Change Point Estimation of Bilevel Functions

Reconstruction of a bilevel function such as a bar code signal in a partially blind deconvolution problem is an important task in industrial processes. Existing methods are based on either the local approach or the regularization approach with a total variation penalty. This article reformulated the problem explicitly in terms of change points of the 0-1 step function. The bilevel function is then reconstructed by solving the nonlinear least squares problem subject to linear inequality constraints, with starting values provided by the local extremas of the derivative of the convolved signal from discrete noisy data. Simulation results show a considerable improvement of the quality of the bilevel function using the proposed hybrid approach over the local approach. The hybrid approach extends the workable range of the standard deviation of the Gaussian kernel significantly

Incremental Collaborative Beam Alignment for Millimeter Wave Cell-Free MIMO Systems

Millimeter wave (mmWave) cell-free MIMO achieves an extremely high rate while its beam alignment (BA) suffers from excessive overhead due to a large number of transceivers. Recently, user location and probing measurements are utilized for BA based on machine learning (ML) models, e.g., deep neural network (DNN). However, most of these ML models are centralized with high communication and computational overhead and give no specific consideration to practical issues, e.g., limited training data and real-time model updates. In this paper, we study the {probing} beam-based BA for mmWave cell-free MIMO downlink with the help of broad learning (BL). For channels without and with uplink-downlink reciprocity, we propose the user-side and base station (BS)-side BL-aided incremental collaborative BA approaches. Via transforming the centralized BL into a distributed learning with data and feature splitting respectively, the user-side and BS-side schemes realize implicit sharing of multiple user data and multiple BS features. Simulations confirm that the user-side scheme is applicable to fast time-varying and/or non-stationary channels, while the BS-side scheme is suitable for systems with low-bandwidth fronthaul links and a central unit with limited computing power. The advantages of proposed schemes are also demonstrated compared to traditional and DNN-aided BA schemes.Comment: 15 pages, 15 figures, to appear in the IEEE Transactions on Communications, 202

Hydrodynamics and heat transfer of suspended surface in a supercritical cfb furnace

With the scaling-up of CFB boilers, more heating surfaces like suspended surfaces and/or mid-partition walls, are arranged in the furnace to ensure adequate heat absorption. The length of suspended surface reaches almost half height of the furnace in the Baima 600MW supercritical CFB boiler. Since the gas-solids hydrodynamics and heat transfer on those surfaces are different from that on waterwall, further researches are needed to investigate the characteristics of hydrodynamics and heat transfer on the suspended surfaces. Beside the experimental measurements on the suspended surfaces in a scale down test rig, the hydrodynamic characteristics on the suspended surfaces were computed by a CFD simulation combined with EMMS model in a supercritical CFB of annular furnace. The results present an uneven axial solid concentration profile on the suspended surface, and descending particles are found on some locations especially where those surfaces far away from the furnace exits. Based on the gas-solids hydrodynamic results, the modified cluster renewal model was applied in the heat transfer coefficient calculation of the suspended surfaces. The result shows the heat transfer coefficient varies with the height and it has difference between two sides of a surface. In addition, the average heat transfer coefficients of suspended surface at different locations are compared. References Basu P, Nag P K. Heat transfer to walls of a circulating fluidized-bed furnace[J]. Chemical Engineering Science, 1996, 51(1): 1-26. Cen K F, Ni M J, Luo Z Y, et al. Theoretical design and operation of circulating fluidized bed boiler[J]. China Electric Power Press, Beijing, 1998: 647-663. Cheng L M, Wang Q H, Shi Z L, et al. Heat transfer in a large circulating fluidized bed boiler[J]. Journal of Power Engineering, 2006, 26(3): 305-310. Huang C, Cheng L M, Zhou X L, et al. Suspended surface heat transfer in a large circulating fluidized bed boiler furnace[J]. Journal of Zhejiang University. Engineering Science, 2012, 46(11): 2128-2132. Sundaresan R, Kolar A K. Axial heat transfer correlations in a circulating fluidized bed riser[J]. Applied Thermal Engineering, 2012. * “Strategic Priority Research Program” of the Chinese Academy of Sciences, Grant No. XDA0703010

Shifting from Population-wide to Personalized Cancer Prognosis with Microarrays

The era of personalized medicine for cancer therapeutics has taken an important step forward in making accurate prognoses for individual patients with the adoption of high-throughput microarray technology. However, microarray technology in cancer diagnosis or prognosis has been primarily used for the statistical evaluation of patient populations, and thus excludes inter-individual variability and patient-specific predictions. Here we propose a metric called clinical confidence that serves as a measure of prognostic reliability to facilitate the shift from population-wide to personalized cancer prognosis using microarray-based predictive models. The performance of sample-based models predicted with different clinical confidences was evaluated and compared systematically using three large clinical datasets studying the following cancers: breast cancer, multiple myeloma, and neuroblastoma. Survival curves for patients, with different confidences, were also delineated. The results show that the clinical confidence metric separates patients with different prediction accuracies and survival times. Samples with high clinical confidence were likely to have accurate prognoses from predictive models. Moreover, patients with high clinical confidence would be expected to live for a notably longer or shorter time if their prognosis was good or grim based on the models, respectively. We conclude that clinical confidence could serve as a beneficial metric for personalized cancer prognosis prediction utilizing microarrays. Ascribing a confidence level to prognosis with the clinical confidence metric provides the clinician an objective, personalized basis for decisions, such as choosing the severity of the treatment

Discovery of Molecular Mechanisms of Traditional Chinese Medicinal Formula Si-Wu-Tang Using Gene Expression Microarray and Connectivity Map

To pursue a systematic approach to discovery of mechanisms of action of traditional Chinese medicine (TCM), we used microarrays, bioinformatics and the “Connectivity Map” (CMAP) to examine TCM-induced changes in gene expression. We demonstrated that this approach can be used to elucidate new molecular targets using a model TCM herbal formula Si-Wu-Tang (SWT) which is widely used for women's health. The human breast cancer MCF-7 cells treated with 0.1 µM estradiol or 2.56 mg/ml of SWT showed dramatic gene expression changes, while no significant change was detected for ferulic acid, a known bioactive compound of SWT. Pathway analysis using differentially expressed genes related to the treatment effect identified that expression of genes in the nuclear factor erythroid 2-related factor 2 (Nrf2) cytoprotective pathway was most significantly affected by SWT, but not by estradiol or ferulic acid. The Nrf2-regulated genes HMOX1, GCLC, GCLM, SLC7A11 and NQO1 were upreguated by SWT in a dose-dependent manner, which was validated by real-time RT-PCR. Consistently, treatment with SWT and its four herbal ingredients resulted in an increased antioxidant response element (ARE)-luciferase reporter activity in MCF-7 and HEK293 cells. Furthermore, the gene expression profile of differentially expressed genes related to SWT treatment was used to compare with those of 1,309 compounds in the CMAP database. The CMAP profiles of estradiol-treated MCF-7 cells showed an excellent match with SWT treatment, consistent with SWT's widely claimed use for women's diseases and indicating a phytoestrogenic effect. The CMAP profiles of chemopreventive agents withaferin A and resveratrol also showed high similarity to the profiles of SWT. This study identified SWT as an Nrf2 activator and phytoestrogen, suggesting its use as a nontoxic chemopreventive agent, and demonstrated the feasibility of combining microarray gene expression profiling with CMAP mining to discover mechanisms of actions and to identify new health benefits of TCMs

THE "CHINESE EXPERIENCE" IN RESPONDING TO THE GLOBAL FINANCIAL AND ECONOMIC CRISIS

Even though China has felt the tremendous impact of the financial and economic crisis, it does not fall into such crises itself. The "Chinese Experience" in responding to the international financial and economic crisis indicates that it is necessary for developing socialist countries to constantly consolidate and improve their basic socialist economic system, to strengthen macroeconomic regulation and to scientifically transform and upgrade the mode of economic development. </p

Change Point Estimation of Bi-Level Functions,” To Appear

Reconstruction of a bilevel function such as a bar code signal in a partially blind deconvolution problem is an important task in industrial processes. Existing methods are based on either the local approach or the regularization approach with a total variation penalty. This article reformulated the problem explicitly in terms of change points of the 0-1 step function. The bilevel function is then reconstructed by solving the nonlinear least squares problem subject to linear inequality constraints, with starting values provided by the local extremas of the derivative of the convolved signal from discrete noisy data. Simulation results show a considerable improvement of the quality of the bilevel function using the proposed hybrid approach over the local approach. The hybrid approach extends the workable range of the standard deviation of the Gaussian kernel significantly. Key words: Bar code, 0-1 step function, nonlinear least squares, constrained optimizatio

Change Point Estimation of Bar Code Signals

Existing methods for bar code signal reconstruction is based on either the local approach or the regularization approach with total variation penalty. We formulate the problem explicitly in terms of change points of the 0-1 step function. The bar code is then reconstructed by solving the nonlinear least squares problem subject to linear inequality constraints, with starting values provided by the local extremas of the derivative of the convolved signal from discrete noisy data. Simulation results show a considerable improvement of the quality of the bar code signal using the proposed hybrid approach over the local approach. EDICS Category:IMD-ANAL, SAS-SYST I

Bed inventory balance and stability of dual circulating fluidized bed systems

Experiments and modelling are conducted for general understanding on the imbalance phenomenon and for discussion on the strategies to improve the bed inventory balance and stability of a dual circulating fluidized bed (DCFB) system. The experiments are carried out in a 15.5 m high pilot-scale DCFB cold test system. A fluid-dynamic DCFB model is developed based on a 1.5-dimensional semi-empirical model of an industrial CFB boiler, validated by experimental data. The effects of control methods and operation conditions on the bed inventory balance and on the stability of the pilot- and large-scale DCFB systems are discussed. A “stable-unbalanced” state, where the system reaches a steady state, consisting of unbalanced bed inventories, is observed in both experiments and model simulation. To maintain a balanced state and similar bed inventory in the DCFB systems with similar cross-sectional areas, it is recommended to keep similar total pressure drops or gas velocities in both reactors

Effect of Connection Resistance between Cyclones and Backpass on Furnace Solids Suspension Density Profile and Circulation Rates in CFB

The connection section between cyclones and backpass is an important configuration in multi-cyclone circulating fluidized bed boilers (CFB). In this work, the resistance coefficient of different connection modes, and connection resistance distribution from each cyclone outlet to backpass (connection branch) in one mode are defined and calculated, in order to investigate their effects on furnace solids suspension density distribution and circulation rates. Three connection modes with different overall resistance coefficients were tested experimentally and analyzed by a 1.5-dimensional model in a four-cyclone scaling CFB apparatus. Both experimental and theoretical results show that, with larger overall resistance of a connection, there are more solids suspended in the furnace bottom and fewer in the top section. The investigation of the C-type connection has revealed that when the branch resistance of the connection decreases from branch No. 1–4, the solids suspension density and circulation rate from corresponding solids recycle loops (No. 1–4) increase. Moreover, the non-uniformity of connection branch resistance distribution will lead to uneven lateral solids suspension density distribution and circulation rates allocation. This effect is enhanced by growing superficial velocity