More than a memoir

This autobiography was written originally as a test of memory, as a means of diminishing piles of stored papers and file folders, and in an effort to record events as they actually happened. It had been my experience as a child, hearing oral histories presented by adult family members, that there was great variance in their perceptions. Perhaps I could set down the "facts" of a life and leave interpretations up to any readers. Each of the chapters was distributed to my four children, Kenneth, Marcia, James and David. Inasmuch as they read the sporadic mailings, I incorporated their corrections and tried to answer any questions they raised. I relied upon friends to check specific chapters against their memories and upon Peggy Phelps to offer penetrating criticism where she discerned opinion masquerading as fact. Diane Orona deciphered my handwriting sufficiently to produce a handsome, typed manuscript, and I thank her for her patience and her aim at perfection. Who will read such a manuscript? Who among the grandchildren or children has the time for it? With the completion of the story, can I hope that others may find it of interest? The very personal nature may decide against that. The diverse nature of the subject matter would guide toward selective readings: organic chemistry with some biochemistry and plant physiology; music, but mainly singing; bi-continental living and romance; family; travel; universities; extraneous material about foundations, research support, national and international organizations, even some talks (in the appendix). However, there is a whole to it -- the story of a sample life in the twentieth century and a bit into the twenty-first. I have found life's journey exciting and rewarding. I have been fantastically lucky. NJ

\u3cem\u3eHellingv. Carey\u3c/em\u3e Revisited: Physician Liability in the Age of Managed Care

In this article, the author proposes that the traditional custom-based standard applicable in medical malpractice cases be replaced with a reasonable, prudent physician standard that will more adequately take into account the role of the physician in rationing care. Part I of this article focuses on the heightened tension between tort and contract in managed health care. Part II of this article examines managed care cost containment techniques and their possible impact on physician decision making. Part III focuses on the widely acknowledged shortcomings of the customary standard. Part IV provides an outline of the doctrinal regime for my proposed reasonable, prudent physician standard

\u3cem\u3eHellingv. Carey\u3c/em\u3e Revisited: Physician Liability in the Age of Managed Care

In this article, the author proposes that the traditional custom-based standard applicable in medical malpractice cases be replaced with a reasonable, prudent physician standard that will more adequately take into account the role of the physician in rationing care. Part I of this article focuses on the heightened tension between tort and contract in managed health care. Part II of this article examines managed care cost containment techniques and their possible impact on physician decision making. Part III focuses on the widely acknowledged shortcomings of the customary standard. Part IV provides an outline of the doctrinal regime for my proposed reasonable, prudent physician standard

Bioorganic chemistry - a scientific endeavour in continuous transition

Bioorganic chemistry is an expanding, dynamic area of fundamental and practical interest. The new technologies needed are developed through efficient organic synthesis and spectroscopic analysis or are assimilated from advances in biological manipulations. The multifaceted origins of bioorganic chemistry are discussed, along with the use of the descriptor in the titles of journals. organizations, and meetings. In the Second International Symposium on Bioorganic Chemistry, which is cosponsored by the International Union of Pure and Applied Chemistry and the Chemical Society of Japan and is hosted by Kyushu University, the topics to be covered indicate the accelerated pace and broadening scope of the enterprise

Reclassifying Hepatic Cell Death during Liver Damage:Ferroptosis-A Novel Form of Non-Apoptotic Cell Death?

Ferroptosis has emerged as a new type of cell death in different pathological conditions, including neurological and kidney diseases and, especially, in different types of cancer. The hallmark of this regulated cell death is the presence of iron-driven lipid peroxidation; the activation of key genes related to this process such as glutathione peroxidase-4 (gpx4), acyl-CoA synthetase long-chain family member-4 (acsl4), carbonyl reductase [NADPH] 3 (cbr3), and prostaglandin peroxidase synthase-2 (ptgs2); and morphological changes including shrunken and electron-dense mitochondria. Iron overload in the liver has long been recognized as both a major trigger of liver damage in different diseases, and it is also associated with liver fibrosis. New evidence suggests that ferroptosis might be a novel type of non-apoptotic cell death in several liver diseases including non-alcoholic steatohepatitis (NASH), alcoholic liver disease (ALD), drug-induced liver injury (DILI), viral hepatitis, and hemochromatosis. The interaction between iron-related lipid peroxidation, cellular stress signals, and antioxidant systems plays a pivotal role in the development of this novel type of cell death. In addition, integrated responses from lipidic mediators together with free iron from iron-containing enzymes are essential to understanding this process. The presence of ferroptosis and the exact mechanisms leading to this non-apoptotic type of cell death in the liver remain scarcely elucidated. Recognizing ferroptosis as a novel type of cell death in the liver could lead to the understanding of the complex interaction between different types of cell death, their role in progression of liver fibrosis, the development of new biomarkers, as well as the use of modulators of ferroptosis, allowing improved theranostic approaches in the clinic