Big Bang Nucleosynthesis Constraints on Brane Cosmologies

We examine constraints from Big Bang nucleosynthesis on type II Randall-Sundrum brane cosmologies with both a dark radiation component and a quadratic term that depends on the 5-dimensional Planck mass, M_5. Using limits on the abundances of deuterium and helium-4, we calculate the allowed region in the M_5-dark radiation plane and derive the precise BBN bound on M_5 alone with no dark radiation: M_5 > 13 TeV.Comment: 3 pages, 1 figure, references added, to appear in Phys. Lett.

Legumes as food ingredient: characterization, processing, and applications

Editores: Jiménez-López, José Carlos (CSIC); Clemente, Alfonso (CSIC

All-sky search for long-duration gravitational wave transients with initial LIGO

We present the results of a search for long-duration gravitational wave transients in two sets of data collected by the LIGO Hanford and LIGO Livingston detectors between November 5, 2005 and September 30, 2007, and July 7, 2009 and October 20, 2010, with a total observational time of 283.0 days and 132.9 days, respectively. The search targets gravitational wave transients of duration 10-500 s in a frequency band of 40-1000 Hz, with minimal assumptions about the signal waveform, polarization, source direction, or time of occurrence. All candidate triggers were consistent with the expected background; as a result we set 90% confidence upper limits on the rate of long-duration gravitational wave transients for different types of gravitational wave signals. For signals from black hole accretion disk instabilities, we set upper limits on the source rate density between 3.4×10-5 and 9.4×10-4 Mpc-3 yr-1 at 90% confidence. These are the first results from an all-sky search for unmodeled long-duration transient gravitational waves. © 2016 American Physical Society

All-sky search for long-duration gravitational wave transients with initial LIGO

We present the results of a search for long-duration gravitational wave transients in two sets of data collected by the LIGO Hanford and LIGO Livingston detectors between November 5, 2005 and September 30, 2007, and July 7, 2009 and October 20, 2010, with a total observational time of 283.0 days and 132.9 days, respectively. The search targets gravitational wave transients of duration 10-500 s in a frequency band of 40-1000 Hz, with minimal assumptions about the signal waveform, polarization, source direction, or time of occurrence. All candidate triggers were consistent with the expected background; as a result we set 90% confidence upper limits on the rate of long-duration gravitational wave transients for different types of gravitational wave signals. For signals from black hole accretion disk instabilities, we set upper limits on the source rate density between 3.4×10-5 and 9.4×10-4 Mpc-3 yr-1 at 90% confidence. These are the first results from an all-sky search for unmodeled long-duration transient gravitational waves. © 2016 American Physical Society

Whole-genome sequencing of chronic lymphocytic leukemia identifies subgroups with distinct biological and clinical features

The value of genome-wide over targeted driver analyses for predicting clinical outcomes of cancer patients is debated. Here, we report the whole-genome sequencing of 485 chronic lymphocytic leukemia patients enrolled in clinical trials as part of the United Kingdom’s 100,000 Genomes Project. We identify an extended catalog of recurrent coding and noncoding genetic mutations that represents a source for future studies and provide the most complete high-resolution map of structural variants, copy number changes and global genome features including telomere length, mutational signatures and genomic complexity. We demonstrate the relationship of these features with clinical outcome and show that integration of 186 distinct recurrent genomic alterations defines five genomic subgroups that associate with response to therapy, refining conventional outcome prediction. While requiring independent validation, our findings highlight the potential of whole-genome sequencing to inform future risk stratification in chronic lymphocytic leukemia

Predictable definitive impressions for multiple indirect restorations using a modified putty and wash impression procedure

Singapore Dental Journal29146-4

Low incidence of colorectal cancer in Australian ulcerative colitis patients

Background: Ulcerative colitis (UC) causes significant morbidity and patients may ultimately require colectomy. UC is also associated with an increased risk of developing colorectal cancer (CRC), which may be as high as 18% after 30 years although some recent studies have reported lower rates. Aims: This study aimed to ascertain the cumulative incidences of colectomy and CRC in Australian UC patients. Methods: The study is based on a prevalence cohort (1977–1992) of Sydney IBD patients was fi rst described in 1995 and longitudinally followed. UC patients were included in this analysis if they were either diagnosed after 1977 or had yet to experience colectomy or CRC in 1977 Cumulative incidences for colectomy and CRC were calculated by competing risk survival analysis using the statistical software R. Phenotyping was performed using the Montreal Classification. The influence of extent of colitis, sex, age at diagnosis and year of diagnosis on cumulative incidences were also examined. Results: 504 patients (267 males, median age at diagnosis 34 years) were followed up for a median of 14 years (8006 patient years). The cumulative incidence of colectomy was 15% (95% CI 11%–19%) after 10 years, 26% (95% CI 21%–30%) after 20 years and 31% (95% CI 25–36%) by 30 years. Pancolitis was associated with an increased risk of colectomy (hazard ratio of 13.15; 95% CI 3.2–54.01, P < 0.001), but neither age at diagnosis nor year of diagnosis influenced colectomy risk. CRC occurred in 24 patients for a cumulative incidence of CRC of 1% (95% CI 0–2%) at 10 years, 3% (95% CI 1–5%) at 20 years and 7% (95% CI 4%–10%) at 30 years. Patients diagnosed before 1980 had a hazard ratio for CRC of 5.2 (95% CI 1.74–15.5, P = 0.003) compared to those diagnosed ≥1980. The extent of colitis (left-sided versus pancolitis) was not found to influence CRC risk possibly due the small number of cancers (P = 0.8).Conclusion: We have demonstrated a very low incidence of CRC in this Australian cohort of UC patients. The decreased risk of developing CRC in patients diagnosed after 1980 suggests a positive effect from modern management by dedicated gastroenterologists. The finding of lower cancer rates than in other cohorts should reassure patients and physicians alike. Only a quarter of patients required colectomy within 20 years and the risk was higher for patients with pancolitis.Christian Selinger, Jane Andrews, Andrew Titman, Rupert W Leon