1,754 research outputs found
Multiple binding sites for transcriptional repressors can produce regular bursting and enhance noise suppression
Cells may control fluctuations in protein levels by means of negative
autoregulation, where transcription factors bind DNA sites to repress their own
production. Theoretical studies have assumed a single binding site for the
repressor, while in most species it is found that multiple binding sites are
arranged in clusters. We study a stochastic description of negative
autoregulation with multiple binding sites for the repressor. We find that
increasing the number of binding sites induces regular bursting of gene
products. By tuning the threshold for repression, we show that multiple binding
sites can also suppress fluctuations. Our results highlight possible roles for
the presence of multiple binding sites of negative autoregulators
Turing Instability in a Boundary-fed System
The formation of localized structures in the chlorine dioxide-idodine-malonic
acid (CDIMA) reaction-diffusion system is investigated numerically using a
realistic model of this system. We analyze the one-dimensional patterns formed
along the gradients imposed by boundary feeds, and study their linear stability
to symmetry-breaking perturbations (Turing instability) in the plane transverse
to these gradients. We establish that an often-invoked simple local linear
analysis which neglects longitudinal diffusion is inappropriate for predicting
the linear stability of these patterns. Using a fully nonuniform analysis, we
investigate the structure of the patterns formed along the gradients and their
stability to transverse Turing pattern formation as a function of the values of
two control parameters: the malonic acid feed concentration and the size of the
reactor in the dimension along the gradients. The results from this
investigation are compared with existing experiments.Comment: 41 pages, 18 figures, to be published in Physical Review
Effect of Co doping and hydrostatic pressure on SrFe2As2
We report a pressure study on electron doped SrFeCoAs by
electrical-resistivity () and magnetic-susceptibility ()
experiments. Application of either external pressure or Co substitution rapidly
suppresses the spin-density wave ordering of the Fe moments and induces
superconductivity in SrFeAs. At the broad superconducting (SC)
dome in the phase diagram exhibits its maximum K at
a pressure of only GPa. In
SrFeCoAs no superconductivity is observed anymore up to 2.8
GPa. Upon increasing the Co concentration the maximum of the SC dome shifts
toward lower pressure accompanied by a decrease in the value of . Even though, superconductivity is induced by both tuning methods, Co
substitution leads to a much more robust SC state. Our study evidences that in
SrFeCoAs both, the effect of pressure and Co-substitution, have
to be considered in order to understand the SC phase-diagram and further
attests the close relationship of SrFeAs and its sister compound
BaFeAs.Comment: 6 pages, 6 figure
Temperature - pressure phase diagram of CeCoSi: Pressure induced high-temperature phase
We have studied the temperature-pressure phase diagram of CeCoSi by
electrical-resistivity experiments under pressure. Our measurements revealed a
very unusual phase diagram. While at low pressures no dramatic changes and only
a slight shift of the Ne\'{e}l temperature ( K) are observed,
at about 1.45 GPa a sharp and large anomaly, indicative of the opening of a
spin-density-wave (SDW) gap, appears at a comparatively high temperature K. With further increasing pressure shifts rapidly to low
temperatures and disappears at about 2.15 GPa, likely continuously in a quantum
critical point, but without evidence for superconductivity. Even more
surprisingly, we observed a clear shift of to higher temperatures upon
applying a magnetic field. We discuss two possible origins for , either
magnetic ordering of Co or a meta-orbital type of transition of Ce.Comment: 6 pages, 5 figure
Nonlinearity arising from noncooperative transcription factor binding enhances negative feedback and promotes genetic oscillations
We study the effects of multiple binding sites in the promoter of a genetic
oscillator. We evaluate the regulatory function of a promoter with multiple
binding sites in the absence of cooperative binding, and consider different
hypotheses for how the number of bound repressors affects transcription rate.
Effective Hill exponents of the resulting regulatory functions reveal an
increase in the nonlinearity of the feedback with the number of binding sites.
We identify optimal configurations that maximize the nonlinearity of the
feedback. We use a generic model of a biochemical oscillator to show that this
increased nonlinearity is reflected in enhanced oscillations, with larger
amplitudes over wider oscillatory ranges. Although the study is motivated by
genetic oscillations in the zebrafish segmentation clock, our findings may
reveal a general principle for gene regulation.Comment: 11 pages, 8 figure
Avoided ferromagnetic quantum critical point in CeRuPO
CeRuPO is a rare example of a ferromagnetic (FM) Kondo-lattice system.
External pressure suppresses the ordering temperature to zero at about
GPa. Our ac-susceptibility and electrical-resistivity
investigations evidence that the type of magnetic ordering changes from FM to
antiferromagnetic (AFM) at about GPa. Studies in applied
magnetic fields suggest that ferromagnetic and antiferromagnetic correlations
compete for the ground state at , but finally the AFM correlations win.
The change in the magnetic ground-state properties is closely related to the
pressure evolution of the crystalline-electric-field level (CEF) scheme and the
magnetic Ruderman-Kittel-Kasuya-Yosida (RKKY) exchange interaction. The
N\'{e}el temperature disappears abruptly in a first-order-like fashion at
, hinting at the absence of a quantum critical point. This is consistent
with the low-temperature transport properties exhibiting Landau-Fermi-liquid
(LFL) behavior in the whole investigated pressure range up to 7.5 GPa.Comment: 12 figure
Competition of local-moment ferromagnetism and superconductivity in Co-substituted EuFe2As2
In contrast to SrFe2As2, where only the iron possesses a magnetic moment, in
EuFe2As2 an additional large, local magnetic moment is carried by Eu2+. Like
SrFe2As2, EuFe2As2 exhibits a spin-density wave transition at high
temperatures, but in addition the magnetic moments of the Eu2+ order at around
20 K. The interplay of pressure-induced superconductivity and the Eu2+ order
leads to a behavior which is reminiscent of re-entrant superconductivity as it
was observed, for example, in the ternary Chevrel phases or in the rare-earth
nickel borocarbides. Here, we study the delicate interplay of the ordering of
the Eu2+ moments and superconductivity in EuFe1.9Co0.1As2, where application of
external pressure makes it possible to sensitively tune the ratio of the
magnetic (T_C) and the superconducting (T_{c,onset}) critical temperatures. We
find that superconductivity disappears once T_C > T_{c,onset}.Comment: 4 pages, 4 figures, submitted to the proceedings of SCES201
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