Moyo Vol. VII N 1

Durica, Paul. Editor\u27s Letter . 4 Lemke, Angelica. Paxil, Effexor, and Prozac, Oh My! Is Depression Awareness Day Going Too Far? 5. Frey, Randall. Just Be: How to Make Money Without Really Doing Anything . 6. Purks, Robert. 007, Missing The Action. Dalton\u27s Bond Reconsidered . 7. Stine, Alison. Hatching A masterpiece: Jeffery Hatcher Talks of Writing, Melville, Woody Allen, and Denison . 8. Levine, Robert. Dial DU For Murder: Cinema Student Shuffles Off The Mortal Coil, and Finds it an Acquired Taste . 13. Almirall, Sarah. Dial DU For Murder: Cinema Student Shuffles Off The Mortal Coil, and Finds it an Acquired Taste, Photographs . 13. Werne, Kirsten. Back in the Day (Mom and Pop Alums Reflect on the Sixties Social Scene) . 18. Kohlbecker, Matthew. Between a Rock and a Hard Place (A Geological Excursion Into the Wilds of Canada) . 20. Lammont, Jean. Where\u27s Waldon? Comments on the Homestead . 21. Frey, Randall. Me Experimenting with Berry Beer . 25. Frey, Randall. Shoes for Mr. Jordan . 28. Porcheddu, Fred. My Late Adolescence . 30. Combe, Clayton. The Modern Guinea Pig . 31

Finishing the euchromatic sequence of the human genome

The sequence of the human genome encodes the genetic instructions for human physiology, as well as rich information about human evolution. In 2001, the International Human Genome Sequencing Consortium reported a draft sequence of the euchromatic portion of the human genome. Since then, the international collaboration has worked to convert this draft into a genome sequence with high accuracy and nearly complete coverage. Here, we report the result of this finishing process. The current genome sequence (Build 35) contains 2.85 billion nucleotides interrupted by only 341 gaps. It covers ∼99% of the euchromatic genome and is accurate to an error rate of ∼1 event per 100,000 bases. Many of the remaining euchromatic gaps are associated with segmental duplications and will require focused work with new methods. The near-complete sequence, the first for a vertebrate, greatly improves the precision of biological analyses of the human genome including studies of gene number, birth and death. Notably, the human enome seems to encode only 20,000-25,000 protein-coding genes. The genome sequence reported here should serve as a firm foundation for biomedical research in the decades ahead

Association of Genomic Domains in BRCA1 and BRCA2 with Prostate Cancer Risk and Aggressiveness

Pathogenic sequence variants (PSV) in BRCA1 or BRCA2 (BRCA1/2) are associated with increased risk and severity of prostate cancer. We evaluated whether PSVs in BRCA1/2 were associated with risk of overall prostate cancer or high grade (Gleason 8þ) prostate cancer using an international sample of 65 BRCA1 and 171 BRCA2 male PSV carriers with prostate cancer, and 3,388 BRCA1 and 2,880 BRCA2 male PSV carriers without prostate cancer. PSVs in the 3 0 region of BRCA2 (c.7914þ) were significantly associated with elevated risk of prostate cancer compared with reference bin c.1001c.7913 [HR ¼ 1.78; 95% confidence interval (CI), 1.25–2.52; P ¼ 0.001], as well as elevated risk of Gleason 8þ prostate cancer (HR ¼ 3.11; 95% CI, 1.63–5.95; P ¼ 0.001). c.756-c.1000 was also associated with elevated prostate cancer risk (HR ¼ 2.83; 95% CI, 1.71–4.68; P ¼ 0.00004) and elevated risk of Gleason 8þ prostate cancer (HR ¼ 4.95; 95% CI, 2.12–11.54; P ¼ 0.0002). No genotype–phenotype associations were detected for PSVs in BRCA1. These results demonstrate that specific BRCA2 PSVs may be associated with elevated risk of developing aggressive prostate cancer