New technologies of haloaerosoltherapy at asthmatic patients

Speleotherapy - is the method of treatment in conditions of mines and karst caves microclimate. At 40-50-th this method have begun to develop in Germany, Austria and Italy. Later at the 60-th years speleotherapy was put in to practice in East Europe (Poland, Hungary, Slovakia, Romania). The high efficiency of this method of treatment at bronchial asthma (BA) patients is proved

THE USAGE OF HALOAEROSOLOTHERAPY IN THE REHABILITATIONAL TREATMENT OF CHILDREN WITH RECCURENT BRONCHITIS

Aim. Comparative evaluation of the effectiveness of various therapeutic complexes on the basis of haloaerosoltherapy in the rehabilitational treatment of children with recurrent bronchitis on the ground of clinical and functional data and further development of recommendations for differentiated treatment. Objectives. Children (at the age of 6-10 years) with recurrent bronchitis, who received treatment in conditions of artificial rock salt aerosol medium (haloaerosoltherapy). Material and Methods. 35 children with recurrent bronchitis (RB) were examined. All children’s clinical data were monitored; respiratory function was evaluated using spirography. Forced inspiratory vital capacity (FIVC), forced expiratory volume for the 1-st second (FEV1), peak expiratory flow (PEF), forced expiratory flow at the point of 25% from FIVC(FEF25), forced expiratory flow at the point of 50% from FIVC (FEF50), and forced expiratory flow at the point of 75% from FIVC (FEF75) were defined. The patients were treated with the help of two therapeutic complexes (TC). 12 children were treated by the first TC which included haloaerosoltherapy (14 procedures), in well-equipped room with the initial concentration of rock salt aerosol 40 mg/m3 and the predominance of fine powder fraction (<80%). The first procedure lasted 10 minutes, the second – 20 minutes, the third and the following ones – 30 minutes. The concentration and dispersity of haloaerosol were measured with the help of special laser optical system. 23 children underwent second TC, which included 12 procedures of singlet oxygen therapy in the form of foam additionally to the haloaerosoltherapy sessions. Results. At the beginning of the treatment children had no signs of the acute phase of the disease. Though there were some symptoms which testify that the inflammatory process and functional recovery are not finished yet after the acute phase of the recurrent bronchitis. The clinical picture was confirmed by the major indices of respiratory function (RF). It should be noted that several indices which characterize the bronchial permeability, especially small ones were lowered. After treatment clinical symptoms in the majority of patients were normalized. At the same time, some peculiarities of the effectiveness of the treatment were revealed at patients treated using different TCs. The positive dynamics of clinical signs of the disease was also testified by the valuable growth of RF indices. It has to be noted that there was no distinct difference between groups in the RF outcoming data. But TC-2 usage has led to statistically better improvement of integral indices and indices which characterize the bronchial permeability

Long-term safety and efficacy of benralizumab in patients with severe, uncontrolled asthma: 1-year results from the BORA phase 3 extension trial

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