Number of SNPs used for association testing in each gene.

<p>Number of SNPs used for association testing in each gene.</p

Association results between coffee liking and the two non-synonymous SNPs.

<p>beta represents the coefficient of the linear regression with respect to the wild type allele W for rs68157013 and H for rs71443637 <i>p</i> is the p-value of the association analysis. All populations show concordant effect directions except for INGI-FVG which shows no apparent effect of the alleles on coffee liking.</p

Regional plot of the association results in the <i>TAS2R43</i> gene.

<p>Triangles represent non-synonymous SNPs whereas squares represent synonymous SNPs.. The colors represent the LD between the SNPs and rs71443637 with respect to the 1000 Genomes CEU population. The violet point is the index SNP which the LD refers to. The plot was created with the LocusZoom software <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0092065#pone.0092065-Pruim1" target="_blank">[40]</a>.</p

Forest plot of the normalized effect for the various populations for rs71443637.

<p>Points represent the effect estimates and bars indicate is the 95% confidence interval. The diamond represents the pooled effect. For each population <i>p</i>-values are also shown. INGI-FVG clearly shows no effect of the SNP on coffee liking.</p

Acetate.gwas

Acetate.gwa

Ornithine.gwas

Ornithine.gwa

3-Hydroxybutyrate.gwas

3-Hydroxybutyrate.gwa

Myoinositol.gwas

Myoinositol.gwa

Alpha-ketoglutarate.gwas

Alpha-ketoglutarate.gwa

Proline.gwas

Proline.gwa