Создание синтетического аналога интерлейкина-4

Целью исследовательской работы является описание методики создания синтетическогоаналога человеческого интерлейкина- 4, который будет использован для нанесения на поверхность биоматериалов на основе биодеградируемых полимеров с целью придания иммуномодулирующих свойств и увеличения биосовместимости

Плазмохимический синтез и исследование оксидных композиций из водно-органических нитратных растворов самария, церия и магния

Будут определены составы смешанных водно-органических нитратных растворов самария, церия и магния, а также режимы их переработки в воздушной плазме, обеспечивающие плазмохимический синтез в воздушной плазме сложных наноразмерных оксидных композиций различного состава. Осуществлен плазмохимический синтез оксидных композиций в воздушно-плазменном потоке из диспергированных растворов ВОНР (водно органических нитратных растворов) и исследованы их физико-химические свойства. Установлены закономерности влияния массовой доли матрицы (оксид магния) на площадь удельной поверхности и размер получаемых оксидных композиций.The compositions of mixed water-organic nitrate solutions of samarium, cerium and magnesium will be determined, as well as the modes of their processing in air plasma, which provide plasma-chemical synthesis in air plasma of complex nanoscale oxide compositions of various compositions. Plasma-chemical synthesis of oxide compositions in an air-plasma stream from dispersed solutions of WONS (water-organic nitrate solutions) was carried out and their physical and chemical properties were studied. The regularities of the influence of the mass fraction of the matrix (magnesium oxide) on the specific surface area and the size of the resulting oxide compositions are established

Comparison of strategies to reduce meticillin-resistant Staphylococcus aureus rates in surgical patients: a controlled multicentre intervention trial.

Objective: To compare the effect of two strategies (enhanced hand hygiene vs meticillin-resistant Staphylococcus aureus (MRSA) screening and decolonisation) alone and in combination on MRSA rates in surgical wards. Design: Prospective, controlled, interventional cohort study, with 6-month baseline, 12-month intervention and 6-month washout phases. Setting: 33 surgical wards of 10 hospitals in nine countries in Europe and Israel. Participants: All patients admitted to the enrolled wards for more than 24 h. Interventions: The two strategies compared were (1) enhanced hand hygiene promotion and (2) universal MRSA screening with contact precautions and decolonisation (intranasal mupirocin and chlorhexidine bathing) of MRSA carriers. Four hospitals were assigned to each intervention and two hospitals combined both strategies, using targeted MRSA screening. Outcome measures: Monthly rates of MRSA clinical cultures per 100 susceptible patients (primary outcome) and MRSA infections per 100 admissions (secondary outcome). Planned subgroup analysis for clean surgery wards was performed. Results: After adjusting for clustering and potential confounders, neither strategy when used alone was associated with significant changes in MRSA rates. Combining both strategies was associated with a reduction in the rate of MRSA clinical cultures of 12% per month (adjusted incidence rate ratios (aIRR) 0.88, 95% CI 0.79 to 0.98). In clean surgery wards, strategy 2 (MRSA screening, contact precautions and decolonisation) was associated with decreasing rates of MRSA clinical cultures (15% monthly decrease, aIRR 0.85, 95% CI 0.74 to 0.97) and MRSA infections (17% monthly decrease, aIRR 0.83, 95% CI 0.69 to 0.99). Conclusions: In surgical wards with relatively low MRSA prevalence, a combination of enhanced standard and MRSA-specific infection control approaches was required to reduce MRSA rates. Implementation of single interventions was not effective, except in clean surgery wards where MRSA screening coupled with contact precautions and decolonisation was associated with significant reductions in MRSA clinical culture and infection rates. Trial registration clinicaltrials.gov identifier: NCT0068586

Screening and contact precautions - A survey on infection control measures for multidrug-resistant bacteria in German university hospitals

To assess the scope of infection control measures for multidrug-resistant bacteria in high-risk settings, a survey among university hospitals was conducted. Fourteen professionals from 8 sites participated. Reported policies varied largely with respect to the types of wards conducting screening, sample types used for screening and implementation of contact precautions. This variability among sites highlights the need for an evidence-based consensus of current infection control policies