427 research outputs found
Prevalence study of yaws in the Democratic Republic of Congo using the lot quality assurance sampling method.
BACKGROUND: Until the 1970s the prevalence of non-venereal trepanomatosis, including yaws, was greatly reduced after worldwide mass treatment. In 2005, cases were again reported in the Democratic Republic of the Congo. We carried out a survey to estimate the village-level prevalence of yaws in the region of Equator in the north of the country in order to define appropriate strategies to effectively treat the affected population. METHODOLOGY/PRINCIPAL FINDINGS: We designed a community-based survey using the Lot Quality Assurance Sampling method to classify the prevalence of active yaws in 14 groups of villages (lots). The classification into high, moderate, or low yaws prevalence corresponded to World Health Organization prevalence thresholds for identifying appropriate operational treatment strategies. Active yaws cases were defined by suggestive clinical signs and positive rapid plasma reagin and Treponema pallidum hemagglutination serological tests. The overall prevalence in the study area was 4.7% (95% confidence interval: 3.4-6.0). Two of 14 lots had high prevalence (>10%), three moderate prevalence (5-10%) and nine low prevalence (<5%.). CONCLUSIONS/SIGNIFICANCE: Although yaws is no longer a World Health Organization priority disease, the presence of yaws in a region where it was supposed to be eradicated demonstrates the importance of continued surveillance and control efforts. Yaws should remain a public health priority in countries where previously it was known to be endemic. The integration of sensitive surveillance systems together with free access to effective treatment is recommended. As a consequence of our study results, more than 16,000 people received free treatment against yaws
Effect of channel block on the spiking activity of excitable membranes in a stochastic Hodgkin-Huxley model
The influence of intrinsic channel noise on the spontaneous spiking activity
of poisoned excitable membrane patches is studied by use of a stochastic
generalization of the Hodgkin-Huxley model. Internal noise stemming from the
stochastic dynamics of individual ion channels is known to affect the
collective properties of the whole ion channel cluster. For example, there
exists an optimal size of the membrane patch for which the internal noise alone
causes a regular spontaneous generation of action potentials. In addition to
varying the size of ion channel clusters, living organisms may adapt the
densities of ion channels in order to optimally regulate the spontaneous
spiking activity. The influence of channel block on the excitability of a
membrane patch of certain size is twofold: First, a variation of ion channel
densities primarily yields a change of the conductance level. Second, a
down-regulation of working ion channels always increases the channel noise.
While the former effect dominates in the case of sodium channel block resulting
in a reduced spiking activity, the latter enhances the generation of
spontaneous action potentials in the case of a tailored potassium channel
blocking. Moreover, by blocking some portion of either potassium or sodium ion
channels, it is possible to either increase or to decrease the regularity of
the spike train.Comment: 10 pages, 3 figures, published 200
New gas-filled mode of the large-acceptance spectrometer VAMOS
Spectromètre VAMOSA new gas-filled operation mode of the large-acceptance spectrometer VAMOS at GANIL is reported. A beam rejection factor greater than 1010 is obtained for the 40Ca+150Sm system at 196 MeV. The unprecedented transmission efficiency for the evaporation residues produced in this reaction is estimated to be around 80% for ®xn channels and above 95% for xnyp channels. A detailed study of the performance of the gasfilled VAMOS and future developments are discussed. This new operation mode opens avenues to explore the potential of fusion reactions in various kinematics
Modern Rutherford experiment: Tunneling of the most neutron-rich nucleus
Expérience GANIL/SPIRALA modern variation of the Rutherford experiment to probe the tunneling of exotic nuclear matter from the measurement of the residues formed in the bombardment of 197Au by extremely neutronrich 8He nuclei is presented. Using a novel off-beam technique the most precise and accurate measurements of fusion and neutron transfer involving re-accelerated unstable beams are reported. The results show unusual behavior of the tunneling of 8He compared to that for lighter helium isotopes, highlighting the role of the intrinsic structure of composite many-body quantum systems and pairing correlations
Low-lying level structure of Cu and its implications on the rp process
The low-lying energy levels of proton-rich Cu have been extracted
using in-beam -ray spectroscopy with the state-of-the-art -ray
tracking array GRETINA in conjunction with the S800 spectrograph at the
National Superconducting Cyclotron Laboratory at Michigan State University.
Excited states in Cu serve as resonances in the
Ni(p,)Cu reaction, which is a part of the rp-process in
type I x-ray bursts. To resolve existing ambiguities in the reaction Q-value, a
more localized IMME mass fit is used resulting in ~keV. We derive
the first experimentally-constrained thermonuclear reaction rate for
Ni(p,)Cu. We find that, with this new rate, the
rp-process may bypass the Ni waiting point via the Ni(p,)
reaction for typical x-ray burst conditions with a branching of up to
40. We also identify additional nuclear physics uncertainties that
need to be addressed before drawing final conclusions about the rp-process
reaction flow in the Ni region.Comment: 8 pages, accepted for Phys. Rev.
Identification of new transitions and mass assignments of levels in Pr
The previously reported levels assigned to 151,152,153Pr have recently been
called into question regarding their mass assignment. The above questioned
level assignments are clarified by measuring g-transitions tagged with A and Z
in an in-beam experiment in addition to the measurements from 252Cf spontaneous
fission (SF) and establish new spectroscopic information from to
in the Pr isotopic chain. The isotopic chain 143-153Pr has been studied from
the spontaneous fission of 252Cf by using Gammasphere and also from the
measurement of the prompt g-rays in coincidence with isotopically-identified
fission fragments using VAMOS++ and EXOGAM at GANIL. The latter were produced
using 238U beams on a 9Be target at energies around the Coulomb barrier. The
g-g-g-g data from 252Cf (SF) and those from the GANIL in-beam A- and Z-gated
spectra were combined to unambiguously assign the various transitions and
levels in 151,152,153Pr and other isotopes. New transitions and bands in
145,147,148,149,150Pr were identified by using g-g-g and g-g-g-g coincidences
and A and Z gated g-g spectra. The transitions and levels previously assigned
to 151,153Pr have been confirmed by the (A,Z) gated spectra. The transitions
previously assigned to 152Pr are now assigned to 151Pr on the basis of the
(A,Z) gated spectra. Two new bands with 20 new transitions in 152Pr and one new
band with 7 new transitions in 153Pr are identified from the g-g-g-g
coincidence spectra and the (A,Z) gated spectrum. In addition, new g-rays are
also reported in 143-146Pr. New levels of 145,147-153Pr have been established,
reliable mass assignments of the levels in 151,152,153Pr have been reported and
new transitions have been identified in 143-146Pr showing the new avenues that
are opened by combining the two experimental approaches.Comment: Accepted in Phys. Rev.
Isotopic Resolution of Fission Fragments from 238U+12C Transfer and Fusion Reactions
Expérience GANILInternational audienceRecent results from an experiment at GANIL, performed to investigate the main properties of fission-fragment yields and energy distributions in different fissioning nuclei as a function of the excitation energy, in a neutron-rich region of actinides, are presented. Transfer reactions in inverse kinematics between a 238U beam and a 12C target produced different actinides, within a range of excitation energy below 30 MeV. These fissioning nuclei are identified by detecting the target-like recoil, and their kinetic and excitation energy are determined from the reconstruction of the transfer reaction. The large-acceptance spectrometer VAMOS was used to identify the mass, atomic number and charge state of the fission fragments in flight. As a result, the characteristics of the fission-fragment isotopic distributions of a variety of neutron-rich actinides are observed for the first time over the complete range of fission fragments
Spectroscopy of Na: shell evolution toward the drip line
Excited states in Na have been studied using the -decay of
implanted Ne ions at GANIL/LISE as well as the in-beam -ray
spectroscopy at the NSCL/S800 facility. New states of positive
(J=3,4) and negative (J=1-5) parity are proposed. The
former arise from the coupling between 0d protons and a 0d
neutron, while the latter are due to couplings with 1p or 0f
neutrons. While the relative energies between the J=1-4 states are
well reproduced with the USDA interaction in the N=17 isotones, a progressive
shift in the ground state binding energy (by about 500 keV) is observed between
F and Al. This points to a possible change in the proton-neutron
0d-0d effective interaction when moving from stability to the
drip line. The presence of J=1-4 negative parity states around 1.5
MeV as well as of a candidate for a J=5 state around 2.5 MeV give
further support to the collapse of the N=20 gap and to the inversion between
the 0f and 1p levels below Z=12. These features are discussed
in the framework of Shell Model and EDF calculations, leading to predicted
negative parity states in the low energy spectra of the F and O
nuclei.Comment: Exp\'erience GANIL/LISE et NSCL/S80
Nuclear structure and reaction studies at SPIRAL
The SPIRAL facility at GANIL, operational since 2001, is described briefly.
The diverse physics program using the re-accelerated (1.2 to 25 MeV/u) beams
ranging from He to Kr and the instrumentation specially developed for their
exploitation are presented. Results of these studies, using both direct and
compound processes, addressing various questions related to the existence of
exotic states of nuclear matter, evolution of new "magic numbers", tunnelling
of exotic nuclei, neutron correlations, exotic pathways in astrophysical sites
and characterization of the continuum are discussed. The future prospects for
the facility and the path towards SPIRAL2, a next generation ISOL facility, are
also briefly presented.Comment: 48 pages, 27 figures. Accepted for publication in Journal of Physics
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