Expected result of firing an ICE load on Z without vacuum.

In addressing the issue of the determining the hazard categorization of the Z Accelerator of doing Special Nuclear Material (SNM) experiments the question arose as to whether the machine could be fired with its central vacuum chamber open, thus providing a path for airborne release of SNM materials. In this report we summarize calculations that show that we could only expect a maximum current of 460 kA into such a load in a long-pulse mode, which will be used for the SNM experiments, and 750 kA in a short-pulse mode, which is not useful for these experiments. We also investigated the effect of the current for both cases and found that for neither case is the current high enough to either melt or vaporize these loads, with a melt threshold of 1.6 MA. Therefore, a necessary condition to melt, vaporize, or otherwise disperse SNM material is that a vacuum must exist in the Z vacuum chamber. Thus the vacuum chamber serves as a passive feature that prevents any airborne release during the shot, regardless of whatever containment may be in place

Dust in Spiral Galaxies: Comparing Emission and Absorption to Constrain Small-Scale and Very Cold Structures

The detailed distribution of dust in the disks of spiral galaxies is important to understanding the radiative transfer within disks, and to measuring overall dust masses if significant quantities of dust are either very opaque or very cold. We address this issue by comparing measures of dust absorption, using the galaxy-overlap technique in the optical, with measures of the dust grains' thermal emission from 50-2000 micron using ISOPHOT on board ISO and SCUBA at the JCMT. We examine three spiral galaxies projected partially in front of E/S0 galaxies --- AM1316-241, NGC 5545, and NGC 5091 (for NGC 5091 we have only optical and ISO data). Adopting an empirical exponential model for the dust distribution, we compare column densities and dust masses derived from the absorption and emission techniques. This comparison is sensitive to the amount of dust mass in small, opaque structures, which would not contribute strongly to area-weighted absorption measures, and to very cold dust, which would contribute to optical absorption but provide only a small fraction of the sub-mm emission. In AM1316-241, we find global dust masses of 2-5 x 10^7 M_solar, both techniques agreeing at the 50% level. NGC 5545 has about half this dust mass. The concordance of dust masses is well within the errors expected from our knowledge of the radial distribution of dust, and argues against any dominant part of the dust mass being so cold or opaque. The 50-2000 micron data are well fitted by modified Planck functions with an emissivity law beta=-2, at 21 +/- 2 K. We also present 12 micron ISOCAM observations of these pairs.Comparison of H-alpha and 12 micron images of NGC 5545 indicate that ISOCAM images are reliable tracers of star formation.Comment: 16 pages, 4 tables, 8 figures, in press for October Astronomical Journa

Finishing the euchromatic sequence of the human genome

The sequence of the human genome encodes the genetic instructions for human physiology, as well as rich information about human evolution. In 2001, the International Human Genome Sequencing Consortium reported a draft sequence of the euchromatic portion of the human genome. Since then, the international collaboration has worked to convert this draft into a genome sequence with high accuracy and nearly complete coverage. Here, we report the result of this finishing process. The current genome sequence (Build 35) contains 2.85 billion nucleotides interrupted by only 341 gaps. It covers ∼99% of the euchromatic genome and is accurate to an error rate of ∼1 event per 100,000 bases. Many of the remaining euchromatic gaps are associated with segmental duplications and will require focused work with new methods. The near-complete sequence, the first for a vertebrate, greatly improves the precision of biological analyses of the human genome including studies of gene number, birth and death. Notably, the human enome seems to encode only 20,000-25,000 protein-coding genes. The genome sequence reported here should serve as a firm foundation for biomedical research in the decades ahead

Correction to: Cluster identification, selection, and description in Cluster randomized crossover trials: the PREP-IT trials

An amendment to this paper has been published and can be accessed via the original article

Factors Associated with Revision Surgery after Internal Fixation of Hip Fractures

Background: Femoral neck fractures are associated with high rates of revision surgery after management with internal fixation. Using data from the Fixation using Alternative Implants for the Treatment of Hip fractures (FAITH) trial evaluating methods of internal fixation in patients with femoral neck fractures, we investigated associations between baseline and surgical factors and the need for revision surgery to promote healing, relieve pain, treat infection or improve function over 24 months postsurgery. Additionally, we investigated factors associated with (1) hardware removal and (2) implant exchange from cancellous screws (CS) or sliding hip screw (SHS) to total hip arthroplasty, hemiarthroplasty, or another internal fixation device. Methods: We identified 15 potential factors a priori that may be associated with revision surgery, 7 with hardware removal, and 14 with implant exchange. We used multivariable Cox proportional hazards analyses in our investigation. Results: Factors associated with increased risk of revision surgery included: female sex, [hazard ratio (HR) 1.79, 95% confidence interval (CI) 1.25-2.50; P = 0.001], higher body mass index (fo

Expected result of firing an ICE load on Z without vacuum.

In addressing the issue of the determining the hazard categorization of the Z Accelerator of doing Special Nuclear Material (SNM) experiments the question arose as to whether the machine could be fired with its central vacuum chamber open, thus providing a path for airborne release of SNM materials. In this report we summarize calculations that show that we could only expect a maximum current of 460 kA into such a load in a long-pulse mode, which will be used for the SNM experiments, and 750 kA in a short-pulse mode, which is not useful for these experiments. We also investigated the effect of the current for both cases and found that for neither case is the current high enough to either melt or vaporize these loads, with a melt threshold of 1.6 MA. Therefore, a necessary condition to melt, vaporize, or otherwise disperse SNM material is that a vacuum must exist in the Z vacuum chamber. Thus the vacuum chamber serves as a passive feature that prevents any airborne release during the shot, regardless of whatever containment may be in place

Expected result of firing an ICE load on Z without vacuum.

In addressing the issue of the determining the hazard categorization of the Z Accelerator of doing Special Nuclear Material (SNM) experiments the question arose as to whether the machine could be fired with its central vacuum chamber open, thus providing a path for airborne release of SNM materials. In this report we summarize calculations that show that we could only expect a maximum current of 460 kA into such a load in a long-pulse mode, which will be used for the SNM experiments, and 750 kA in a short-pulse mode, which is not useful for these experiments. We also investigated the effect of the current for both cases and found that for neither case is the current high enough to either melt or vaporize these loads, with a melt threshold of 1.6 MA. Therefore, a necessary condition to melt, vaporize, or otherwise disperse SNM material is that a vacuum must exist in the Z vacuum chamber. Thus the vacuum chamber serves as a passive feature that prevents any airborne release during the shot, regardless of whatever containment may be in place