8 research outputs found

    Restoration of mesenchymal retinal pigmented epithelial cells by TGFβ pathway inhibitors: implications for age-related macular degeneration

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    Envisioning the future with \u27compassionate conservation\u27: An ominous projection for native wildlife and biodiversity

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    The ‘Compassionate Conservation’ movement is gaining momentum through its promotion of ‘ethical’ conservation practices based on self-proclaimed principles of ‘first-do-no-harm’ and ‘individuals matter’. We argue that the tenets of ‘Compassionate Conservation’ are ideological - that is, they are not scientifically proven to improve conservation outcomes, yet are critical of the current methods that do. In this paper we envision a future with ‘Compassionate Conservation’ and predict how this might affect global biodiversity conservation. Taken literally, ‘Compassionate Conservation’ will deny current conservation practices such as captive breeding, introduced species control, biocontrol, conservation fencing, translocation, contraception, disease control and genetic introgression. Five mainstream conservation practices are used to illustrate the far-reaching and dire consequences for global biodiversity if governed by ‘Compassionate Conservation’. We acknowledge the important role of animal welfare science in conservation practices but argue that ‘Compassionate Conservation’ aligns more closely with animal liberation principles protecting individuals over populations. Ultimately we fear that a world of ‘Compassionate Conservation’ could stymie the global conservation efforts required to meet international biodiversity targets derived from evidenced based practice, such as the Aichi targets developed by the Convention on Biological Diversity and adopted by the International Union for the Conservation of Nature and the United Nations

    Reintroducing rewilding to restoration – Rejecting the search for novelty

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    Rewilding is emerging as a major issue in conservation. However, there are currently a dozen definitions of rewilding that include Pleistocene rewilding, island rewilding, trophic rewilding, functional rewilding and passive rewilding, and these remain fuzzy, lack clarity and, hence, hinder scientific discourse. Based on current definitions, it is unclear how the interventions described under the rewilding umbrella differ from those framed within the long-standing term ‘restoration’. Even projects held up as iconic rewilding endeavours invariably began as restoration projects (e.g., Oostvaaderplassen; Pleistocene Park; the return of wolves to Yellowstone, etc.). Similarly, rewilding organisations (e.g., Rewilding Europe) typically began with a restoration focus. Scientific discourse requires precise language. The fuzziness of existing definitions of rewilding and lack of distinction from restoration practices means that scientific messages cannot be transferred accurately to a policy or practice framework. We suggest that the utility of ‘rewilding’ as a term is obsolete, and hence recommend scientists and practitioners use ‘restoration’ instead

    Use of Handheld Computers in Medical Education: A Systematic Review

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    BACKGROUND: Over the past decade, handheld computers (or personal digital assistants [PDAs]) have become a popular tool among medical trainees and physicians. Few comprehensive reviews of PDA use in medicine have been published. OBJECTIVE: We systematically reviewed the literature to (1) describe medical trainees' use of PDAs for education or patient care, (2) catalog popular software applications, and (3) evaluate the impact of PDA use on patient care. DATA SOURCES: MEDLINE (1993 to 2004), medical education-related conference proceedings, and hand search of article bibliographies. REVIEW METHODS: We identified articles and abstracts that described the use of PDAs in medical education by trainees or educators. Reports presenting a qualitative or quantitative evaluation were included. RESULTS: Sixty-seven studies met inclusion criteria. Approximately 60% to 70% of medical students and residents use PDAs for educational purposes or patient care. Satisfaction was generally high and correlated with the level of handheld computer experience. Most of the studies included described PDA use for patient tracking and documentation. By contrast, trainees rated medical textbooks, medication references, and medical calculators as the most useful applications. Only 1 randomized trial with educational outcomes was found, demonstrating improved learning and application of evidence-based medicine with use of PDA-based decision support software. No articles reported the impact of PDA use on patient outcomes. CONCLUSION: Most medical trainees find handhelds useful in their medical education and patient care. Further studies are needed to evaluate how PDAs impact learning and clinical outcomes

    Deconstructing fibrosis research: do pro-fibrotic signals point the way for chronic dermal wound regeneration?

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    Chronic wounds are characterized by inadequate matrix synthesis, no re-epithelialization, infection and ultimately no wound resolution. In contrast, fibrosis is characterized by overproduction of matrix and excess matrix contraction. As research in the fields of chronic wounds and fibrosis surges forward, important parallels can now be drawn between the dysfunctions in fibrotic diseases and the needs of chronic wounds. These parallels exist at both the macroscopic level and at the molecular level. Thus in finding the individual factors responsible for the progression of fibrotic diseases, we may identify new therapeutic targets for the resolution of chronic wounds. The aim of this review is to discuss how recent advances in fibrosis research have found a home in the treatment of chronic wounds and to highlight the benefits that can be obtained for chronic wound treatments by employing a translational approach to molecules identified in fibrosis research
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