Geochemistry and petrogenesis of the East Branch Brook metagabbroic dykes in the Sawyer Brook fault zone, Clarence Stream gold prospect, southwestern New Brunswick

The East Branch Brook (EBB) metagabbroic dykes, host to a portion of the Clarence Stream gold deposit, are situated within the contact metamorphic aureole of the Middle Devonian I-type Magaguadavic Granite on the northwestern margin of the post-orogenic Saint George Bathohth. They are highly deformed, light- (type I), intermediate- (type 2) to dark-coloured (type 3) dykes containing auriferous quartz veins that occupy brittle to ductile northeast-trending shear zones in shallow marine, hornfelsed, volcaniclastic, sedimentary rocks of the Silurian Waweig and Oak Bay formations. The shear zones parallel the regional structure as a result of proximity to the faulted boundary (Sawyer Brook fault) between the Ordovician St. Croix terrane to the northwest and the Silurian to Early Devonian Mascarcne Basin to the southeast. Geochemical studies of the EBB dykes indicate that three pulses (Fe-rich. intermediate, and Mg-rich) of subalkaline to slightly alkaline continental tholeiitc magmas were generated in a transpressional environment during the Early Silurian to Early Devonian Positive εNd values indicate their derivation from a partially depleted mantle source during faulting and nft-related events Although the geochemical data (Fe- and Ti-depletion) indicate calc-alkaline affinity for the nearby Bocabec intrusive complex, εNd values and primitive mantle-normalized spider diagram patterns are similar to those of the EBB dykes. In contrast, the St. Stephen Intrusion appears more primitive with within-plate tholeiitic to slightly alkalie affinity RÉSUMÉ Les dykes metagabbroïques du ruisseau East Branch, qui abritent une partie du gite aurifière dc Clarence Stream, sont situées à l'inténeur de 1'auréolc de métamorphismc de contact du granite du Dévonian moyen de type 1 de Magaguadavic sur la limite nord-ouest du batholithe postorogénique de Saint George. Il s'agit de dykes extrémemeni déformés de teinte pàle (type 1) et intermédiaire (type 2) à foncée (type 3) renfermant des filons de quartz aurifere qui occupent des zones de eisaillement cassantes à déformables, orientées ver\ Ic nord-est. dans des roches sédimcntaires volcanoclastiques à coméenncs marines peu profondes des formations silunennes de Wawcig el d'Oak Bay. La proximilé de la limite faillée (faille du runsseau Sawyer) entre le terrane ordovicien de St. Croix, au nord-ouest et le bassin du Silurien au Dévonien inférieur de Mascarenc. au sud-est, a amené les zones du eisaillement à longer parallélement la structure régionale. Des éludes géochimiques des dykes du ruisseau East Branch révèlent que trois impulsions (composante riche en Fer. composante intermédiaire et composante riche en Mg) de magmas tholéutiques continentaux, allant de subalcalins à légèrement alcalms sont survenues dans un environnement transpressionnel pendant la période du Silurien inferieur au Dévonien infèrieur. Les vateurs positives de εNd lémoignent de leur provenance d'un manteau particllement appauri pendant la formation de failles et des phénomènes apparcntes à une distension Même les données géeochimiques (appaurassement en Fe et en Ti) revèlent unc affinité calcoalcaline du complexe intrusif proche de Bocabec. les valeurs de εNd et les configurations de diagrammes en araignée normalisées du manteau primitif sont analogues a celles des dykes du ruisseau East Branch Par contre, l'intrusion de Saint Stephen semble plus primitive avec une affinite mira-plaques allant de tholénlique à légèrcment alcaline Traduit par la rédactio

Chemostratigraphy and depositional environment of an Ordovician sedimentary section across the Miramichi Group - Tetagouche Group contact, northeastern New Brunswick

A thick section of Ordovician sedimentary rocks underlies and overlies felsic to mafic volcanic rocks of the Tetagouche Group, Bathurst Mining Camp. The dark grey quartzose slates and siltstones of the Patrick Brook Formation (Miramichi Group) occur below the volcanic rocks, whereas the dark grey to black slates and siltstones of the Boucher Brook Formation (Tetagouche Group) are intercalated with the volcanic rocks and overlie the sequence. The Miramichi-Tctagouche contact represents the interpreted Gander-Dunnage boundary in northeastern New Brunswick. Distinguishing between these two simitar formations is important for stratigraphic and geo-tectonic interpretations of the Bathurst Mining Camp and for exploration in these sequences. The geochemical composition of a semi-con form able section of rocks from the Boucher Brook (Middle to Late? Ordovician) and Patrick Brook (Early to Middle Ordovician) formations was determined to identify geochemical chemostratigraphic discriminants, as well as to determine the depositional environment in which these were deposited. The high AI2O3 and distinctly higher high-field-strength elements (LREE, Th, HREE, and Y) in the Patrick Brook rocks are characteristic of mature sedimentary rocks and indicate intense chemical weathering (tropical environment) in the source regions, which is consistent with their compositional similarity to Avalon-derived shales analogous to Gander Zone sedimentary rocks. The Boucher Brook slates and siltstones are immature sedimentary rocks based on the preservation of albite and the less coherent trace-element systematics to phyllosilicate indices (AI2O3 and K2O). The Boucher Brook Formation is probably derived from the associated volcanic rocks. The higher Mn and Fe and positive Ce/Ce* anomaly in some Boucher Brook Formation compared to the Patrick Brook rocks indicate that the Boucher Brook rocks in this section were deposited in a transitional anoxic/ oxic environment. The Patrick Brook rocks that immediately precede felsic volcanism and formation of massive sulphide deposits are highly reduced based on C and S contents, which is consistent with the sulphur isotope data. Moderately heavy δ34S values are indicative of SO42- reduction to H2S under anoxic conditions, which is significant in the formation and preservation of massive sulphides in the basal Tetagouche sequence. RÉSUMÉ Une section épaisse de roches sédimentaires de l’Ordovicien est sus-jacente ct sous-jacente à des roches volcanomafiques à volcanofelsiques du groupe de Tetagouche, dans le Camp minier de Bathurst. Des siltstones et des schistes quartzeux gris foncé de la Formation de Patrick Brook (groupe de Miramichi) sont présents au-dessous des roches volcaniques, tandis que des schistes et des siltstones gris foncé à noirs de la formation de Boucher Brook (groupe de Tetagouche) sont intercales dans les roches volcaniques et recouvrent la séquence. La surface de contact de Miramichi-Tetagouche représente ce qu'on interprèts comme la limite de Gander-Dunnage dans le nord-est du Nouveau-Brunswick. Il est important d'établir une distinction entre ces deux formations semblables pour les interprétations stratigraphiques du Camp minier de Bathurst et pour l'exploration dans ces séquences. On a détermine la composition géochimique d'une section semi-concordante de roches de Boucher Brook (Ordovicien moyen à tardif?) et de Patrick Brook (Ordovicien inférieur à moyen) afin de repérer les discriminants chimiostratigraphiques géochimiques ainsi que pour définir le milieu sédimentaire dans lequel ceux-ci ont été deposes. La quantité prononcée d'Al2O3 et la présence distinctement supérieure d'éléments d'intensité de champ élevée (éléments de terres rares légers, Th, éléments de terres rares lourds et Y) dans les roches de Patrick Brook constituent des traits caractérstiques de roches sédimentaires matures; el les témoignent d'une altération climatique chimique intense (milieu tropical) dans les regions d'origine, ce qui est compatible avec la similarité de leur composition avec les schistes en provenance d'Avalon analogues aux roches sédimentaires de la zone de Gander. Les schistes et les siltstones de Boucher Brook sont des roches sédimentaires immatures basées sur la conservation d'albite et la corrélation d'éléments traces moins cohérents avec les indices de phyllosilicates (AI2O3). La Formation de Boucher Brook provient probabtement de roches volcaniques connexes. La proportion supérieure de Mn et de Fe et l’anomalie positive de Ce/Ce* dans certaines parties de la Formation de Boucher Brook révèlcnt que les roches de Boucher Brook de cette section ont été déposées dans un milieu anoxique / oxique de transition. Les roches de Patrick Brook qui ont immédiatement précedé le volcanisme felsique et la formation de gitcs de sulfures massifs ont, à en juger par Icur teneur en C et en S, subi une réduction importante, ce qui correspond aux données isotopiques relatives au soufre. Les valeurs moyennement prononcées de δ34S temoignent d'une réduction du SO42- en H2S dans des conditions anoxiques, un phénomène déterminant dans la formation et la conservation des sulfures massifs dans la séquence basale de Tetagouche. [Traduit par la rédaction

Precise U-Pb ages for the cogenetic alkaline Mount LaTour and peraluminous Mount Elizabeth granites of the South Nepisiguit River Plutonic Suite, northern New Brunswick, Canada

The South Nepisiguit River Plutonic Suite consists of various phases of felsic to mafic plutonic rocks of early Devonian age in northern New Brunswick. The felsic portion of this intrusive suite includes a large pluton of homogeneous, peraluminous biotite granite (the Mount Elizabeth Granite), which is flanked on its western side by the alkaline Mount LaTour Granite. New in situ and mineral separate U-Pb Laser Ablation-Inductively Coupled Plasma Mass Spectro-metry analyses of monazite and zircon grains from both sides of the suite define a crystallization age of 417.3 ± 0.96 Ma for the Mount Elizabeth Granite and 417.7 ± 4.4 Ma for the Mount LaTour Granite. The new data confirm previous geochronological work and indicate a close temporal relationship between these felsic phases of this plutonic suite

On the Spectroscopic Diversity of Type Ia Supernovae

A comparison of the ratio of the depths of two absorption features in the spectra of TypeIa supernovae (SNe Ia) near the time of maximum brightness with the blueshift of the deep red Si II absorption feature 10 days after maximum shows that the spectroscopic diversity of SNe Ia is multi-dimensional. There is a substantial range of blueshifts at a given value of the depth ratio. We also find that the spectra of a sample of SNe Ia obtained a week before maximum brightness can be arranged in a ``blueshift sequence'' that mimics the time evolution of the pre-maximum-light spectra of an individual SN Ia, the well observed SN 1994D. Within the context of current SN Ia explosion models, we suggest that some of the SNe Ia in our sample were delayed-detonations while others were plain deflagrations.Comment: accepted for publication in ApJ

Quantitative analysis of cell types during growth and morphogenesis in Hydra

Tissue maceration was used to determine the absolute number and the distribution of cell types in Hydra. It was shown that the total number of cells per animal as well as the distribution of cells vary depending on temperature, feeding conditions, and state of growth. During head and foot regeneration and during budding the first detectable change in the cell distribution is an increase in the number of nerve cells at the site of morphogenesis. These results and the finding that nerve cells are most concentrated in the head region, diminishing in density down the body column, are discussed in relation to tissue polarity

Analysis of the Type IIn Supernova 1998S: Effects of Circumstellar Interaction on Observed Spectra

We present spectral analysis of early observations of the Type IIn supernova 1998S using the general non-local thermodynamic equilibrium atmosphere code \tt PHOENIX}. We model both the underlying supernova spectrum and the overlying circumstellar interaction region and produce spectra in good agreement with observations. The early spectra are well fit by lines produced primarily in the circumstellar region itself, and later spectra are due primarily to the supernova ejecta. Intermediate spectra are affected by both regions. A mass-loss rate of order $\dot M \sim 0.0001-0.001$\msol yr$^{-1}$ is inferred for a wind speed of 100-1000 \kmps. We discuss how future self-consistent models will better clarify the underlying progenitor structure.Comment: to appear in ApJ, 2001, 54

Geological relationships and laser ablation ICP-MS U-Pb geochronology of the Saint George Batholith, southwestern New Brunswick, Canada: implications for its tectonomagmatic evolution

  The Late Silurian to Late Devonian Saint George Batholith in southwestern New Brunswick is a large composite intrusion (2000 km2) emplaced into the continental margin of the peri-Gondwanan microcontinent of Ganderia. The batholith includes: (1) Bocabec Gabbro; (2) equigranular Utopia and Wellington Lake biotite granites; (3) Welsford, Jake Lee Mountain, and Parks Brook peralkaline granites; (4) two-mica John Lee Brook Granite; (6) Jimmy Hill and Magaguadavic megacrystic granites; and (6) rapakivi Mount Douglas Granite. New LA ICP-MS in situ analyses of six samples from the Saint George Batholith are as follows: (1) U-Pb monazite crystallization age of 425.5 ± 2.1 Ma for the Utopia Granite in the western part of the batholith (2) U-Pb zircon crystallization ages of 420.4 ± 2.4 Ma and 420.0 ± 3.5 Ma for two samples of the Utopia Granite from the central part of the batholith; (3) U-Pb zircon crystallization age of 418.0 ± 2.3 Ma for the Jake Lee Mountain Granite; (4) U-Pb zircon crystallization age of 415.5 ± 2.1 Ma for the Wellington Lake Granite; and (5) U-Pb monazite crystallization age of 413.3 ± 2.1 Ma for the John Lee Brook Granite. The new geochronological together with new and existing geochemical data suggest that the protracted magmatic evolution of the Late Silurian to Early Devonian plutonic rocks is related to the transition of the Silurian Kingston arc-Mascarene backarc system from an extensional to compressional tectonic environment during collision of the Avalonian microcontinent with Laurentia followed by slab break-off.

Wild-Type and Mutant Hemagglutinin Fusion Peptides Alter Bilayer Structure as Well as Kinetics and Activation Thermodynamics of Stalk and Pore Formation Differently: Mechanistic Implications

Viral fusion peptides are short N-terminal regions of type-1 viral fusion proteins that are critical for virus entry. Although the importance of viral fusion peptides in virus-cell membrane fusion is established, little is known about how they function. We report the effects of wild-type (WT) hemagglutinin (HA) fusion peptide and its G1S, G1V, and W14A mutants on the kinetics of poly(ethylene glycol)(PEG)-mediated fusion of small unilamellar vesicles composed of dioleoylphosphatidylcholine, dioleoylphosphatidylethanolamine, sphingomyelin, and cholesterol (molar ratio of 35:30:15:20). Time courses of lipid mixing, content mixing, and content leakage were obtained using fluorescence assays at multiple temperatures and analyzed globally using either a two-step or three-step sequential ensemble model of the fusion process to obtain the rate constant and activation thermodynamics of each step. We also monitored the influence of peptides on bilayer interfacial order, acyl chain order, bilayer free volume, and water penetration. All these data were considered in terms of a recently published mechanistic model for the thermodynamic transition states for each step of the fusion process. We propose that WT peptide catalyzes Step 1 by occupying bilayer regions vacated by acyl chains that protrude into interbilayer space to form the Step 1 transition state. It also uniquely contributes a positive intrinsic curvature to hemi-fused leaflets to eliminate Step 2 and catalyzes Step 3 by destabilizing the highly stressed edges of the hemi-fused microstructures that dominate the ensemble of the intermediate state directly preceding fusion pore formation. Similar arguments explain the catalytic and inhibitory properties of the mutant peptides and support the hypothesis that the membrane-contacting fusion peptide of HA fusion protein is key to its catalytic activity

Reframing Kurtz’s Painting: Colonial Legacies and Minority Rights in Ethnically Divided Societies

Minority rights constitute some of the most normatively and economically important human rights. Although the political science and legal literatures have proffered a number of constitutional and institutional design solutions to address the protection of minority rights, these solutions are characterized by a noticeable neglect of, and lack of sensitivity to, historical processes. This Article addresses that gap in the literature by developing a causal argument that explains diverging practices of minority rights protections as functions of colonial governments’ variegated institutional practices with respect to particular ethnic groups. Specifically, this Article argues that in instances where colonial governments politicize and institutionalize ethnic hegemony in the pre-independence period, an institutional legacy is created that leads to lower levels of minority rights protections. Conversely, a uniform treatment and depoliticization of ethnicity prior to independence ultimately minimizes ethnic cleavages post-independence and consequently causes higher levels of minority rights protections. Through a highly structured comparative historical analysis of Botswana and Ghana, this Article builds on a new and exciting research agenda that focuses on the role of long-term historio-structural and institutional influences on human rights performance and makes important empirical contributions by eschewing traditional methodologies that focus on single case studies that are largely descriptive in their analyses. Ultimately, this Article highlights both the strength of a historical approach to understanding current variations in minority rights protections and the varied institutional responses within a specific colonial government

In vitro and in vivo evaluation of a single chain antibody fragment generated in planta with potent rabies neutralisation activity.

Rabies causes more than 60,000 human deaths annually in areas where the virus is endemic. Importantly, rabies is one of the few pathogens for which there is no treatment following the onset of clinical disease with the outcome of infection being death in almost 100% of cases. Whilst vaccination, and the combination of vaccine and rabies immunoglobulin treatment for post-exposure administration are available, no tools have been identified that can reduce or prevent rabies virus replication once clinical disease has initiated. The search for effective antiviral molecules to treat those that have already developed clinical disease associated with rabies virus infection is considered one of the most important goals in rabies research. The current study assesses a single chain antibody molecule (ScFv) based on a monoclonal antibody that potently neutralises rabies in vitro as a potential therapeutic candidate. The recombinant ScFv was generated in Nicotiana benthamiana by transient expression, and was chemically conjugated (ScFv/RVG) to a 29 amino acid peptide, specific for nicotinic acetylcholine receptor (nAchR) binding in the CNS. This conjugated molecule was able to bind nAchR in vitro and enter neuronal cells more efficiently than ScFv. The ability of the ScFv/RVG to neutralise virus in vivo was assessed using a staggered administration where the molecule was inoculated either four hours before, two days after or four days after infection. The ScFv/RVG conjugate was evaluated in direct comparison with HRIG and a potential antiviral molecule, Favipiravir (also known as T-705) to indicate whether there was greater bioavailability of the ScFv in the brains of treated mice. The study indicated that the approach taken with the ScFv/RVG conjugate may have utility in the design and implementation of novel tools targetting rabies virus infection in the brain