technique, we observed CCE deficits in
FAD-linked PS1-M146L retroviral infected cell. The attenuation of CCE in PS1 mutant cells was not
mediated by the down-regulation of STIM1 and Orai1 expression, the known essential molecular players
in the CCE pathway. Instead, we identified a molecular interaction between PS and STIM1 proteins by
immunoprecipitation. On the other hand, immunofluorescence staining showed a significant reduction in
puncta formation after ER Ca2+ depleted by thapsigargin in cells infected with PS1-M146L as compared to
the wild type PS1 infected cells. Taken together, our results suggest a molecular mechanism for the CCE
deficits in FAD associated with PS1 mutations. The interaction of mutant PS1 with STIM1 exerts a
negative impact on its oligomerization and/or its interaction with Orai1. Our results may suggest molecular
targets for the development of therapeutic agents that help to treat the disease.published_or_final_versio
CORRIE: enzyme sequence annotation with confidence estimates
Using a previously developed automated method for enzyme annotation, we report the re-annotation of the ENZYME database and the analysis of local error rates per class. In control experiments, we demonstrate that the method is able to correctly re-annotate 91% of all Enzyme Classification (EC) classes with high coverage (755 out of 827). Only 44 enzyme classes are found to contain false positives, while the remaining 28 enzyme classes are not represented. We also show cases where the re-annotation procedure results in partial overlaps for those few enzyme classes where a certain inconsistency might appear between homologous proteins, mostly due to function specificity. Our results allow the interactive exploration of the EC hierarchy for known enzyme families as well as putative enzyme sequences that may need to be classified within the EC hierarchy. These aspects of our framework have been incorporated into a web-server, called CORRIE, which stands for Correspondence Indicator Estimation and allows the interactive prediction of a functional class for putative enzymes from sequence alone, supported by probabilistic measures in the context of the pre-calculated Correspondence Indicators of known enzymes with the functional classes of the EC hierarchy. The CORRIE server is available at:
Immunohistochemistry versus microsatellite instability testing in phenotyping colorectal tumors
Purpose: To compare microsatellite instability (MSI) testing with immunohistochemical (IHC) detection of hMLH1 and hMSH2 in colorectal cancer. Patients and Methods: Colorectal cancers from 1, 144 patients were assessed for DNA mismatch repair deficiency by two methods: MSI testing and IHC detection of hMLH1 and hMSH2 gene products. High-frequency MSI (MSI-H) was defined as more than 30% instability of at least five markers; low-level MSI (MSI-L) was defined as 1% to 29% of loci unstable. Results: Of 1, 144 tumors tested, 818 showed intact expression of hMLH1 and hMSH2. Of these, 680 were microsatellite stable (MSS), 27 were MSI-H, and 111 were MSI-L. In all, 228 tumors showed absence of hMLH1 expression and 98 showed absence of hMSH2 expression: all were MSI-H. Conclusion: IHC in colorectal tumors for protein products hMLH1 and hMSH2 provides a rapid, cost-effective, sensitive (92.3%), and extremely specific (100%) method for screening for DNA mismatch repair defects. The predictive value of normal IHC for an MSS/MSI-L phenotype was 96.7%, and the predictive value of abnormal IHC was 100% for an MSI-H phenotype. Testing strategies must take into account acceptability of missing some cases of MSI-H tumors if only IHC is performed. (C) 2002 by American Society of Clinical Oncology
Positive Communication: A Theoretical Perspective
Positive communication is defined as interaction based on favourable emotions, aimed at understanding and bringing satisfaction to all the parties involved. The analysis of its constituent features allows us to describe it as constructive, emotive, effective and showing potential for development. It is argued that assertiveness is its optional feature typical of particular cultures. The structural components of positive communication are positive intentionality, involvement in the interaction, adaptation to the interlocutor and social support
TOO MANY WALLS AND NOT ENOUGH BRIDGES: THE IMPORTANCE OF INTERCULTURAL COMMUNICATION STUDIES INTRODUCTION
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