3,888 research outputs found
Seasonal and spatial dynamics of the primary vector of plasmodium knowlesi within a major transmission focus in Sabah, Malaysia
Background
The simian malaria parasite Plasmodium knowlesi is emerging as a public health problem in Southeast Asia, particularly in Malaysian Borneo where it now accounts for the greatest burden of malaria cases and deaths. Control is hindered by limited understanding of the ecology of potential vector species.
Methodology/Principal Findings
We conducted a one year longitudinal study of P. knowlesi vectors in three sites within an endemic area of Sabah, Malaysia. All mosquitoes were captured using human landing catch. Anopheles mosquitoes were dissected to determine, oocyst, sporozoites and parous rate. Anopheles balabacensis is confirmed as the primary vector of. P. knowlesi (using nested PCR) in Sabah for the first time. Vector densities were significantly higher and more seasonally variable in the village than forest or small scale farming site. However An. balabacensis survival and P. knowlesi infection rates were highest in forest and small scale farm sites. Anopheles balabacensis mostly bites humans outdoors in the early evening between 1800 to 2000hrs.
Conclusions/Significance
This study indicates transmission is unlikely to be prevented by bednets. This combined with its high vectorial capacity poses a threat to malaria elimination programmes within the region.
Author Summary
The first natural infection of Plasmodium knowlesi was reported 40 years ago. At that time it was perceived that the infection would not affect humans. However, now P. knowlesi is the predominant malaria species (38% of the cases) infecting people in Malaysia and is a notable obstacle to malaria elimination in the country. Plasmodium knowlesi has also been reported from all countries in Southeast Asia with the exception of Lao PDR and Timor Leste. In Sabah, Malaysian Borneo cases of human P. knowlesi are increasing. Thus, a comprehensive understanding of the bionomics of the vectors is required so as to enable proper control strategies. Here, we conducted a longitudinal study in Kudat district, Sabah, to determine and characterize the vectors of P. knowlesi within this transmission foci. Anopheles balabacensis was the predominant mosquito in all study sites and is confirmed as vector for P. knowlesi and other simian malaria parasites. The peak biting time was in the early part of the evening between1800 to 2000. Thus, breaking the chain of transmission is an extremely challenging task for the malaria elimination programme
Cost-benefit analysis for commissioning decisions in GEO600
Gravitational wave interferometers are complex instruments, requiring years
of commissioning to achieve the required sensitivities for the detection of
gravitational waves, of order 10^-21 in dimensionless detector strain, in the
tens of Hz to several kHz frequency band. Investigations carried out by the
GEO600 detector characterisation group have shown that detector
characterisation techniques are useful when planning for commissioning work. At
the time of writing, GEO600 is the only large scale laser interferometer
currently in operation running with a high duty factor, 70%, limited chiefly by
the time spent commissioning the detector. The number of observable
gravitational wave sources scales as the product of the volume of space to
which the detector is sensitive and the observation time, so the goal of
commissioning is to improve the detector sensitivity with the least possible
detector down time. We demonstrate a method for increasing the number of
sources observable by such a detector, by assessing the severity of
non-astrophysical noise contaminations to efficiently guide commissioning. This
method will be particularly useful in the early stages and during the initial
science runs of the aLIGO and adVirgo detectors, as they are brought up to
design performance.Comment: 17 pages, 17 figures, 2 table
In depth analysis of the Sox4 gene locus that consists of sense and natural antisense transcripts
Available online 17 February 2016SRY (Sex Determining Region Y)-Box 4 or Sox4 is an important regulator of the pan-neuronal gene expression during post-mitotic cell differentiation within the mammalian brain. Sox4 gene locus has been previously characterized with multiple sense and overlapping natural antisense transcripts [1], [2]. Here we provide accompanying data on various analyses performed and described in Ling et al. [2]. The data include a detail description of various features found at Sox4 gene locus, additional experimental data derived from RNA-Fluorescence in situ Hybridization (RNA-FISH), Western blotting, strand-specific reverse-transcription quantitative polymerase chain reaction (RT-qPCR), gain-of-function and in situ hybridization (ISH) experiments. All the additional data provided here support the existence of an endogenous small interfering- or PIWI interacting-like small RNA known as Sox4_sir3, which origin was found within the overlapping region consisting of a sense and a natural antisense transcript known as Sox4ot1.King-Hwa Ling, Peter J. Brautigan, Sarah Moore, Rachel Fraser, Melody Pui-Yee Leong, Jia-Wen Leong, Shahidee Zainal Abidin, Han-Chung Lee, Pike-See Cheah, Joy M. Raison, Milena Babic, Young Kyung Lee, Tasman Daish, Deidre M. Mattiske, Jeffrey R. Mann, David L. Adelson, Paul Q. Thomas, Christopher N. Hahn, Hamish S.Scot
Radion and Holographic Brane Gravity
The low energy effective theory for the Randall-Sundrum two brane system is
investigated with an emphasis on the role of the non-linear radion in the brane
world. The equations of motion in the bulk is solved using a low energy
expansion method. This allows us, through the junction conditions, to deduce
the effective equations of motion for the gravity on the brane. It is shown
that the gravity on the brane world is described by a quasi-scalar-tensor
theory with a specific coupling function omega(Psi) = 3 Psi / 2(1-Psi) on the
positive tension brane and omega(Phi) = -3 Phi / 2(1+Phi) on the negative
tension brane, where Psi and Phi are non-linear realizations of the radion on
the positive and negative tension branes, respectively. In contrast to the
usual scalar-tensor gravity, the quasi-scalar-tensor gravity couples with two
kinds of matter, namely, the matters on both positive and negative tension
branes, with different effective gravitational coupling constants. In
particular, the radion disguised as the scalar fields Psi and Phi couples with
the sum of the traces of the energy momentum tensor on both branes. In the
course of the derivation, it has been revealed that the radion plays an
essential role to convert the non-local Einstein gravity with the generalized
dark radiation to the local quasi-scalar-tensor gravity. For completeness, we
also derive the effective action for our theory by substituting the bulk
solution into the original action. It is also shown that the
quasi-scalar-tensor gravity works as holograms at the low energy in the sense
that the bulk geometry can be reconstructed from the solution of the
quasi-scalar-tensor gravity.Comment: Revtex4, 18 pages, revised version, conclusions unchanged, references
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MMIC power amplifiers as local oscillator drivers for FIRST
The Heterodyne Instrument for the Far-Infrared and Sub- millimeter Telescope requires local oscillators well into the terahertz frequency range. The mechanism to realize the local oscillators will involve synthesizers, active multiplier chains (AMC's) with output frequencies from 71 - 112.5 GHz, power amplifiers to amplify the AMC signals, and chains of Schottky diode multipliers to achieve terahertz frequencies. We will present the latest state-of-the-art results on 70 - 115 GHz Monolithic Millimeter-wave Integrated Circuit power amplifier technology
Brane World Effective Action at Low Energies and AdS/CFT Correspondence
A low energy iteration scheme to study nonlinear gravity in the brane world
is developed. As a result, we obtain the brane world effective action at low
energies. The relation between the geometrical approach and the approach using
the AdS/CFT correspondence is also clarified. In particular, we find
generalized dark radiation as homogeneous solutions in our iteration scheme.
Moreover, the precise correspondence between the bulk geometry and the brane
effective action is established, which gives a holographic view of the brane
world.Comment: Revtex4, 12 pages, references added. Version accepted for publicaton
in Phys. Rev.
GEO 600 and the GEO-HF upgrade program: successes and challenges
The German-British laser-interferometric gravitational wave detector GEO 600
is in its 14th year of operation since its first lock in 2001. After GEO 600
participated in science runs with other first-generation detectors, a program
known as GEO-HF began in 2009. The goal was to improve the detector sensitivity
at high frequencies, around 1 kHz and above, with technologically advanced yet
minimally invasive upgrades. Simultaneously, the detector would record science
quality data in between commissioning activities. As of early 2014, all of the
planned upgrades have been carried out and sensitivity improvements of up to a
factor of four at the high-frequency end of the observation band have been
achieved. Besides science data collection, an experimental program is ongoing
with the goal to further improve the sensitivity and evaluate future detector
technologies. We summarize the results of the GEO-HF program to date and
discuss its successes and challenges
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