A Spectropolarimetric Comparison of the Type II-Plateau Supernovae SN 2008bk and SN 2004dj

The Type II-Plateau supernova (SN II-P) SN 2004dj was the first SN II-P for which spectropolarimetry data were obtained with fine temporal sampling before, during, and after the fall off of the photometric plateau -- the point that marks the transition from the photospheric to the nebular phase in SNe II-P. Unpolarized during the plateau, SN 2004dj showed a dramatic spike in polarization during the descent off of the plateau, and then exhibited a smooth polarization decline over the next two hundred days. This behavior was interpreted by Leonard et al. (2006) as evidence for a strongly non-spherical explosion mechanism that had imprinted asphericity only in the innermost ejecta. In this brief report, we compare nine similarly well-sampled epochs of spectropolarimetry of the Type II-P SN 2008bk to those of SN 2004dj. In contrast to SN 2004dj, SN 2008bk became polarized well before the end of the plateau and also retained a nearly constant level of polarization through the early nebular phase. Curiously, although the onset and persistence of polarization differ between the two objects, the detailed spectropolarimetric characteristics at the epochs of recorded maximum polarization for the two objects are extremely similar, feature by feature. We briefly interpret the data in light of non-Local-Thermodynamic Equilibrium, time-dependent radiative-transfer simulations specifically crafted for SN II-P ejecta.Comment: 4 pages, 1 figure, to appear in AIP conference proceedings: Stellar Polarimetry, From Birth to Death, eds. J. Hoffman, B. Whitney, and J. Bjorkma

Transims and developments of regional impact

Issued as final reportUnited States. Dept. of Transportatio

Application of a Channel Design Method to High-Solidity Cascades and Tests of an Impulse Cascade with 90 Degrees of Turning

A technique is developed for the application of a channel design method to the design of high-solidity cascades with prescribed velocity distributions as a function of arc length along the blade-element profile. The technique is applied to both incompressible and subsonic compressible, nonviscous, irrotational fluid motion. For compressible flow, the ratio of specific heats is assumed equal to -1.0. An impulse cascade with 90 degree turning was designed for incompressible flow and was tested at the design angle of attack over a range of downstream Mach number from 0.2 to coke flow. To achieve good efficiency, the cascade was designed for prescribed velocities and maximum blade loading according to limitations imposed by considerations of boundary-layer separation

The evolution of continuum polarization in Type II supernovae as a diagnostic of ejecta morphology

Linear polarization of the optical continuum of type II supernovae (SNe), together with its temporal evolution, is a promising source of information on the large-scale geometry of their ejecta. To help tap this information we have undertaken 2D polarized radiative transfer calculations to map out the possible landscape of type II SN continuum polarization (Pcont) from 20 to 300d after explosion. Our simulations are based on crafted 2D, axisymmetric ejecta constructed from 1D nonlocal thermodynamic equilibrium time-dependent radiative transfer calculations for a red-supergiant star explosion. Following the approach used in our previous work on SN2012aw, we consider a variety of bipolar explosions in which spherical symmetry is broken by the presence, within ~30deg of the poles, of material with a higher kinetic energy (up to a factor of two) and higher 56Ni abundance (up to a factor of about five, with allowance for 56Ni at high velocity). Our set of eight 2D ejecta configurations produces considerable diversity in Pcont (~7000A), although its maximum of 1-4% occurs systematically around the transition to the nebular phase. Before and after that transition, Pcont may be null, constant, rising, or decreasing, which results from the complex geometry of the depth-dependent density and ionization as well as from optical depth effects. Our modest angle-dependent explosion energy can yield Pcont of 0.5-1% at early times. Residual optical-depth effects can yield an angle-dependent SN brightness and constant polarization at nebular times. Observed values of Pcont tend to be lower than obtained here, suggesting more complicated geometries with competing large-scale structures causing polarization cancellation. Extreme asymmetries seem to be excluded.Comment: Accepted to A&

Neuregulin-1 attenuates mortality associated with experimental cerebral malaria.

BackgroundCerebral Malaria (CM) is a diffuse encephalopathy caused by Plasmodium falciparum infection. Despite availability of antimalarial drugs, CM-associated mortality remains high at approximately 30% and a subset of survivors develop neurological and cognitive disabilities. While antimalarials are effective at clearing Plasmodium parasites they do little to protect against CM pathophysiology and parasite-induced brain inflammation that leads to seizures, coma and long-term neurological sequelae in CM patients. Thus, there is urgent need to explore therapeutics that can reduce or prevent CM pathogenesis and associated brain inflammation to improve survival. Neuregulin-1 (NRG-1) is a neurotrophic growth factor shown to protect against brain injury associated with acute ischemic stroke (AIS) and neurotoxin exposure. However, this drug has not been tested against CM-associated brain injury. Since CM-associated brain injuries and AIS share similar pathophysiological features, we hypothesized that NRG-1 will reduce or prevent neuroinflammation and brain damage as well as improve survival in mice with late-stage experimental cerebral malaria (ECM).MethodsWe tested the effects of NRG-1 on ECM-associated brain inflammation and mortality in P. berghei ANKA (PbA)-infected mice and compared to artemether (ARM) treatment; an antimalarial currently used in various combination therapies against malaria.ResultsTreatment with ARM (25 mg/kg/day) effectively cleared parasites and reduced mortality in PbA-infected mice by 82%. Remarkably, NRG-1 therapy (1.25 ng/kg/day) significantly improved survival against ECM by 73% despite increase in parasite burden within NRG-1-treated mice. Additionally, NRG-1 therapy reduced systemic and brain pro-inflammatory factors TNFalpha, IL-6, IL-1alpha and CXCL10 and enhanced anti-inflammatory factors, IL-5 and IL-13 while decreasing leukocyte accumulation in brain microvessels.ConclusionsThis study suggests that NRG-1 attenuates ECM-associated brain inflammation and injuries and may represent a novel supportive therapy for the management of CM

Recent Decisions

Comments on recent decisions by Harry D. Snyder, John A. Vuono, Leonard J. Kamer, John A. Young, Allan C. Schmid, William B. McFadden, David N. McBride, and Thomas J. Griffin