A Deep Chandra Observation of the Distant Galaxy Cluster MS1137.5+6625

We present results from a deep Chandra observation of MS1137.5+66, a distant (z=0.783) and massive cluster of galaxies. Only a few similarly massive clusters are currently known at such high redshifts; accordingly, this observation provides much-needed information on the dynamical state of these rare systems. The cluster appears both regular and symmetric in the X-ray image. However, our analysis of the spectral and spatial X-ray data in conjunction with interferometric Sunyaev-Zel'dovich effect data and published deep optical imaging suggests the cluster has a fairly complex structure. The angular diameter distance we calculate from the Chandra and Sunyaev-Zel'dovich effect data assuming an isothermal, spherically symmetric cluster implies a low value for the Hubble constant for which we explore possible explanations.Comment: 16 pages, 6 figures, submitted to Ap

Amniotic Fluid Glucose Concentration: A Marker for Infection in Preterm Labor and Preterm Premature Rupture of Membranes

Amniotic fluid Gram stain and culture have been utilized as laboratory tests of microbial invasion of the amniotic cavity. The Gram stain of amniotic fluid has a low sensitivity in the detection of clinical infection or microbial invasion of the amniotic cavity, and amniotic fluid culture results are not immediately available for management decisions. Glucose concentration is used to diagnose infection in other sites such as cerebrospinal fluid

Preliminary needs assessment of mobile technology use for healthcare among homeless veterans

Background. Homeless veterans have complex healthcare needs, but experience many barriers to treatment engagement. While information technologies (IT), especially mobile phones, are used to engage patients in care, little is known about homeless veterans\u27 IT use. This study examines homeless veterans\u27 access to and use of IT, attitudes toward health-related IT use, and barriers to IT in the context of homelessness. Methods. Qualitative interviews were conducted with 30 homeless veterans in different housing programs in Boston, MA, ranging from emergency shelters to supportive transitional housing that allow stays of up to 2 years. Interviews were conducted in person, audio recorded and then transcribed. Three researchers coded transcripts. Inductive thematic analysis was used. Results. Most participants (90%) had a mobile phone and were receptive to IT use for health-related communications. A common difficulty communicating with providers was the lack of a stable mailing address. Some participants were using mobile phones to stay in touch with providers. Participants felt mobile-phone calls or text messages could be used to remind patients of appointments, prescription refills, medication taking, and returning for laboratory results. Mobile phone text messaging was seen as convenient, and helped participants stay organized because necessary information was saved in text messages. Some reported concerns about the costs associated with mobile phone use (calls and texting), the potential to be annoyed by too many text messages, and not knowing how to use text messaging. Conclusion. Homeless veterans use IT and welcome its use for health-related purposes. Technology-assisted outreach among this population may lead to improved engagement in care

Nitrate and nitrite contamination in drinking water and cancer risk: A systematic review with meta-analysis

BACKGROUND: Pollution of water sources, largely from wide-scale agricultural fertilizer use has resulted in nitrate and nitrite contamination of drinking water. The effects on human health of raised nitrate and nitrite levels in drinking water are currently unclear. OBJECTIVES: We conducted a systematic review of peer-reviewed literature on the association of nitrate and nitrite in drinking water with human health with a specific focus on cancer. METHODS: We searched eight databases from 1 January 1990 until 28 February 2021. Meta-analyses were conducted when studies had the same exposure metric and outcome. RESULTS: Of 9835 studies identified in the literature search, we found 111 studies reporting health outcomes, 60 of which reported cancer outcomes (38 case-control studies; 12 cohort studies; 10 other study designs). Most studies were set in the USA (24), Europe (20) and Taiwan (14), with only 3 studies from low and middle-income countries. Nitrate exposure in water (59 studies) was more commonly investigated than nitrite exposure (4 studies). Colorectal (15 studies) and gastric (13 studies) cancers were the most reported. In meta-analyses (4 studies) we identified a positive association of nitrate exposure with gastric cancer, OR = 1.91 (95%CI = 1.09-3.33) per 10 mg/L increment in nitrate ion. We found no association of nitrate exposure with colorectal cancer (10 studies; OR = 1.02 [95%CI = 0.96-1.08]) or cancers at any other site. CONCLUSIONS: We identified an association of nitrate in drinking water with gastric cancer but with no other cancer site. There is currently a paucity of robust studies from settings with high levels nitrate pollution in drinking water. Research into this area will be valuable to ascertain the true health burden of nitrate contamination of water and the need for public policies to protect human health

The association between anthropometric measures of adiposity and the progression of carotid atherosclerosis.

BACKGROUND: Few reports are available on the contribution of general and abdominal obesity to the progression of carotid atherosclerosis in late adulthood. This study investigated the impact of four simple anthropometric measures of general and abdominal obesity on the progression of carotid atherosclerosis and the extent to which the association between adiposity and the progression of plaque burden is mediated by cardiometabolic markers. METHODS: Four thousand three hundred forty-five adults (median age 60) from the population-based Tromsø Study were followed over 7 years from the first carotid ultrasound screening to the next. The progression of carotid atherosclerosis was measured in three ways: incidence of plaques in previously plaque-free participants; change in the number of plaques; and total plaque area (TPA). We used generalised linear models to investigate the association between each adiposity measure - body mass index (BMI), waist circumference (WC), waist-to-hip ratio (WHR), and waist-to-height ratio (WHtR) - and each outcome. Models were adjusted for potential confounders (age, sex, smoking, education, physical activity). The pathways through which any associations observed might operate were investigated by further adjusting for cardiometabolic mediators (systolic blood pressure, cholesterol, and HbA1c). RESULTS: There was little evidence that adiposity was related to the formation of new plaques during follow-up. However, abdominal adiposity was associated with TPA progression. WHtR showed the largest effect size (mean change in TPA per one standard deviation (SD) increase in WHtR of 0.665 mm2, 95% confidence interval 0.198, 1.133) while BMI showed the smallest. Effect sizes were substantially reduced after the adjustment for potential mediators. CONCLUSIONS: Abdominal obesity indirectly measured with WC seems more strongly associated with the progression of TPA than general obesity. These associations appear to be largely mediated by known cardiometabolic markers

An Absence of Hot Jupiter Planets in 47 Tucanae: Results of a Wide-Field Transit Search

We present the results of a comprehensive wide field search for transiting ``Hot Jupiter'' planets (1d<P<16d) in the globular cluster 47 Tucanae. Motivated by the core null result of Gilliland and coworkers, this work further addresses the question of giant planet frequency in 47 Tuc by observing, from the ground, a 52'x52' field centered on the cluster for 30.4 nights. Hence this work is most sensitive to the uncrowded outer regions of the cluster and concentrates on 21,920 main sequence stars (~solar in mass). This work comprises the largest ground-based transit search of a globular cluster to date. Monte Carlo simulations predict that seven planets should be present in our dataset, if 47 Tuc has the same planetary frequency observed in the solar neighbourhood. A detailed search with a custom developed detection algorithm found no transit events. Being consistent with the cluster core null detection of Gilliland and coworkers, our result indicates that system metallicity is the dominant effect inhibiting Hot Jupiter formation in this environment.Comment: 27 pages, accepted and 'in press' for Ap

The extended tails of Palomar 5: A ten degree arc of globular cluster tidal debris

Using wide-field photometric data from the Sloan Digital Sky Survey (SDSS) we recently showed that the Galactic globular cluster Palomar 5 is in the process of being tidally disrupted. Its tidal tails were initially detected in a 2.5 degree wide band along the celestial equator. A new analysis of SDSS data for a larger field now reveals that the tails of Pal 5 have a much larger spatial extent and can be traced over an arc of 10 deg across the sky, corresponding to a projected length of 4 kpc at the distance of the cluster. The number of former cluster stars found in the tails adds up to about 1.2 times the number of stars in the cluster. The radial profile of stellar surface density in the tails follows approximately a power law r^gamma with -1.5 < gamma < -1.2. The stream of debris from Pal 5 is significantly curved, which demonstrates its acceleration by the Galactic potential. The cluster is presently near the apocenter but has repeatedly undergone disk crossings in the inner part of the Galaxy leading to strong tidal shocks. Our results suggest that the observed debris originates mostly from mass loss within the last 2 Gyrs. The cluster is likely to be destroyed after the next disk crossing, which will happen in about 100 Myr. (abridged)Comment: 44 pages, including 14 figures (Figs.1,3 & 14 with decreased resolution), accepted for publication in the Astronomical Journa

Fluctuations and Intrinsic Pinning in Layered Superconductors

A flux liquid can condense into a smectic crystal in a pure layered superconductors with the magnetic field oriented nearly parallel to the layers. If the smectic order is commensurate with the layering, this crystal is {\sl stable} to point disorder. By tilting and adjusting the magnitude of the applied field, both incommensurate and tilted smectic and crystalline phases are found. We discuss transport near the second order smectic freezing transition, and show that permeation modes lead to a small non--zero resistivity and large but finite tilt modulus in the smectic crystal.Comment: 4 pages + 1 style file + 1 figure (as uufile) appended, REVTEX 3.

The Tides They are A-Changin\u27: A Comprehensive Review of Past and Future Nonastronomical Changes in Tides, Their Driving Mechanisms, and Future Implications

Scientists and engineers have observed for some time that tidal amplitudes at many locations are shifting considerably due to nonastronomical factors. Here we review comprehensively these important changes in tidal properties, many of which remain poorly understood. Over long geological time scales, tectonic processes drive variations in basin size, depth, and shape and hence the resonant properties of ocean basins. On shorter geological time scales, changes in oceanic tidal properties are dominated by variations in water depth. A growing number of studies have identified widespread, sometimes regionally coherent, positive, and negative trends in tidal constituents and levels during the 19th, 20th, and early 21st centuries. Determining the causes is challenging because a tide measured at a coastal gauge integrates the effects of local, regional, and oceanic changes. Here, we highlight six main factors that can cause changes in measured tidal statistics on local scales and a further eight possible regional/global driving mechanisms. Since only a few studies have combined observations and models, or modeled at a temporal/spatial resolution capable of resolving both ultralocal and large-scale global changes, the individual contributions from local and regional mechanisms remain uncertain. Nonetheless, modeling studies project that sea level rise and climate change will continue to alter tides over the next several centuries, with regionally coherent modes of change caused by alterations to coastal morphology and ice sheet extent. Hence, a better understanding of the causes and consequences of tidal variations is needed to help assess the implications for coastal defense, risk assessment, and ecological change

The Tides They Are A-Changin': A Comprehensive Review of Past and Future Nonastronomical Changes in Tides, Their Driving Mechanisms, and Future Implications:A comprehensive review of past and future non‐astronomical changes in tides, their driving mechanisms and future implications

Scientists and engineers have observed for some time that tidal amplitudes at many locations are shifting considerably due to non-astronomical factors. Here we review comprehensively these important changes in tidal properties, many of which remain poorly understood. Over long geological time-scales, tectonic processes drive variations in basin size, depth, and shape, and hence the resonant properties of ocean basins. On shorter geological time-scales, changes in oceanic tidal properties are dominated by variations in water depth. A growing number of studies have identified widespread, sometimes regionally-coherent, positive and negative trends in tidal constituents and levels during the 19th, 20th and early 21st centuries. Determining the causes is challenging because a tide measured at a coastal gauge integrates the effects of local, regional, and oceanic changes. Here, we highlight six main factors that can cause changes in measured tidal statistics on local scales, and a further eight possible regional/global driving mechanisms. Since only a few studies have combined observations and models, or modelled at a temporal/spatial resolution capable of resolving both ultra-local and large-scale global changes, the individual contributions from local and regional mechanisms remain uncertain. Nonetheless, modelling studies project that sea-level rise and climate change will continue to alter tides over the next several centuries, with regionally coherent modes of change caused by alterations to coastal morphology and ice sheet extent. Hence, a better understanding of the causes and consequences of tidal variations is needed to help assess the implications for coastal defense, risk assessment, and ecological change